Results 31 to 40 of about 1,543 (156)

Central melanocortins regulate the motivation for sucrose reward. [PDF]

PLoS ONE, 2015
The role of the melanocortin (MC) system in feeding behavior is well established. Food intake is potently suppressed by central infusion of the MC 3/4 receptor agonist α-melanocyte stimulating hormone (α-MSH), whereas the MC 3/4 receptor inverse-agonist ...
Rahul Pandit, Esther M van der Zwaal, Mieneke C M Luijendijk, Maike A D Brans, Andrea J van Rozen, Ralph J A Oude Ophuis, Louk J M J Vanderschuren, Roger A H Adan, Susanne E la Fleur   +8 more
doaj   +1 more source

Differential effects of melanocortin peptides on neural melanocortin receptors.

Molecular Pharmacology, 1994
Melanocortins (MCs) have various physiological actions on the brain. The recent cloning of neural MC receptors opened new avenues to study the effects of these neuropeptides on the nervous system. Here we investigated the structure-activity relationships (SARs) of peptides derived from adrenocorticotropic hormone (ACTH) with cloned MC3 and MC4 ...
Gispen, W.H., Adan, R.A.H., Cone, R.D., Burbach, J.P.H.   +3 more
openaire   +4 more sources

Novel therapeutics in rare genetic obesities: A narrative review

Pharmacological Research, 2023
The better understanding of the molecular causes of rare genetic obesities and its associated phenotype involving the hypothalamus allows today to consider innovative therapeutics focused on hunger control.
Beatrice Dubern, Nathan Faccioli, Christine Poitou, Karine Clément   +3 more
doaj   +1 more source

The Influence of α-, β-, and γ-Melanocyte Stimulating Hormone on Acetaminophen Induced Liver Lesions in Male CBA Mice

Molecules, 2010
Research over the past decade has indicated that melanocortin peptides are potent inhibitors of inflammation and a promising source of new anti-inflammatory and cytoprotective therapies.
Vladimir Blagaić, Karlo Houra, Petra Turčić, Nikola Štambuk, Paško Konjevoda, Alenka Boban-Blagaić, Tomislav Kelava, Marina Kos, Gorana Aralica, Filip Čulo   +9 more
doaj   +1 more source

Intrinsic Control and Environmental Factors in Food Consumption Related to Obesity

Southeastern European Medical Journal, 2017
Obesity results from a complex interactions of genetic, hormonal, physiological, anatomical, psychological, behavioral and environmental factors causing an imbalance between energy intake and energy expenditure. According to the World Health Organization
Ivana Jukić, Aleksandar Kibel , Dijana Kibel , Ines Drenjančević   +3 more
doaj   +1 more source

Structure–Activity Relationships of the Tetrapeptide Ac-His-Arg-(pI)DPhe-Tic-NH₂ at the Mouse Melanocortin Receptors: Modification at the (pI)DPhe Position Leads to mMC3R Versus mMC4R Selective Ligands

Molecules, 2019
The five melanocortin receptors (MC1R–MC5R) are involved in numerous biological pathways, including steroidogenesis, pigmentation, and food intake.
Katherine N. Schlasner, Mark D. Ericson, Skye R. Doering, Katie T. Freeman, Mary Weinrich, Carrie Haskell-Luevano   +5 more
doaj   +1 more source

The Local Neuropeptide System of Keratinocytes

Biomedicines, 2021
Neuropeptides have been known for over 50 years as chemical signals in the brain. However, it is now well established that the synthesis of this class of peptides is not restricted to neurons. For example, human skin not only expresses several functional
Nicola Cirillo
doaj   +1 more source

The transcriptional regulator PRDM12 is critical for Pomc expression in the mouse hypothalamus and controlling food intake, adiposity, and body weight

Molecular Metabolism, 2020
Objective: Regulation of food intake and energy balance depends on a group of hypothalamic neurons that release anorexigenic melanocortins encoded by the Pomc gene.
Clara E. Hael, Daniela Rojo, Daniela P. Orquera, Malcolm J. Low, Marcelo Rubinstein   +4 more
doaj   +1 more source

Role of the Melanocortin System in the Central Regulation of Cardiovascular Functions

Frontiers in Physiology, 2021
Increasing evidence indicates that the melanocortin system is not only a central player in energy homeostasis, food intake and glucose level regulation, but also in the modulation of cardiovascular functions, such as blood pressure and heart rate.
Francesca Copperi, Jung Dae Kim, Sabrina Diano, Sabrina Diano, Sabrina Diano   +4 more
doaj   +1 more source

Fish melanocortin system [PDF]

European Journal of Pharmacology, 2011
Melanocortin signalling is mediated by binding to a family of G protein-coupled receptors that positively couple to adenylyl cyclase. Tetrapod species have five melanocortin (MC(1)-MC(5)) receptors. The number of receptors varies in fish, zebrafish, for example, having six melanocortin receptors, with two copies of the melanocortin MC(5) receptor ...
Cerdá-Reverter, José Miguel, Agulleiro Gozalbo, Maria Josep, Guillot, Raúl, Sánchez Martínez, Elisa, Ceinos, Rosa M., Rotllant, Josep   +5 more
openaire   +3 more sources