Specific Functions of Melanocortin 3 Receptor (MC3R) [PDF]
JCRPE, 2023 Melanocortin 3 receptor (MC3R) is a G-protein coupled receptor which has been defined mostly as a regulator of the appetite/hunger balance mechanisms to date.
Tulin Yanik, Seyda Tugce Durhan
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Melanocortin 3 receptor regulates hepatic autophagy and systemic adiposity [PDF]
Nature CommunicationsSystemic lipid homeostasis requires hepatic autophagy, a major cellular program for intracellular fat recycling. Here, we find melanocortin 3 receptor (MC3R) regulates hepatic autophagy in addition to its previously established CNS role in systemic ...
Tushar P. Patel +17 more
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Ring finger protein 11 inhibits melanocortin 3 and 4 receptor signaling [PDF]
Frontiers in Endocrinology, 2016 Intact melanocortin signaling via the G protein-coupled receptors (GPCRs) melanocortin receptor 4 (MC4R) and melanocortin receptor 3 (MC3R) is crucial for body weight maintenance.
Anne Müller +16 more
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Functional Characterization of Melanocortin-3 Receptor in a Hibernating Cavefish Onychostoma macrolepis [PDF]
Animals, 2021 Melanocortin-3 receptor (MC3R) plays an important role in the energy homeostasis of animals under different nutritional conditions. Onychostoma macrolepis is a hibernating cavefish found in the northern part of the Yangtze River, and its adaptation to a ...
Lian Wu +8 more
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Topmouth culter melanocortin-3 receptor: regulation by two isoforms of melanocortin-2 receptor accessory protein 2 [PDF]
Endocrine Connections, 2021 Melanocortin-3 receptor (MC3R) is a regulator of energy homeostasis, and interaction of MC3R and melanocortin-2 receptor accessory protein 2 (MRAP2) plays a critical role in MC3R signaling of mammals.
Ren-Lei Ji +6 more
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Pharmacological modulation of the cAMP signaling of two isoforms of melanocortin-3 receptor by melanocortin receptor accessory proteins in the tetrapod Xenopus laevis [PDF]
Endocrine Connections, 2021 As a member of the seven-transmembrane rhodopsin-like G protein-coupled receptor superfamily, the melanocortin-3 receptor (MC3R) is vital for the regulation of energy homeostasis and rhythms synchronizing in mammals, and its pharm acological effect could
Ying Xu +12 more
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Regulation of energy rheostasis by the melanocortin-3 receptor. [PDF]
Sci Adv, 2018 The melanocortin-3 receptor acts as a rheostat on energy homeostasis through presynaptic inhibition of MC4R neuronal activity.
Ghamari-Langroudi M +6 more
europepmc +6 more sources
Melanocortin 3 receptor-expressing neurons in the ventromedial hypothalamus promote glucose disposal. [PDF]
Proc Natl Acad Sci U S A, 2021 The ventromedial hypothalamus (VMH) is a critical neural node that senses blood glucose and promotes glucose utilization or mobilization during hypoglycemia. The VMH neurons that control these distinct physiologic processes are largely unknown.
Sutton Hickey AK +6 more
europepmc +4 more sources
Glucose Intake during the Neonatal Period Modulates the Central Melanocortin System with Breed-Specific Differences [PDF]
The Journal of Poultry ScienceGlucose is the primary substrate for cellular energy production, and its blood concentration is tightly regulated. This study investigated the effect of glucose supplementation during the first three days post-hatching on growth performance and ...
Kazuki Kimura +6 more
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The melanocortin receptors as targets for general obesity: contextualizing clinical failures and analyzing future perspectives [PDF]
Frontiers in EndocrinologyThe melanocortin system is a genetically conserved and clinically validated target for the treatment of obesity. Hundreds of studies establish the role of the melanocortin receptors, particularly the melanocortin-4 receptor, in food intake, weight ...
Claudia R. Prindle +7 more
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