Results 41 to 50 of about 44,230 (269)
Molecular Metabolism, 2020 Objective: Histaminergic neurons of the tuberomammillary nucleus (TMN) are wake-promoting and contribute to the regulation of energy homeostasis. Evidence indicates that melanocortin 4 receptors (MC4R) are expressed within the TMN.
Natalie J. Michael +7 more
doaj +1 more source
Frontiers in Immunology, 2022 Rheumatoid arthritis (RA) is a chronic inflammatory disease that leads to joint damage and even disability. Although there are various clinical therapies for RA, some patients still have poor or no response.
Jianan Zhao +26 more
doaj +1 more source
The Melanocortin-4 Receptor Integrates Circadian Light Cues and Metabolism [PDF]
, 2015 The melanocortin system directs diverse physiological functions from coat color to body weight homoeostasis. A commonality among melanocortin-mediated processes is that many animals modulate similar processes on a circannual basis in response to longer ...
Arble, Deanna M. +10 more
core +2 more sources
Ring finger protein 11 inhibits melanocortin 3 and 4 receptor signaling
Frontiers in Endocrinology, 2016 Intact melanocortin signaling via the G protein-coupled receptors (GPCRs) melanocortin receptor 4 (MC4R) and melanocortin receptor 3 (MC3R) is crucial for body weight maintenance.
Anne Müller +16 more
doaj +1 more source
Lateral septum as a melanocortin downstream site in obesity development
Cell Reports, 2023 Summary: The melanocortin pathway is well established to be critical for body-weight regulation in both rodents and humans. Despite extensive studies focusing on this pathway, the downstream brain sites that mediate its action are not clear.
Yuanzhong Xu +8 more
doaj +1 more source
The evolution and comparative neurobiology of endocannabinoid signalling [PDF]
, 2012 CB(1)- and CB(2)-type cannabinoid receptors mediate effects of the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide in mammals. In canonical endocannabinoid-mediated synaptic plasticity, 2-AG is generated postsynaptically by diacylglycerol ...
Devane W. A. +4 more
core +1 more source
Multiple sclerosis, relapses, and the mechanism of action of adrenocorticotropic hormone (ACTH)
Frontiers in Neurology, 2013 Relapses in multiple sclerosis (MS) are disruptive and frequently disabling for patients, and their treatment is often a challenge to clinicians. Despite progress in the understanding of the pathophysiology of MS and development of new treatments for ...
Amy ePerrin Ross +3 more
doaj +1 more source
Differential effects of melanocortin peptides on neural melanocortin receptors.
Molecular Pharmacology, 1994 Melanocortins (MCs) have various physiological actions on the brain. The recent cloning of neural MC receptors opened new avenues to study the effects of these neuropeptides on the nervous system. Here we investigated the structure-activity relationships (SARs) of peptides derived from adrenocorticotropic hormone (ACTH) with cloned MC3 and MC4 ...
Gispen, W.H. +3 more
openaire +4 more sources
Endocrinologic Control of Men's Sexual Desire and Arousal/Erection [PDF]
, 2016 Several hormones and neurotransmitters orchestrate men's sexual response, including the appetitive (sexual desire) and consummative (arousal and penile erection) phases.
Aversa, Antonio +4 more
core +1 more source
Adiponectin potentiates the acute effects of leptin in arcuate Pomc neurons
Molecular Metabolism, 2016 Objective: Adiponectin receptors (AdipoRs) are located on neurons of the hypothalamus involved in metabolic regulation – including arcuate proopiomelanocortin (Pomc) and Neuropeptide Y/Agouti-related peptide (NPY/AgRP) neurons.
Jia Sun +14 more
doaj +1 more source