Specific Functions of Melanocortin 3 Receptor (MC3R) [PDF]
JCRPE, 2023 Melanocortin 3 receptor (MC3R) is a G-protein coupled receptor which has been defined mostly as a regulator of the appetite/hunger balance mechanisms to date.
Tulin Yanik, Seyda Tugce Durhan
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Melanocortin 3 receptor regulates hepatic autophagy and systemic adiposity [PDF]
Nature CommunicationsSystemic lipid homeostasis requires hepatic autophagy, a major cellular program for intracellular fat recycling. Here, we find melanocortin 3 receptor (MC3R) regulates hepatic autophagy in addition to its previously established CNS role in systemic ...
Tushar P. Patel +17 more
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Functional Characterization of Melanocortin-3 Receptor in a Hibernating Cavefish Onychostoma macrolepis [PDF]
Animals, 2021 Melanocortin-3 receptor (MC3R) plays an important role in the energy homeostasis of animals under different nutritional conditions. Onychostoma macrolepis is a hibernating cavefish found in the northern part of the Yangtze River, and its adaptation to a ...
Lian Wu +8 more
doaj +5 more sources
Topmouth culter melanocortin-3 receptor: regulation by two isoforms of melanocortin-2 receptor accessory protein 2 [PDF]
Endocrine Connections, 2021 Melanocortin-3 receptor (MC3R) is a regulator of energy homeostasis, and interaction of MC3R and melanocortin-2 receptor accessory protein 2 (MRAP2) plays a critical role in MC3R signaling of mammals.
Ren-Lei Ji +6 more
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Pharmacological modulation of the cAMP signaling of two isoforms of melanocortin-3 receptor by melanocortin receptor accessory proteins in the tetrapod Xenopus laevis [PDF]
Endocrine Connections, 2021 As a member of the seven-transmembrane rhodopsin-like G protein-coupled receptor superfamily, the melanocortin-3 receptor (MC3R) is vital for the regulation of energy homeostasis and rhythms synchronizing in mammals, and its pharm acological effect could
Ying Xu +12 more
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The melanocortin-3 receptor is a pharmacological target for the regulation of anorexia. [PDF]
Sci Transl Med, 2021 Pharmacological manipulation of the melanocortin-3 receptor bidirectionally controls feeding, providing a therapeutic target for eating disorders.
Sweeney P +14 more
europepmc +3 more sources
Regulation of energy rheostasis by the melanocortin-3 receptor. [PDF]
Sci Adv, 2018 The melanocortin-3 receptor acts as a rheostat on energy homeostasis through presynaptic inhibition of MC4R neuronal activity.
Ghamari-Langroudi M +6 more
europepmc +6 more sources
Biomolecules, 2022 The neural melanocortin receptors (MCRs), melanocortin-3 and -4 receptors (MC3R and MC4R), play essential non-redundant roles in the regulation of energy homeostasis. Interaction of neural MCRs and melanocortin-2 receptor accessory proteins (MRAPs, MRAP1
Ren-Lei Ji, Ya-Xiong Tao
doaj +3 more sources
Biomolecules, 2022 The neural melanocortin receptors (MCRs), melanocortin-3 and -4 receptors (MC3R and MC4R), have crucial roles in regulating energy homeostasis. The melanocortin-2 receptor accessory proteins (MRAPs, MRAP1 and MRAP2) have been shown to regulate neural ...
Ren-Lei Ji +2 more
doaj +3 more sources
Discovery of Novel Potent and Selective Agonists at the Melanocortin-3 Receptor. [PDF]
J Med Chem, 2015 The melanocortin receptors 3 and 4 control energy homeostasis, food-intake behavior, and correlated pathophysiological conditions. The melanocortin-4 receptor (MC4R) has been broadly investigated. In contrast, the knowledge related to physiological roles of the melanocortin-3 receptor (MC3R) is lacking because of the limited number of known MC3R ...
Carotenuto A +7 more
europepmc +5 more sources