Results 71 to 80 of about 57,827 (240)

The Central Melanocortin System and Human Obesity

, 2020
The prevalence of obesity and the associated comorbidities highlight the importance of understanding the regulation of energy homeostasis. The central melanocortin system plays a critical role in controlling body weight balance.
Xu, Yong, Yang, Yongjie
core   +1 more source

Cutaneous Pigmentary Changes During Setmelanotide Therapy: Dermoscopic and Confocal Findings in Two Patients

JEADV Clinical Practice, EarlyView.
ABSTRACT Setmelanotide is a melanocortin‐4 receptor agonist approved for the treatment of rare forms of genetic obesity. Through off‐target activation of the melanocortin‐1 receptor, it may induce cutaneous pigmentation changes; however, data regarding its effects on melanocytic nevi remain limited.
Martina Cavicchi, Claudia Lasagni, Silvana Ciardo, Francesca Giusti, Albino Eccher, Caterina Longo   +5 more
wiley   +1 more source

Gut microbiota as a novel therapeutic target for eating disorders and obesity

British Journal of Pharmacology, EarlyView.
The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė, Victor Mathis, Emmanuel Darcq, Aurelijus Burokas, Elena Martín‐García, Rafael Maldonado   +5 more
wiley   +1 more source

Gene polymorphisms and their effects in the melanocortin system

, 2005
In addition to its role in human pigmentation, components of the melanocortin system regulate appetite, energy homeostasis and hormone production. Recent studies have suggested possible roles of this system in immunity, transmission of pain signals, and ...
van Daal, Angela M., Levi Carroll, Carroll, Levi J., Angela van Daal, Voisey, Joanne, Joanne Voisey   +5 more
core   +1 more source

The Importance of Melanocortin Receptors and Their Agonists in Pulmonary Disease

Frontiers in Medicine, 2019
Melanocortin agonists are ancient neuropeptides that have steroidogenesis and anti-inflammatory properties. They activate melanocortin receptors (MCR), a family of five seven-transmembrane G-protein coupled receptors. MC1R and MC3R are mainly involved in
Anna Elizabeth Moscowitz, Huda Asif, Laurence Baily Lindenmaier, Andrew Calzadilla, Chongxu Zhang, Mehdi Mirsaeidi, Mehdi Mirsaeidi   +6 more
doaj   +1 more source

Therapeutic access points: The roles of circumventricular organs in drug delivery and metabolic regulation

British Journal of Pharmacology, EarlyView.
The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral, Nicholas Monaco, Daniel I. Brierley, Monica Imbernon   +3 more
wiley   +1 more source

Eruptive Acral Melanocytic Lesions Associated With Capecitabine

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Eruptive nevi and lentigines have been reported to occur in the setting of immunosuppression, which may be medication‐induced. The associated histopathologic findings have not been well described in the literature. Herein, we report the case of a woman in her 60s who had been receiving chemotherapy treatment with capecitabine, a prodrug of 5 ...
Madison Smith, Annie Jin, Jonathan A. Miles, Rosalie Elenitsas, Danielle M. DeHoratius, Emily Y. Chu   +5 more
wiley   +1 more source

Semaglutide for Treating Paediatric Craniopharyngioma‐Related Obesity: A Multicentre Case Series

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Obesity is a complication of childhood craniopharyngioma that remains difficult to treat. We investigated whether semaglutide was associated with a decrease in BMI among adolescents with craniopharyngioma‐related obesity. Material and Methods This multicentre retrospective study included 20 patients < 18 years old with craniopharyngioma ...
Joanne Dornberger, Pascal Barat, Karine Aouchiche, Kevin Perge, Carine Villanueva, Sarah Castets, Natacha Bouhours‐Nouet, Aurelie Donzeau, Lucie Levaillant, Cecile Teinturier, Rachel Reynaud, Ahlam Azar‐Kolakez, Laetitia Martinerie, Dulanjalee Kariyawasam, Regis Coutant   +14 more
wiley   +1 more source

Circadian adaptations to meal timing: Neuroendocrine mechanisms

Frontiers in Neuroscience, 2013
Circadian rhythms of behavior and physiology are generated by central and peripheral circadian oscillators entrained by periodic environmental or physiological stimuli.
Danica F Patton, Ralph E Mistlberger
doaj   +1 more source

Convergent mutations underpin the repeated evolution of brown plumage in seabirds

Ibis, EarlyView.
Recent genetic data have provided crucial insights into the evolution of animal colour phenotypes, with the melanocortin‐1 receptor (MC1R) frequently implicated in dramatic colour shifts. However, the extent to which similar phenotypes are underpinned by convergent mutations at this locus remains unclear.
Shanshan Shen, Graham A. McCulloch, Tania M. King, Nicolas J. Rawlence, Martyn Kennedy, Jonathan M. Waters   +5 more
wiley   +1 more source