Results 11 to 20 of about 44,230 (269)

Editorial: Melanocortins and melanocortin receptors in the regulation of inflammation: mechanisms and novel therapeutic strategies. [PDF]

Front Immunol, 2023
Rinne P, Taylor AW, Montero-Melendez T.
europepmc   +3 more sources

Melanocortin receptors in leptin effects [PDF]

Nature, 1997
Leptin acts on the central nervous system to cause a reduction in food intake and body weight1,2. The melanocortin system in the brain is also implicated in energy homeostasis, with agonists of the melanocortin-4 (MC4) receptor reducing food intake3 and targeted mutation of the MC4 receptor causing obesity4.
Seeley, Randy J., Yagaloff, Keith A., Fisher, Stewart L., Burn, Paul, Thiele, Todd E., Dijk, Gertjan van, Baskin, Denis G., Schwartz, Michael W.   +7 more
openaire   +5 more sources

Cellular signatures of melanocortin pathway genes across the locus coeruleus [PDF]

Acta Neuropathologica Communications
Obesity and Alzheimer’s disease (AD) are epidemiologically associated. The locus coeruleus (LC)—the brain’s primary and most significant source of norepinephrine—is one of the earliest sites of neurodegeneration in AD.
Alisha Basak, Fahrünisa Meryem Betül Erol, Maria Caterina De Rosa, Zhangji Dong, Victor Ogbolu, Hannah J. Glover, Rick Rausch, Gunnar Hargus, Jordi Creus-Muncunill, Heather Buchanan, Yu Bai, Qi Su, Betty Chang, Christina Adler, Delaney Flaherty, Benjamin Ciener, Harrison Xiao, Hasini Reddy, Pascaline Aime-Wilson, Christiane Reitz, Mark W. Sleeman, Judith Y. Altarejos, Rudolph L. Leibel, Liang Oscar Qiang, Andrew F. Teich, Claudia A. Doege   +25 more
doaj   +2 more sources

Modulation of social behavior by the agouti pigmentation gene [PDF]

Frontiers in Behavioral Neuroscience, 2014
Agouti is a secreted neuropeptide that acts as an endogenous antagonist of melanocortin receptors. Mice and rats lacking agouti (called non-agouti) have dark fur due to a disinhibition of melanocortin signaling and pigment deposition in the hair follicle.
Valeria eCarola, Emerald ePerlas, Francesca eZonfrillo, Helena A Soini, Milos V Novotny, Cornelius eGross   +5 more
doaj   +3 more sources

Melanocortin 3 Receptors Do Not Specifically Localize to Primary Cilia in Cultured Human and Rodent Neurons. [PDF]

Cell Biochem Funct
ABSTRACT The melanocortin‐3 receptor (MC3R) and the melanocortin‐4 receptor (MC4R), both expressed in hypothalamic nuclei, are key downstream effectors of leptin signaling and play important roles in energy homeostasis. While pathogenic variants in the MC4R gene represent the most common cause of monogenic obesity, the clinical significance of MC3R ...
Vos N, Moro A, Hul WV, Kleinendorst L, Florijn RJ, la Fleur SE, Verhage M, van Haelst MM, Toonen RF.   +8 more
europepmc   +2 more sources

Polymorphism of Melanocortin Receptor Genes—Association with Inflammatory Traits and Diseases [PDF]

Diseases
Melanocortin receptors (MCRs) are responsible for various functions ranging from skin pigmentation, regulation of appetite, stress response and cognition, steroid synthesis, and energy balance to cellular regeneration and immunomodulation.
Mainak Bardhan, Ayush Anand, Amaan Javed, Maria Andrea Chilo, Nida Khan, Tulika Garg, Arihant Surana, Helen Huang, M M Samim, Vinay Suresh, Abhinav Khare, Bindu Menon, Tithishri Kundu   +12 more
doaj   +2 more sources

Structure elucidation of a human melanocortin-4 receptor specific orthosteric nanobody agonist [PDF]

Nature Communications
The melanocortin receptor 4 (MC4R) belongs to the melanocortin receptor family of G-protein coupled receptors and is a key switch in the leptin-melanocortin molecular axis that controls hunger and satiety.
Thomas Fontaine, Andreas Busch, Toon Laeremans, Stéphane De Cesco, Yi-Lynn Liang, Veli-Pekka Jaakola, Zara Sands, Sarah Triest, Simonas Masiulis, Lies Dekeyzer, Noor Samyn, Nicolas Loeys, Lisa Perneel, Melanie Debaere, Murielle Martini, Charlotte Vantieghem, Richa Virmani, Kamila Skieterska, Stephanie Staelens, Rosa Barroco, Maarten Van Roy, Christel Menet   +21 more
doaj   +2 more sources

Pathophysiology of melanocortin receptors and their accessory proteins. [PDF]

Best Practice and Research in Clinical Endocrinology and Metabolism, 2018
The melanocortin receptors (MCRs) and their accessory proteins (MRAPs) are involved in regulation of a diverse range of endocrine pathways. Genetic variants of these components result in phenotypic variation and disease. The MC1R is expressed in skin and
A.J.L. Clark, Anderson, Asai, Balthasar, Begriche, Benjannet, Bishop, Box, Buggy, Bultman, Butler, Butler, Böhm, Chakraborty, Chaly, Chan, Chan, Chan, Chen, Chen, Chen, Cheung, Chida, Chung, Chung, Clark, Clark, Clark, Clark, Coll, Collet, Cone, Cone, Cooray, Cooray, Cooray, Cui, D'Orazio, do Carmo, Elias, Enriori, Farooqi, Feng, Flier, Friedman, Gee, Ghamari-Langroudi, Girardet, Gonzalez-Rey, Gorrigan, Greenfield, Huszar, Jarrett, Kievit, Kim, L.F. Chan, Landi, Lee, Lee, Lembertas, Lim, Lovett, Lowry, Lu, Manceau, Markison, Marks, Marsh, Martinelli, Metherell, Metherell, Miller, Mirshahi, Morgan, Morgan, Morgan, Mountjoy, Mountjoy, Ni, Nimura, Novoselova, O'Rahilly, Ogawa, Ollmann, Padilla, Palmer, Pasquali, Pelleymounter, Raadsheer, Rached, Raimondi, Robbins, Robles-Espinoza, Rodrigues, Roselli-Rehfuss, Rouault, Roy, Schauer, Scott, Sebag, Sebag, Shen, Shenker, Simamura, Smith, Smith, Sohn, Srisai, Swords, T.V. Novoselova, Tao, Turan, Ulrich-Lai, Vaisse, Valverde, Vinson, Webb, Webb, Weber, Williams, Xu, Xu, Yang, Yeo, Young, Zhang, Zhang   +126 more
core   +4 more sources

The Multifaceted Melanocortin Receptors.

Endocrinology, 2022
AbstractThe 5 known melanocortin receptors (MCs) have established physiological roles. With the exception of MC2, these receptors can behave unpredictably, and since they are more widely expressed than their established roles would suggest, it is likely that they have other poorly characterized functions.
Laiho L, Murray JF.
europepmc   +4 more sources

ACTH antagonists [PDF]

Frontiers in Endocrinology, 2016
ACTH acts via a highly selective receptor that is a member of the melanocortin receptor subfamily of type 1 G protein-coupled receptors. The ACTH receptor, also known as the melanocortin 2 receptor (MC2R) is unusual in that it is absolutely dependent on ...
Adrian John Clark, Li Chan, Mashal Hussain, Rachel Forfar, Jeff Jerman, Ed McIver, Debra Taylor   +6 more
doaj   +5 more sources