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The Journal of Physiology, EarlyView.Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor +4 more
wiley +1 more source
Promiscuity among the MRAPs. [PDF]
, 2017 The melanocortin 2 receptor accessory protein (MRAP) was originally discovered to be an essential co-receptor for the ACTH receptor/melanocortin 2 receptor, and it physically interacts with this receptor and is required for receptor trafficking and ...
Chan, LF, Clark, AJL
core +1 more source
Influence of MC1R Gene Variants on Coat Color of Indicine Cattle Breeds
Animal Genetics, Volume 57, Issue 3, June 2026.ABSTRACT Indicine cattle display a broad range of coat colors, representing a relevant and breed‐defining trait required for registration in breeder association. Among the genes involved in pigmentation, MC1R stands out for modulating the synthesis of melanin‐related proteins and remains poorly explored in indicine cattle breeds. Therefore, we aimed to
Silel V. S. A. Maciel +12 more
wiley +1 more source
Circadian adaptations to meal timing: Neuroendocrine mechanisms
Frontiers in Neuroscience, 2013 Circadian rhythms of behavior and physiology are generated by central and peripheral circadian oscillators entrained by periodic environmental or physiological stimuli.
Danica F Patton, Ralph E Mistlberger
doaj +1 more source
Melanocortin receptor accessory proteins in adrenal disease and obesity. [PDF]
, 2015 Melanocortin receptor accessory proteins (MRAPs) are regulators of the melanocortin receptor family. MRAP is an essential accessory factor for the functional expression of the MC2R/ACTH receptor.
Adrian J. Clark +88 more
core +2 more sources
Melanism as a potential thermal benefit in eastern fox squirrels (Sciurus niger) [PDF]
, 2019 Melanistic fox squirrels (Sciurus niger) have expanded westward and increased in frequency in the Omaha, Nebraska, and Council Bluffs, Iowa, metropolitan areas.
Ciurej, Amanda K. +3 more
core +2 more sources
Melanocortins and feeding behavior
Biomedicine & Pharmacotherapy, 2000 The melanocortin (ACTH/MSH) peptides exert a number of central effects. In the eighties, we described for the first time a role for melanocortins in the central control of appetite. We showed that the injection of ACTH-(1-24) into a brain lateral ventricle reduced food intake up to 76.6% in starved rats.
A V, Vergoni +2 more
openaire +2 more sources
Fifty Years Later, and We Still Don't Know About Badges of Status
Ecology and Evolution, Volume 16, Issue 5, May 2026.Overall, aggression and coloration are positively associated across species, but the generality of this relationship is low, the relationship depends on effect size origin, and the dataset requires further verification, which raises methodological concerns.
Alfredo Sánchez‐Tójar +1 more
wiley +1 more source
Anti-melanocortin-4 receptor autoantibodies in obesity [PDF]
, 2009 Background: The melanocortin-4 receptor (MC4R) is part of an important pathway regulating energy balance. Here we report the existence of autoantibodies (autoAbs) against the MC4R in sera of obese patients.
Bekel, A. +9 more
core +3 more sources
Melanocortins and opiate addiction
Life Sciences, 1997 Adrenocorticotropic hormone (ACTH) and alpha-melanocyte stimulating hormone (alpha-MSH) are centrally acting melanocortin peptides with numerous reported functions, including induction of excessive grooming and antipyresis, among others. Also reported is a role for melanocortins in aspects of opiate action.
J D, Alvaro, J B, Tatro, R S, Duman
openaire +2 more sources