Results 21 to 30 of about 48,562 (195)

Differential effects of melanocortin peptides on neural melanocortin receptors.

Molecular Pharmacology, 1994
Melanocortins (MCs) have various physiological actions on the brain. The recent cloning of neural MC receptors opened new avenues to study the effects of these neuropeptides on the nervous system. Here we investigated the structure-activity relationships (SARs) of peptides derived from adrenocorticotropic hormone (ACTH) with cloned MC3 and MC4 ...
Gispen, W.H., Adan, R.A.H., Cone, R.D., Burbach, J.P.H.   +3 more
openaire   +4 more sources

Posttranslational modifications of proopiomelanocortin in vertebrates and their biological significance

Frontiers in Endocrinology, 2013
Proopiomelanocortin (POMC) is the precursor of several peptide hormones generated in the pituitary gland. After biosynthesis, POMC undergoes several posttranslational modifications, including proteolytic cleavage, acetylation, amidation, phosphorylation,
Akiyoshi eTakahashi, Kanta eMizusawa
doaj   +1 more source

Remapping the Synthetic Landscape of α‐Tertiary Alkylamines via Dual‐Functional Catechol

Angewandte Chemie, EarlyView.
A three‐component assembly strategy has been developed for the modular synthesis of hindered α‐tertiary aliphatic amines from readily available precursors through unlocking the dual role of catechol. The practicality of this methodology has been demonstrated in over 90 examples, including compounds that are otherwise difficult to access, along with ...
Chen‐Yan Cai, Yuzuru Kanda, Tian Qin
wiley   +2 more sources

Nucleus Accumbens MC4-R Stimulation Reduces Food and Ethanol Intake in Adult Rats Regardless of Binge-Like Ethanol Exposure during Adolescence

Frontiers in Behavioral Neuroscience, 2017
The melanocortin (MC) system regulates feeding and ethanol consumption. Recent evidence shows that melanocortin 4 receptor (MC4-R) stimulation within the nucleus accumbens (NAc) elicits anorectic responses and reduces ethanol consumption and ethanol ...
Francisca Carvajal, José M. Lerma-Cabrera, José M. Lerma-Cabrera, Manuel Alcaraz-Iborra, Montserrat Navarro, Todd E. Thiele, Inmaculada Cubero, Inmaculada Cubero   +7 more
doaj   +1 more source

Targeting central melanocortin receptors: a promising novel approach for treating alcohol abuse disorders

Frontiers in Neuroscience, 2014
The melanocortin (MC) peptides are produced centrally by propiomelanocortin (POMC) neurons within the arcuate nucleus of the hypothalamus and act through five seven-transmembrane G-protein coupled melanocortin receptor (MCR) subtypes.
Jeffrey eOlney, Montserrat eNavarro, Todd Eric Thiele   +2 more
doaj   +1 more source

Probing the Role of Melanocortin Type 1 Receptor Agonists in Diverse Immunological Diseases

Frontiers in Pharmacology, 2019
Background: The melanocortin α-melanocyte stimulating hormone (α-MSH), an endogenous peptide with high affinity for the melanocortin 1 receptor (MC1r), has demonstrated prevention and reversal of intestinal and ocular inflammation in animal models ...
Carl Spana, Andrew W. Taylor, David G. Yee, Marie Makhlina, Wei Yang, John Dodd   +5 more
doaj   +1 more source

Neurobiology of inflammation-associated anorexia

Frontiers in Neuroscience, 2010
Compelling data demonstrate that inflammation-associated anorexia directly results from the action of pro-inflammatory factors, primarily cytokines and prostaglandins E2, on the nervous system.
Laurent Gautron, Sophie Laye
doaj   +1 more source

L-Cell Expression of Melanocortin-4-Receptor Is Marginal in Most of the Small Intestine in Mice and Humans and Direct Stimulation of Small Intestinal Melanocortin-4-Receptors in Mice and Rats Does Not Affect GLP-1 Secretion

Frontiers in Endocrinology, 2021
The molecular sensors underlying nutrient-stimulated GLP-1 secretion are currently being investigated. Peripheral administration of melanocortin-4 receptor (MC4R) agonists have been reported to increase GLP-1 plasma concentrations in mice and humans but ...
Rune E. Kuhre, Rune E. Kuhre, Rune E. Kuhre, Ida M. Modvig, Ida M. Modvig, Sara L. Jepsen, Sara L. Jepsen, Hüsün S. Kizilkaya, Cecilie Bæch-Laursen, Cecilie Bæch-Laursen, Christopher A. Smith, Frank Reimann, Fiona M. Gribble, Mette M. Rosenkilde, Jens J. Holst, Jens J. Holst   +15 more
doaj   +1 more source

Subdiaphragmatic Vagotomy With Pyloroplasty Ameliorates the Obesity Caused by Genetic Deletion of the Melanocortin 4 Receptor in the Mouse

Frontiers in Neuroscience, 2018
Background/Objectives: We tested the hypothesis that abolishing vagal nerve activity will reverse the obesity phenotype of melanocortin 4 receptor knockout mice (Mc4r−/−).Subjects/Methods: In two separate studies, we examined the efficacy of bilateral ...
Ghazaul Dezfuli, Richard A. Gillis, Jaclyn E. Tatge, Kimbell R. Duncan, Kenneth L. Dretchen, Patrick G. Jackson, Joseph G. Verbalis, Niaz Sahibzada   +7 more
doaj   +1 more source

Histaminergic regulation of food intake

Frontiers in Endocrinology, 2023
Histamine is a biogenic amine that acts as a neuromodulator within the brain. In the hypothalamus, histaminergic signaling contributes to the regulation of numerous physiological and homeostatic processes, including the regulation of energy balance ...
Axelle Khouma, Axelle Khouma, Moein Minbashi Moeini, Moein Minbashi Moeini, Julie Plamondon, Denis Richard, Denis Richard, Alexandre Caron, Alexandre Caron, Alexandre Caron, Natalie Jane Michael, Natalie Jane Michael   +11 more
doaj   +1 more source