Results 31 to 40 of about 3,506 (222)

The role of hypothalamus-pituitary-adrenal (HPA)-like axis in inflammatory pilosebaceous disorders [PDF]

, 2020
Skin is the largest peripheral endocrine organ and functions as a hormone target and endocrine gland. A cutaneous hypothalamus-pituitary-adrenal (HPA)-like axis enables the skin to respond to stress and regulates its steroidogenic activity.
Clark, Ashley K, Saric-Bosanac, Suzana, Shi, Vivian Y, Sivamani, Raja K   +3 more
core  

Melanocortin Pathways: Suppressed and Stimulated Melanocortin-4 Receptor (MC4R)

Physiological Research, 2020
Leptin-melanocortin pathway plays an essential role in the body weight regulation. Enhanced melanocortin signaling in the hypothalamus results in both decreased food intake and increased energy expenditure. The discovery of monogenic obesities with dysfunction of melanocortin-4 receptor (MC4R) greatly contributed to understanding of energy balance ...
V, Hainer, I, Aldhoon Hainerová, M, Kunešová, R, Taxová Braunerová, H, Zamrazilová, B, Bendlová   +5 more
openaire   +2 more sources

The Local Neuropeptide System of Keratinocytes

Biomedicines, 2021
Neuropeptides have been known for over 50 years as chemical signals in the brain. However, it is now well established that the synthesis of this class of peptides is not restricted to neurons. For example, human skin not only expresses several functional
Nicola Cirillo
doaj   +1 more source

Melanocortin peptides protect chondrocytes from mechanically induced cartilage injury [PDF]

, 2014
Introduction Mechanical injury can greatly influence articular cartilage, propagating inflammation, cell injury and death – risk factors for the development of osteoarthritis.
Alexander, Baker, Bazzani, Bazzani, Berenbaum, Blanco, Bohm, Borrelli, Brown, Buckley, Buckley, Buckwalter, Bush, Carames, Carman, Catania, Ceriani, Daniel, Del Carlo, D’Lima, D’Lima, Elsaid, Ferguson, Fernandes, Ferretti, G. Paul Curley, Gelber, Getting, Getting, Getting, Getting, Getting, Getting, Giuliani, Glyn, Gosset, Grassel, Grieco, Guarini, Guarini, Hashimoto, Heraud, Holloway, Hruby, Huang, Ian C. Locke, Intekhab-Alam, Kaneva, Kannengiesser, Kerrigan, Kim, Kobayashi, Kurz, Lam, Land, Lawrence, Lawrence, Lee, Lefkowitz, Levin, Lohmander, Lohmander, Lu, Magdalena K. Kaneva, Majewski, Mark J.P. Kerrigan, Martel-Pelletier, Mioni, Montero-Melendez, Muceniece, Muller, Murphy, Oppenheimer, Ottani, Paolo Grieco, Patel, Phillips, Quinn, Raap, Rai, Rajora, Roos, Scanzello, Shlopov, Spaccapelo, Spaccapelo, Stephen J. Getting, Stockwell, Surendran, Szczodry, Westin, Wilder, Yoon, Zhou   +93 more
core   +1 more source

Both MC1 and MC3 Receptors Provide Protection From Cerebral Ischemia-Reperfusion-Induced Neutrophil Recruitment. [PDF]

, 2015
Objective Neutrophil recruitment is a key process in the pathogenesis of stroke, and may provide a valuable therapeutic target. Targeting the melanocortin receptors (MC) has previously shown to inhibit leukocyte recruitment in peripheral inflammation ...
Cooper, D., Cooper, D., Cvek, U., Cvek, U., Durrenberger, P.F., Durrenberger, P.F., Gavins, F.N., Gavins, F.N., Getting, S.J., Getting, S.J., Holloway, P.M., Holloway, P.M., Orr, A.W., Orr, A.W., Perretti, M., Perretti, M., Trutschl, M., Trutschl, M.   +17 more
core   +1 more source

The Influence of α-, β-, and γ-Melanocyte Stimulating Hormone on Acetaminophen Induced Liver Lesions in Male CBA Mice

