Results 41 to 50 of about 3,506 (222)

Signal Transduction and Pathogenic Modifications at the Melanocortin-4 Receptor: A Structural Perspective [PDF]

, 2019
The melanocortin-4 receptor (MC4R) can be endogenously activated by binding of melanocyte-stimulating hormones (MSH), which mediates anorexigenic effects. In contrast, the agouti-related peptide (AgRP) acts as an endogenous inverse agonist and suppresses
Biebermann, Heike, Cerdá-Reverter, José Miguel, Heyder, Nicolas, Kleinau, Gunnar, Krude, Heiko, Kwiatkowski, Dennis, Kühnen, Peter, Scheerer, Patrick, Soletto, Lucia, Speck, David, Szczepek, Michal   +10 more
core   +1 more source

Role of the Melanocortin System in the Central Regulation of Cardiovascular Functions

Frontiers in Physiology, 2021
Increasing evidence indicates that the melanocortin system is not only a central player in energy homeostasis, food intake and glucose level regulation, but also in the modulation of cardiovascular functions, such as blood pressure and heart rate.
Francesca Copperi, Jung Dae Kim, Sabrina Diano, Sabrina Diano, Sabrina Diano   +4 more
doaj   +1 more source

Effect of an ACTH(4-9) analogue on cisplatin neuropathy of longstanding duration: A phase II study [PDF]

, 1995
The efficacy of Org 2766, an ACTH(4–9) analogue, on the recovery of cisplatin neuropathy of longstanding duration was investigated in a phase II study.
Bent, M.J. (Martin) van den, Burg, M.E.L. (Maria) van der, Hilkens, P.H.E., Moll, J.W.B. (Wibe), Putten, W.L.J. (Wim) van, Vecht, C.J. (Charles)   +5 more
core   +1 more source

Increased circulating ANG II and TNF-α represents important risk factors in obese Saudi adults with hypertension irrespective of diabetic status and BMI [PDF]

, 2012
Central adiposity is a significant determinant of obesity-related hypertension risk, which may arise due to the pathogenic inflammatory nature of the abdominal fat depot.
A Berrington de Gonzalez, A Harte, A Taube, AG Bertoni, Aimin Xu, Alison L. Harte, Amany O. Mohamed, AV Chobanian, B Chamarthi, BL Goodwin, BM Celoria, BM Cheung, C Asferg, C Asferg, C Savoia, D Gurantz, D Kalra, D Ma, ES Androulakis, F Galletti, F Galletti, G Mancia, H Itani, H Zhang, Hossam M. Draz, J Feber, J Liu, JD Fowler, JE Hall, JM do Carmo, JV Patel, K Ohashi, KF Adams, Khalid M. Alkharfy, L Alhyas, LE Bautista, Lotfi S. Bindahman, M Adamczak, M Carlyle, M Hernandez-Presa, M Pruijm, M Tohidi, M Vlasova, MA Al-Homrany, Majed S. Alokail, MY Baden, N Al-Daghri, Nasser M. Al-Daghri, NM Al-Daghri, NS Kalupahana, Omar S. Al-Attas, Philip G. McTernan, R Fogari, R Summer, RT Sabo, S Sriramula, S Yasue, Sobhy Yakout, T Wago, TA Kotchen, Tahia H. Saleem, X Gao, Y Deng, Y Takeshita   +63 more
core   +2 more sources

Differential effects of melanocortin peptides on neural melanocortin receptors.

Molecular Pharmacology, 1994
Melanocortins (MCs) have various physiological actions on the brain. The recent cloning of neural MC receptors opened new avenues to study the effects of these neuropeptides on the nervous system. Here we investigated the structure-activity relationships (SARs) of peptides derived from adrenocorticotropic hormone (ACTH) with cloned MC3 and MC4 ...
Gispen, W.H., Adan, R.A.H., Cone, R.D., Burbach, J.P.H.   +3 more
openaire   +4 more sources

The melanocortin receptors and their accessory proteins. [PDF]

, 2013
The five melanocortin receptors (MCRs) named MC1R-MC5R have diverse physiological roles encompassing pigmentation, steroidogenesis, energy homeostasis and feeding behavior as well as exocrine function.
Chan, LF, Clark, AJ, Gorrigan, RJ, Ramachandrappa, S   +3 more
core   +2 more sources

Genetic Diversity, Adaptation, Wild Introgression, and Coat Color Mutation of Golden Yak

Animal Research and One Health, EarlyView.
Genetic diversity, adaptation, wild introgression, and coat color mutation of golden yak from two populations on the Qinghai‐Xizang Plateau. ABSTRACT The golden yak lives on the Qinghai‐Xizang Plateau with a golden coat and adapts to high altitudes and strong ultraviolet environment. The golden coat is a prominent phenotype in many domesticated species,
Huixuan Yan, Jialei Chen, Chuzhao Lei, Fengwei Zhang, Shunzhong He, Weiru Song, Hongyan Ma, Shuling Li, Guomei Li, Laba Yongcuo, Jianlin Han, Johannes A. Lenstra, Qiang Zhang, Rende Song, Basang Wangdui, Ningbo Chen   +15 more
wiley   +1 more source

Cardiovascular effects of melanocortins [PDF]

European Journal of Pharmacology, 2011
Melanocortins (MSH's) are three structurally related peptides derived from proopiomelanocortin. They regulate several physiologic functions including energy metabolism, appetite, and inflammation. Recent work in rodents has also identified important effects of MSH's, particularly γ-MSH, on sodium metabolism and blood pressure regulation.
Michael H, Humphreys, Xi-Ping, Ni, David, Pearce   +2 more
openaire   +2 more sources

Tissue Sodium Content and Arterial Hypertension in Obese Adolescents [PDF]

, 2019
Early-onset obesity is known to culminate in type 2 diabetes, arterial hypertension and subsequent cardiovascular disease. The role of sodium (Na+) homeostasis in this process is incompletely understood, yet correlations between Na+ accumulation and ...
Berger, Felix, Birukov, Anna, Ghorbani, Niky, Hennemuth, Anja, Jones, Alexander, Kelm, Marcus, Kuehne, Titus, Kühnen, Peter, Linz, Peter, Markó, Lajos, Müller, Dominik N., Roth, Sophie, Wiegand, Susanna   +12 more
core   +3 more sources

Genomic Insights Into Risperidone Treatment Outcomes in Children and Adolescents: Experience From a Psychiatric Hospital Serving Rural Youth

Clinical Pharmacology &Therapeutics, EarlyView.
Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples, Shayna R. Killam, Karen E. Brown, Rachel Dalton, Elizabeth Sather, Qiang Chen, Joshua Loveland, Corbin Schwanke, Abdallah F. Elias, Kristin L. Bigos, Erica L. Woodahl   +10 more
wiley   +1 more source