The Multifaceted Melanocortin Receptors [PDF]
Endocrinology, 2022 AbstractThe 5 known melanocortin receptors (MCs) have established physiological roles. With the exception of MC2, these receptors can behave unpredictably, and since they are more widely expressed than their established roles would suggest, it is likely that they have other poorly characterized functions.
Joanne Murray
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MOLECULAR EVOLUTION OF GPCRS: Melanocortin/melanocortin receptors [PDF]
Journal of Molecular Endocrinology, 2014 The melanocortin receptors (MCRs) are a family of G protein-coupled receptors that are activated by melanocortin ligands derived from the proprotein, proopiomelanocortin (POMC). During the radiation of the gnathostomes, the five receptors have become functionally segregated (i.e.
Robert M, Dores +5 more
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Observations on the evolution of the melanocortin receptor gene family: distinctive features of the melanocortin-2 receptor [PDF]
Frontiers in Neuroscience, 2013 The melanocortin receptors are a gene family in the rhodopsin class of G protein-coupled receptors. Based on the analysis of several metazoan genome databases it appears that the melanocortin receptors are only found in chordates.
Robert Michael Dores
doaj +3 more sources
Involvement of melanocortin receptor accessory proteins (MRAPs) in the function of melanocortin receptors [PDF]
General and Comparative Endocrinology, 2013 The melanocortin system integrates different agonists, competitive or inverse agonists, and receptors. Recent investigations have also discovered a specific system of melanocortin receptor accessory proteins (MRAPs) that are involved in the regulation of the functional expression of these receptors.
Cerdá-Reverter, José Miguel +8 more
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“Are melanocortin receptors constitutively active in vivo?” [PDF]
European Journal of Pharmacology, 2013 Constitutive activity is defined as ligand-independent activity, resulting in the production of a second messenger, even in the absence of an agonist. There has been widespread acceptance of the concept of G-protein-coupled receptor constitutive activity, with this activity specifically blocked by inverse agonists, a particular class of ligands often ...
Coll, Anthony P.
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Melanocortin System in Kidney Homeostasis and Disease: Novel Therapeutic Opportunities
Frontiers in Physiology, 2021 Melanocortin peptides, melanocortin receptors, melanocortin receptor accessory proteins, and endogenous antagonists of melanocortin receptors are the key components constituting the melanocortin hormone system, one of the most complex and important ...
Mingyang Chang +4 more
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Melanocortin receptor 3 and 4 mRNA expression in the adult female Syrian hamster brain
Frontiers in Molecular Neuroscience, 2023 Melanocortin 3 receptors (MC3R) and melanocortin 4 receptors (MC4R) are vital in regulating a variety of functions across many species. For example, the dysregulation of these receptors results in obesity and dysfunction in sexual behaviors.
Megan A. L. Hall +6 more
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Identification of novel GPCR partners of the central melanocortin signaling
Molecular Metabolism, 2021 Objective: Homo- or heterodimerization of G protein–coupled receptors (GPCRs) generally alters the normal functioning of these receptors and mediates their responses to a variety of physiological stimuli in vivo.
Yunpeng Li +13 more
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Synthesis and Structure–Activity Relationships of Substituted Urea Derivatives on Mouse Melanocortin Receptors [PDF]
ACS Chemical Neuroscience, 2016 Carrie Haskell-Luevano
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The melanocortin pathway and energy homeostasis: From discovery to obesity therapy
Molecular Metabolism, 2021 Background: Over the past 20 years, insights from human and mouse genetics have illuminated the central role of the brain leptin-melanocortin pathway in controlling mammalian food intake, with genetic disruption resulting in extreme obesity, and more ...
Giles S.H. Yeo +14 more
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