The melanocortin receptors and their accessory proteins [PDF]
Frontiers in Endocrinology, 2013 The five melanocortin receptors named MC1R-MC5R have diverse physiological roles encompassing pigmentation, steroidogenesis, energy homeostasis and feeding behaviour as well as exocrine function.
Shwetha eRamachandrappa +3 more
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Melanocortins, Melanocortin Receptors and Multiple Sclerosis [PDF]
Brain Sciences, 2017 The melanocortins and their receptors have been extensively investigated for their roles in the hypothalamo-pituitary-adrenal axis, but to a lesser extent in immune cells and in the nervous system outside the hypothalamic axis.
Robert P. Lisak, Joyce A. Benjamins
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Data for amino acid alignment of Japanese stingray melanocortin receptors with other gnathostome melanocortin receptor sequences, and the ligand selectivity of Japanese stingray melanocortin receptors [PDF]
Data in Brief, 2016 This article contains structure and pharmacological characteristics of melanocortin receptors (MCRs) related to research published in “Characterization of melanocortin receptors from stingray Dasyatis akajei, a cartilaginous fish” (Takahashi et al., 2016)
Akiyoshi Takahashi +5 more
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Ligands for Melanocortin Receptors: Beyond Melanocyte-Stimulating Hormones and Adrenocorticotropin [PDF]
Biomolecules, 2022 The discovery of melanocortins in 1916 has resulted in more than 100 years of research focused on these peptides. Extensive studies have elucidated well-established functions of melanocortins mediated by cell surface receptors, including MSHR (melanocyte-
Xiao-Chen Yuan, Ya-Xiong Tao
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The Importance of Melanocortin Receptors and Their Agonists in Pulmonary Disease [PDF]
Frontiers in Medicine, 2019 Melanocortin agonists are ancient neuropeptides that have steroidogenesis and anti-inflammatory properties. They activate melanocortin receptors (MCR), a family of five seven-transmembrane G-protein coupled receptors. MC1R and MC3R are mainly involved in
Anna Elizabeth Moscowitz +6 more
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Melanocortin 4 receptor signaling in Sim1 neurons permits sexual receptivity in female mice [PDF]
Frontiers in Endocrinology, 2023 IntroductionFemale sexual dysfunction affects approximately 40% of women in the United States, yet few therapeutic options exist for these patients. The melanocortin system is a new treatment target for hypoactive sexual desire disorder (HSDD), but the ...
Erin A. Semple +9 more
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The melanocortin receptors as targets for general obesity: contextualizing clinical failures and analyzing future perspectives [PDF]
Frontiers in EndocrinologyThe melanocortin system is a genetically conserved and clinically validated target for the treatment of obesity. Hundreds of studies establish the role of the melanocortin receptors, particularly the melanocortin-4 receptor, in food intake, weight ...
Claudia R. Prindle +7 more
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Pharmacological modulation of MRAP2 protein on melanocortin receptors in the sea lamprey [PDF]
Endocrine Connections, 2019 Melanocortin receptors (MCRs) and their accessory proteins (MRA Ps) evolutionarily first appear in the genome of sea lamprey. The most ancient melanocortin system consists of only two melanocortin receptors (slMCa and slMCb) and one MRAP2 (slMRAP2 ...
Ming Zhu +5 more
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Activation of Melanocortin Receptors as a Potential Strategy to Reduce Local and Systemic Reactions Induced by Respiratory Viruses [PDF]
Frontiers in Endocrinology, 2020 The clinical hallmarks of infections caused by critical respiratory viruses consist of pneumonia, which can progress to acute lung injury (ALI), and systemic manifestations including hypercoagulopathy, vascular dysfunction, and endotheliitis. The disease
Caterina Lonati +2 more
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Are Melanocortin Receptors Present in Extant Protochordates? [PDF]
BiomoleculesFunctional melanocortin receptor (MCR) genes have been identified in the genomes of early chordates, e.g., the cyclostomata. Whether they appear in the most ancient chordates such as cephalochordate and urochordata, however, remains unclear due to ...
Ren-Lei Ji +4 more
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