The Multifaceted Melanocortin Receptors
Endocrinology, 2022 AbstractThe 5 known melanocortin receptors (MCs) have established physiological roles. With the exception of MC2, these receptors can behave unpredictably, and since they are more widely expressed than their established roles would suggest, it is likely that they have other poorly characterized functions.
Linda Laiho, Joanne Fiona Murray
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Anxiety and Depression: What Do We Know of Neuropeptides?
Behavioral Sciences, 2022 In modern society, there has been a rising trend of depression and anxiety. This trend heavily impacts the population’s mental health and thus contributes significantly to morbidity and, in the worst case, to suicides.
Ida Kupcova +3 more
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The effect of six weeks high intensity interval training on protein expression of Melanocortin 1 Receptor of monocytes and plasma levels of Alpha melanocyte stimulating hormone in overweight men [PDF]
فیزیولوژی ورزش و فعالیت بدنی, 2012 Objectives: The purpose of this study is to investigate the effect of six weeks high intensity interval training (HIT)on protein expression of Melanocortin 1 Receptor (MC1R) of monocytes and plasma levels of melanocytestimulating hormone alpha (∝-MSH) in
سید محسن آوندی +3 more
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Ligands for Melanocortin Receptors: Beyond Melanocyte-Stimulating Hormones and Adrenocorticotropin
Biomolecules, 2022 The discovery of melanocortins in 1916 has resulted in more than 100 years of research focused on these peptides. Extensive studies have elucidated well-established functions of melanocortins mediated by cell surface receptors, including MSHR (melanocyte-
Xiao-Chen Yuan, Ya-Xiong Tao
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MOLECULAR EVOLUTION OF GPCRS: Melanocortin/melanocortin receptors [PDF]
Journal of Molecular Endocrinology, 2014 The melanocortin receptors (MCRs) are a family of G protein-coupled receptors that are activated by melanocortin ligands derived from the proprotein, proopiomelanocortin (POMC). During the radiation of the gnathostomes, the five receptors have become functionally segregated (i.e.
Robert M, Dores +5 more
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Antifibrotic and Anti-Inflammatory Actions of α-Melanocytic Hormone: New Roles for an Old Player
Pharmaceuticals, 2021 The melanocortin system encompasses melanocortin peptides, five receptors, and two endogenous antagonists. Besides pigmentary effects generated by α-Melanocytic Hormone (α-MSH), new physiologic roles in sexual activity, exocrine secretion, energy ...
Roshan Dinparastisaleh, Mehdi Mirsaeidi
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Novel Emerging Therapies for Erectile Dysfunction
The World Journal of Men's Health, 2021 Currently, several treatments exist for the improvement of erectile dysfunction (ED). These include medical therapies such as phosphodiesterase type 5 inhibitors (PDE5-Is), invasive methods such as intracavernosal injection therapy of vaso-active ...
Soyeun Kim +4 more
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Effect of NDP-α-MSH on PPAR-γ and -β expression and anti-inflammatory cytokine release in rat astrocytes and microglia. [PDF]
PLoS ONE, 2013 Brain inflammation plays a central role in numerous brain pathologies. Microglia and astrocytes are the main effector cells that become activated when an inflammatory process takes place within the central nervous system. α-melanocyte-stimulating hormone
Lila Carniglia +3 more
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Role of the Melanocortin System in Gonadal Steroidogenesis of Zebrafish
Animals, 2022 In teleost, as in other vertebrates, stress affects reproduction. A key component of the stress response is the pituitary secretion of the adrenocorticotropic hormone (ACTH), which binds to the melanocortin 2 receptor (MC2R) in the adrenal glands and ...
Sandra Navarro +6 more
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Melanocortin receptors as novel effectors of macrophage responses in inflammation
Frontiers in Immunology, 2011 Macrophages have crucial functions in initiating the inflammatory reaction in a strict temporal and spatial manner to provide a ‘clear-up’ response required for resolution.
Hetal B Patel +3 more
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