Are Melanocortin Receptors Present in Extant Protochordates? [PDF]
BiomoleculesFunctional melanocortin receptor (MCR) genes have been identified in the genomes of early chordates, e.g., the cyclostomata. Whether they appear in the most ancient chordates such as cephalochordate and urochordata, however, remains unclear due to ...
Ren-Lei Ji +4 more
doaj +2 more sources
Editorial: Melanocortins and melanocortin receptors in the regulation of inflammation: mechanisms and novel therapeutic strategies. [PDF]
Front Immunol, 2023 Rinne P, Taylor AW, Montero-Melendez T.
europepmc +3 more sources
Cellular signatures of melanocortin pathway genes across the locus coeruleus [PDF]
Acta Neuropathologica CommunicationsObesity and Alzheimer’s disease (AD) are epidemiologically associated. The locus coeruleus (LC)—the brain’s primary and most significant source of norepinephrine—is one of the earliest sites of neurodegeneration in AD.
Alisha Basak +25 more
doaj +2 more sources
Structure elucidation of a human melanocortin-4 receptor specific orthosteric nanobody agonist [PDF]
Nature CommunicationsThe melanocortin receptor 4 (MC4R) belongs to the melanocortin receptor family of G-protein coupled receptors and is a key switch in the leptin-melanocortin molecular axis that controls hunger and satiety.
Thomas Fontaine +21 more
doaj +2 more sources
Polymorphism of Melanocortin Receptor Genes—Association with Inflammatory Traits and Diseases [PDF]
DiseasesMelanocortin receptors (MCRs) are responsible for various functions ranging from skin pigmentation, regulation of appetite, stress response and cognition, steroid synthesis, and energy balance to cellular regeneration and immunomodulation.
Mainak Bardhan +12 more
doaj +2 more sources
The Melanocortin receptors [PDF]
Acta Ophthalmologica Scandinavica, 2001 Morten Møller
openalex +2 more sources
Melanocortin System in Kidney Homeostasis and Disease: Novel Therapeutic Opportunities
Frontiers in Physiology, 2021 Melanocortin peptides, melanocortin receptors, melanocortin receptor accessory proteins, and endogenous antagonists of melanocortin receptors are the key components constituting the melanocortin hormone system, one of the most complex and important ...
Mingyang Chang +4 more
doaj +1 more source
Melanocortin receptor 3 and 4 mRNA expression in the adult female Syrian hamster brain
Frontiers in Molecular Neuroscience, 2023 Melanocortin 3 receptors (MC3R) and melanocortin 4 receptors (MC4R) are vital in regulating a variety of functions across many species. For example, the dysregulation of these receptors results in obesity and dysfunction in sexual behaviors.
Megan A. L. Hall +6 more
doaj +1 more source
Synthesis and Structure–Activity Relationships of Substituted Urea Derivatives on Mouse Melanocortin Receptors [PDF]
ACS Chemical Neuroscience, 2016 Carrie Haskell-Luevano
exaly +2 more sources
Identification of novel GPCR partners of the central melanocortin signaling
Molecular Metabolism, 2021 Objective: Homo- or heterodimerization of G protein–coupled receptors (GPCRs) generally alters the normal functioning of these receptors and mediates their responses to a variety of physiological stimuli in vivo.
Yunpeng Li +13 more
doaj +1 more source