Effect of NDP-α-MSH on PPAR-γ and -β expression and anti-inflammatory cytokine release in rat astrocytes and microglia. [PDF]
PLoS ONE, 2013 Brain inflammation plays a central role in numerous brain pathologies. Microglia and astrocytes are the main effector cells that become activated when an inflammatory process takes place within the central nervous system. α-melanocyte-stimulating hormone
Lila Carniglia +3 more
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Ligands for Melanocortin Receptors: Beyond Melanocyte-Stimulating Hormones and Adrenocorticotropin [PDF]
Biomolecules, 2022 The discovery of melanocortins in 1916 has resulted in more than 100 years of research focused on these peptides. Extensive studies have elucidated well-established functions of melanocortins mediated by cell surface receptors, including MSHR (melanocyte-
Xiao-Chen Yuan, Ya-Xiong Tao
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Melanocortins, Melanocortin Receptors and Multiple Sclerosis
Brain Sciences, 2017 The melanocortins and their receptors have been extensively investigated for their roles in the hypothalamo-pituitary-adrenal axis, but to a lesser extent in immune cells and in the nervous system outside the hypothalamic axis.
Joyce A Benjamins
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Developments and new vistas in the field of melanocortins
Biomolecular Concepts, 2015 Melanocortins play a fundamental role in several basic functions of the organism (sexual activity, feeding, inflammation and immune responses, pain sensitivity, response to stressful situations, motivation, attention, learning, and memory).
Giorgio Noera
exaly +2 more sources
Loss-of-function mutations in the melanocortin-2-receptor (mc2r) lead to skin hyperpigmentation in teleost fish [PDF]
Scientific ReportsMelanocortins regulate pigmentation via melanocortin receptors (MCRs), which are highly conserved across vertebrates. Unlike other MCRs, the melanocortin 2 receptor (MC2R) is exclusively activated by ACTH; however, its role in pigmentation remains ...
Elisa Barreiro-Docío +9 more
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Alpha-Melanocyte-Stimulating Hormone Maintains Retinal Homeostasis after Ischemia/Reperfusion [PDF]
BiomoleculesAugmenting the natural melanocortin pathway in mouse eyes with uveitis or diabetes protects the retinas from degeneration. The retinal cells are protected from oxidative and apoptotic signals of death.
Tat Fong Ng +10 more
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Evolutionary Plasticity in Insular Lizard, Adapting over Reproduction, Metabolism, and Color Variation [PDF]
Biology, 2023 The Italian wall lizard (Podarcis siculus) living on islets exhibits a melanic skin coloration and a suite of adaptive traits lacking in nearby mainland populations.
Domenico Fulgione +5 more
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Editorial: Melanocortins and melanocortin receptors in the regulation of inflammation: mechanisms and novel therapeutic strategies [PDF]
Frontiers in Immunology, 2023 Petteri Rinne +3 more
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The genetics of obesity: A narrative review [PDF]
Precision and Future Medicine, 2022 Monogenic obesity is a rare, early-onset, and severe form of obesity that has a Mendelian inheritance pattern, high penetrance, and large genetic effect. In contrast, common polygenic obesity is more prevalent and has pattern of heritability derived from
Young Bae Sohn
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Anxiety and Depression: What Do We Know of Neuropeptides?
Behavioral Sciences, 2022 In modern society, there has been a rising trend of depression and anxiety. This trend heavily impacts the population’s mental health and thus contributes significantly to morbidity and, in the worst case, to suicides.
Ida Kupcova +3 more
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