Molecules, 2010
Research over the past decade has indicated that melanocortin peptides are potent inhibitors of inflammation and a promising source of new anti-inflammatory and cytoprotective therapies.
Vladimir Blagaić, Karlo Houra, Petra Turčić, Nikola Štambuk, Paško Konjevoda, Alenka Boban-Blagaić, Tomislav Kelava, Marina Kos, Gorana Aralica, Filip Čulo   +9 more
doaj   +1 more source

The transcriptional regulator PRDM12 is critical for Pomc expression in the mouse hypothalamus and controlling food intake, adiposity, and body weight

Molecular Metabolism, 2020
Objective: Regulation of food intake and energy balance depends on a group of hypothalamic neurons that release anorexigenic melanocortins encoded by the Pomc gene.
Clara E. Hael, Daniela Rojo, Daniela P. Orquera, Malcolm J. Low, Marcelo Rubinstein   +4 more
doaj   +1 more source

Intrinsic Control and Environmental Factors in Food Consumption Related to Obesity

Southeastern European Medical Journal, 2017
Obesity results from a complex interactions of genetic, hormonal, physiological, anatomical, psychological, behavioral and environmental factors causing an imbalance between energy intake and energy expenditure. According to the World Health Organization
Ivana Jukić, Aleksandar Kibel , Dijana Kibel , Ines Drenjančević   +3 more
doaj   +1 more source

Pathophysiology of melanocortin receptors and their accessory proteins. [PDF]

, 2018
The melanocortin receptors (MCRs) and their accessory proteins (MRAPs) are involved in regulation of a diverse range of endocrine pathways. Genetic variants of these components result in phenotypic variation and disease. The MC1R is expressed in skin and
A.J.L. Clark, Anderson, Asai, Balthasar, Begriche, Benjannet, Bishop, Box, Buggy, Bultman, Butler, Butler, Böhm, Chakraborty, Chaly, Chan, Chan, Chan, Chen, Chen, Chen, Cheung, Chida, Chung, Chung, Clark, Clark, Clark, Clark, Coll, Collet, Cone, Cone, Cooray, Cooray, Cooray, Cui, D'Orazio, do Carmo, Elias, Enriori, Farooqi, Feng, Flier, Friedman, Gee, Ghamari-Langroudi, Girardet, Gonzalez-Rey, Gorrigan, Greenfield, Huszar, Jarrett, Kievit, Kim, L.F. Chan, Landi, Lee, Lee, Lembertas, Lim, Lovett, Lowry, Lu, Manceau, Markison, Marks, Marsh, Martinelli, Metherell, Metherell, Miller, Mirshahi, Morgan, Morgan, Morgan, Mountjoy, Mountjoy, Ni, Nimura, Novoselova, O'Rahilly, Ogawa, Ollmann, Padilla, Palmer, Pasquali, Pelleymounter, Raadsheer, Rached, Raimondi, Robbins, Robles-Espinoza, Rodrigues, Roselli-Rehfuss, Rouault, Roy, Schauer, Scott, Sebag, Sebag, Shen, Shenker, Simamura, Smith, Smith, Sohn, Srisai, Swords, T.V. Novoselova, Tao, Turan, Ulrich-Lai, Vaisse, Valverde, Vinson, Webb, Webb, Weber, Williams, Xu, Xu, Yang, Yeo, Young, Zhang, Zhang   +126 more
core   +2 more sources

Structure–Activity Relationships of the Tetrapeptide Ac-His-Arg-(pI)DPhe-Tic-NH₂ at the Mouse Melanocortin Receptors: Modification at the (pI)DPhe Position Leads to mMC3R Versus mMC4R Selective Ligands

Molecules, 2019
The five melanocortin receptors (MC1R–MC5R) are involved in numerous biological pathways, including steroidogenesis, pigmentation, and food intake.
Katherine N. Schlasner, Mark D. Ericson, Skye R. Doering, Katie T. Freeman, Mary Weinrich, Carrie Haskell-Luevano   +5 more
doaj   +1 more source