Results 31 to 40 of about 57,827 (240)
Localisation of the melanocortin-2-receptor and its accessory proteins in the developing and adult adrenal gland [PDF]
, 2011 The melanocortin-2-receptor (MC2R)/MC2R accessory protein (MRAP) complex is critical to the production of glucocorticoids from the adrenal cortex. Inactivating mutations in either MC2R or MRAP result in the clinical condition familial glucocorticoid ...
Leonardo Guasti +9 more
core +1 more source
Frontiers in Endocrinology, 2013 Proopiomelanocortin (POMC) is the precursor of several peptide hormones generated in the pituitary gland. After biosynthesis, POMC undergoes several posttranslational modifications, including proteolytic cleavage, acetylation, amidation, phosphorylation,
Akiyoshi eTakahashi, Kanta eMizusawa
doaj +1 more source
Angewandte Chemie, EarlyView.Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma +5 more
wiley +2 more sources
Bioluminescence Resonance Energy Transfer Reveals the Adrenocorticotropin (ACTH)-Induced Conformational Change of the Activated ACTH Receptor Complex in Living Cells [PDF]
, 2011 Bioluminescence resonance energy transfer analysis is used to study the interaction between melanocortin 2 receptor (MC2R) accessory protein and the MC2R and provides evidence for protein kinase A-dependent conformational changes in the receptor complex ...
Adrian J. L. Clark +9 more
core +1 more source
Frontiers in Behavioral Neuroscience, 2017 The melanocortin (MC) system regulates feeding and ethanol consumption. Recent evidence shows that melanocortin 4 receptor (MC4-R) stimulation within the nucleus accumbens (NAc) elicits anorectic responses and reduces ethanol consumption and ethanol ...
Francisca Carvajal +7 more
doaj +1 more source
Frontiers in Neuroscience, 2014 The melanocortin (MC) peptides are produced centrally by propiomelanocortin (POMC) neurons within the arcuate nucleus of the hypothalamus and act through five seven-transmembrane G-protein coupled melanocortin receptor (MCR) subtypes.
Jeffrey eOlney +2 more
doaj +1 more source
Cardiovascular effects of melanocortins [PDF]
European Journal of Pharmacology, 2011 Melanocortins (MSH's) are three structurally related peptides derived from proopiomelanocortin. They regulate several physiologic functions including energy metabolism, appetite, and inflammation. Recent work in rodents has also identified important effects of MSH's, particularly γ-MSH, on sodium metabolism and blood pressure regulation.
Michael H, Humphreys +2 more
openaire +2 more sources
Melanocortin peptides protect chondrocytes from mechanically induced cartilage injury [PDF]
, 2014 Mechanical injury can greatly influence articular cartilage, propagating inflammation, cell injury and death-risk factors for the development of osteoarthritis.
Curley, G.P. +11 more
core +1 more source
Probing the Role of Melanocortin Type 1 Receptor Agonists in Diverse Immunological Diseases
Frontiers in Pharmacology, 2019 Background: The melanocortin α-melanocyte stimulating hormone (α-MSH), an endogenous peptide with high affinity for the melanocortin 1 receptor (MC1r), has demonstrated prevention and reversal of intestinal and ocular inflammation in animal models ...
Carl Spana +5 more
doaj +1 more source
Endogenous melanocortin antagonist in fish: Structure, brain mapping and regulation by fasting of the goldfish agouti-related protein gene [PDF]
, 2003 Agouti-related protein (AGRP) is a naturally occurring antagonist of melanocortin. In mammals, central AGRP expression is restricted to the arcuate nucleus in which it plays a key role in the control of energy balance by antagonizing melanocortin effects
Peter, R.E., Cerdá-Reverter, J.M.
core +1 more source