Results 91 to 100 of about 57,827 (240)
Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction
Obesity Reviews, EarlyView.Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey +7 more
wiley +1 more source
The melanocortin system in the male reproductive axis
, 2014 Melanocortin receptors (MCS, MC1–MC5) are GPCRs, activated with different affinities by the melanocortin peptides (α-, β-, γ-MSH and ACTH). They are widely distributed throughout the body displaying a multitude of actions however their role in ...
Smith, C.L. +4 more
core +1 more source
POMC neurons control fertility through differential signaling of MC4R in kisspeptin neurons
eLifeInactivating mutations in the melanocortin 4 receptor (MC4R) gene cause monogenic obesity. Interestingly, female patients also display various degrees of reproductive disorders, in line with the subfertile phenotype of Mc4r KO female mice.
Rajae Talbi +11 more
doaj +1 more source
Obesity Reviews, EarlyView.ABSTRACT Despite all efforts, obesity remains a major health concern worldwide, with continuously increasing rates, affecting approx. 14% of the total world population, being as high as 43% in some countries. As obesity is related to numerous comorbidities, including type 2 diabetes, cardiovascular diseases, and some types of cancer, the consequences ...
Farhad Vahid +22 more
wiley +1 more source
Melanocortins and opiate addiction
Life Sciences, 1997 Adrenocorticotropic hormone (ACTH) and alpha-melanocyte stimulating hormone (alpha-MSH) are centrally acting melanocortin peptides with numerous reported functions, including induction of excessive grooming and antipyresis, among others. Also reported is a role for melanocortins in aspects of opiate action.
J D, Alvaro, J B, Tatro, R S, Duman
openaire +2 more sources
Rethinking Global Obesity Guidelines: Integrating Evidence, Equity and Precision (2014–2026)
Obesity Reviews, EarlyView.Challenges and evidence in obesity guidelines. ABSTRACT Obesity remains a global health crisis characterized by substantial heterogeneity in diagnosis, management, and policy implementation. Although numerous national and international clinical practice guidelines have been published over the past decade, their translation into evidence‐based and ...
Rosero‐Revelo Ricardo +13 more
wiley +1 more source
The Journal of Poultry Science, 2010 The agouti signaling protein (ASIP)/melanocortin signaling system regulates lipid metabolism in humans but not in mice. To examine whether the system is present in adipose tissues in chickens, we performed reverse transcription-polymerase chain reaction
Masafumi Yabuuchi +4 more
doaj +1 more source
Obesity Reviews, EarlyView.ABSTRACT Background Obesity's global rise has outpaced the effectiveness of “one‐size‐fits‐all” prevention and treatment strategies. The promise of precision medicine lies in addressing the etiological and biological diversity of obesity and transforming it into actionable endotypes.
Nadia Abu Samra +13 more
wiley +1 more source
, 2022 Melanocortin peptides containing a 3-(2-naphthyl)-d-alanine residue in position 7 (DNal(2′)7), reported as melanocortin-3 receptor (MC3R) subtype-specific agonists in two separate publications, were found to lack significant MC3R agonist activity.
Ren-Lei Ji (9241055) +21 more
core +1 more source
Zoologica Scripta, EarlyView.ABSTRACT The psammophilous colubrid genus Lytorhynchus is widely distributed in the deserts of the Saharo‐Sindian region and adjacent areas. The taxonomy of the genus and the number of recognised species have remained unstable since the last taxonomic revision in 1970, with differing views on the taxonomic status of L. gaddi and L. kennedyi.
Lukáš Pola +10 more
wiley +1 more source