Results 21 to 30 of about 57,827 (240)

IMPROVE 2025: The 3rd International Meeting on Pathway-Related Obesity: Vision & Evidence. [PDF]

Clin Obes
ABSTRACT An international cohort of 161 clinicians and researchers from 19 countries attended the 3rd International Meeting on Pathway‐Related Obesity: Vision & Evidence (IMPROVE) in Prague, Czech Republic, on 2–4 July 2025. The aims of the meeting were to advance understanding of hyperphagia and obesity caused by defects in the melanocortin‐4 receptor
Argente J, van den Akker ELT, Cetiner M, Clément K, Forsythe E, Garfield A, Kühnen P, Martos-Moreno GÁ, Meeker D, Müller HL, van Santen HM, von Schnurbein J, Segrestin B, Tanaka T, Tena-Sempere M, Wabitsch M, Zorn S, Farooqi IS.   +17 more
europepmc   +2 more sources

Evolutionary aspects in evaluating mutations in the melanocortin 4 receptor [PDF]

, 2007
More than 70 missense mutations have been identified in the human melanocortin 4 receptor (MC4R), and many of them have been associated with obesity. In a number of cases, the causal link between mutations in MC4R and obesity is controversially discussed.
Stäubert, Claudia, Tarnow, Patrick, Pitra, Christian, Gudermann, T., Stäubert, C. ; https://orcid.org/, Tarnow, P., Brumm, H., Römpler, Holger, Grüters, A., Biebermann, H., Brumm, Harald, Pitra, C., Gudermann, Thomas, Biebermann, Heike, Schöneberg, T., Schöneberg, Torsten, Römpler, H., Grüters, Annette   +17 more
core   +1 more source

Melanocortin receptors in GtoPdb v.2021.3 [PDF]

, 2021
Melanocortin receptors (provisional nomenclature as recommended by NC-IUPHAR [41]) are activated by members of the melanocortin family (α-MSH, β-MSH and γ-MSH forms; δ form is not found in mammals) and adrenocorticotrophin (ACTH ...
Gantz, Ira, Chai, Biao-Xin, Haskell-Luevano, Carrie, Wikberg, Jarl E. S., Tatro, Jeffrey B., Clark, Adrian J. L., Schiöth, Helgi, Pouton, Colin, Caruso, Vanni, Mountjoy, Kathleen G., Fong, Tung M., Eberle, Alex N., Cone, Roger D., Farooqi, Sadaf, Hruby, Victor J., Carrie Haskell-Luevano, Adrian J. L. Clark, Colin Pouton, Roger D. Cone, Jeffrey B. Tatro, Ira Gantz, Tung M. Fong, Jarl E. S. Wikberg, Vanni Caruso, Biao-Xin Chai, Alex N. Eberle, Sadaf Farooqi, Kathleen G. Mountjoy, Helgi Schiöth, Victor J. Hruby   +29 more
core   +1 more source

Agouti overexpression in a transgenic model regulates integrity, permeability and electrogenic amino acid transport in zebrafish intestine

Frontiers in Marine Science, 2022
Overexpression of asip1 in transgenic zebrafish disrupts dorsoventral pigment pattern in addition to increasing food intake levels and linear growth. A higher feed intake is unnecessary in transgenic fish to enable larger and heavier growth.
Esther Leal, Anna Rita Angotzi, Alejandra Godino-Gimeno, Silvia F. Gregório, Josep Rotllant, Alfonso Saera-Vila, Juan Fuentes, José Miguel Cerdá-Reverter   +7 more
doaj   +1 more source

Anti-melanocortin-4 receptor autoantibodies in obesity [PDF]

, 2009
Background: The melanocortin-4 receptor (MC4R) is part of an important pathway regulating energy balance. Here we report the existence of autoantibodies (autoAbs) against the MC4R in sera of obese patients.
Kessler, L., Muller, Sylviane, Lecourt, Anne-Catherine, Bekel, Akkiz, Bekel, A., Zipfel, G., Peter, J. C., Kessler, Laurence, Eftekhari, Pierre, Eftekhari, P., Zipfel, Géraldine, Hofbauer, Karl G, Breidert, M., Breidert, Matthias, Lecourt, A. C., Muller, S., Nesslinger, Maya, Hofbauer, K. G., Nesslinger, M., Peter, Jean-Christophe, Peter JC, Kessler L, Muller S, Zipfel G, Breidert M, Nesslinger M, Eftekhari P, Lecourt AC, Hofbauer KG, Bekel A   +29 more
core   +1 more source

Thematic review series: Adipocyte Biology. Sympathetic and sensory innervation of white adipose tissue

Journal of Lipid Research, 2007
During our study of the reversal of seasonal obesity in Siberian hamsters, we found an interaction between receptors for the pineal hormone melatonin and the sympathetic nervous system (SNS) outflow from brain to white adipose tissue (WAT).
Timothy J. Bartness, C.K. Song
doaj   +1 more source

Differential effects of melanocortin peptides on neural melanocortin receptors.

Molecular Pharmacology, 1994
Melanocortins (MCs) have various physiological actions on the brain. The recent cloning of neural MC receptors opened new avenues to study the effects of these neuropeptides on the nervous system. Here we investigated the structure-activity relationships (SARs) of peptides derived from adrenocorticotropic hormone (ACTH) with cloned MC3 and MC4 ...
Gispen, W.H., Adan, R.A.H., Cone, R.D., Burbach, J.P.H.   +3 more
openaire   +4 more sources

Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances [PDF]

, 2007
The hypothalamic melanocortin system is crucial for the control of appetite and body weight. Two of the five melanocortin receptors, MC3R and MC4R are involved in hypothalamic control of energy homeostasis, with the MC4R having the major influence. It is
Hisadome, Kazunari, Michael L. J. Ashford, Smith, Mark A., Helen Heffron, Mark A. Smith, Al-Qassab, Hind, Kazunari Hisadome, Withers, Dominic J., Hind Al‐Qassab, Dominic J. Withers, Ashford, Michael L. J.; id_orcid, Heffron, Helen   +11 more
core   +1 more source

Novel anti-inflammatory and chondroprotective effects of the human melanocortin MC1 receptor agonist BMS-470539 dihydrochloride and human melanocortin MC3 receptor agonist PG-990 on lipopolysaccharide activated chondrocytes [PDF]

, 2020
Human melanocortin MC1 and MC3 receptors expressed on C-20/A4 chondrocytes exhibit chondroprotective and anti-inflammatory effects when activated by melanocortin peptides.
De Pascale, C., Kerrigan, MJP, De Pascale, C, Grieco, P, Kerrigan, M.J.P., Grieco, P., Merlino, F, Can, V., Kaneva, MK, Getting, SJ, Merlino, F., Can, VC, Kaneva, M., Locke, IC, Locke, I.C., Getting, S.J., Getting S. J., De Pascale C., Grieco P., Kaneva M. K., Can V. C., Kerrigan M. J. P., Merlino F., Locke I. C.   +23 more
core   +1 more source

The Melanocortin Receptor Accessory Protein 2 promotes food intake through inhibition of the Prokineticin Receptor-1

eLife, 2016
The Melanocortin Receptor Accessory Protein 2 (MRAP2) is an important regulator of energy homeostasis and its loss causes severe obesity in rodents. MRAP2 mediates its action in part through the potentiation of the MC4R, however, it is clear that MRAP2 ...
Anna L Chaly, Dollada Srisai, Ellen E Gardner, Julien A Sebag   +3 more
doaj   +1 more source