Results 1 to 10 of about 1,543 (156)
Cardiovascular effects of melanocortins [PDF]
European Journal of Pharmacology, 2011 Melanocortins (MSH's) are three structurally related peptides derived from proopiomelanocortin. They regulate several physiologic functions including energy metabolism, appetite, and inflammation. Recent work in rodents has also identified important effects of MSH's, particularly γ-MSH, on sodium metabolism and blood pressure regulation.
Michael H, Humphreys +2 more
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The Role of Melanocortin Plasticity in Pain-Related Outcomes After Alcohol Exposure
Frontiers in Psychiatry, 2021 The global COVID-19 pandemic has shone a light on the rates and dangers of alcohol misuse in adults and adolescents in the US and globally. Alcohol exposure during adolescence causes persistent molecular, cellular, and behavioral changes that increase ...
Nathan Sharfman +4 more
doaj +1 more source
Melanocortin System in Kidney Homeostasis and Disease: Novel Therapeutic Opportunities
Frontiers in Physiology, 2021 Melanocortin peptides, melanocortin receptors, melanocortin receptor accessory proteins, and endogenous antagonists of melanocortin receptors are the key components constituting the melanocortin hormone system, one of the most complex and important ...
Mingyang Chang +4 more
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Melanocortin Peptide Therapy for the Treatment of Arthritic Pathologies
The Scientific World Journal, 2009 Arthritic pathologies are a major cause of morbidity within the western world, with rheumatoid arthritis affecting approximately 1% of adults. This review highlights the therapeutic potential of naturally occurring hormones and their peptides, in both ...
S. J. Getting +7 more
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α-MSH Stimulates Glucose Uptake in Mouse Muscle and Phosphorylates Rab-GTPase-Activating Protein TBC1D1 Independently of AMPK. [PDF]
PLoS ONE, 2016 The melanocortin system includes five G-protein coupled receptors (family A) defined as MC1R-MC5R, which are stimulated by endogenous agonists derived from proopiomelanocortin (POMC).
Cathrine Laustrup Møller +9 more
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Aquaculture Reports, 2022 The skin color differentiation and variation are the main problems limiting the development of red tilapia commercial culture. The specific function and regulation mechanism of mc1r gene in fish pigmentation are still poorly understood. In this study, we
Lan-mei Wang +6 more
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Reproductive Biology and Endocrinology, 2008 Background Neuropeptide Y (NPY), agouti related peptide (AgRP), cocaine and amphetamine-regulated transcript (CART) and melanocortins, the products of the proopiomelanocortin (POMC), are hypothalamic peptides involved in feeding regulation and energy ...
Cepeda Libia A +8 more
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Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5. [PDF]
PLoS ONE, 2015 In this study, we showed that adrenocorticotropic hormone (ACTH) promoted erythroblast differentiation and increased the enucleation ratio of erythroblasts.
Eriko Simamura +9 more
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Biology, 2023 The Italian wall lizard (Podarcis siculus) living on islets exhibits a melanic skin coloration and a suite of adaptive traits lacking in nearby mainland populations.
Domenico Fulgione +5 more
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ACTH Prevents Deficits in Fear Extinction Associated with Early Life Seizures
Frontiers in Neurology, 2016 Early life seizures are often associated with cognitive and psychiatric comorbidities that are detrimental to quality of life. In a rat model of early life seizures (ELS), we explored long-term cognitive outcomes in adult rats. Using ACTH, an endogeneous
Andrew T Massey +6 more
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