Results 31 to 40 of about 46,735 (181)

Implication of the melanocortin-3 receptor in the regulation of food intake [PDF]

European Journal of Pharmacology, 2011
The melanocortin system is well recognized to be involved in the regulation of food intake, body weight, and energy homeostasis. To probe the role of the MC(3) in the regulation of food intake, JRH322-18 a mixed MC(3) partial agonist/antagonist and MC(4) agonist tetrapeptide was examined in wild type (WT) and melanocortin 4 receptor (MC(4)) knockout ...
Boman G, Irani, Zhimin, Xiang, Hossein N, Yarandi, Jerry R, Holder, Marcus C, Moore, Rayna M, Bauzo, Bettina, Proneth, Amanda M, Shaw, William J, Millard, James B, Chambers, Stephen C, Benoit, Deborah J, Clegg, Carrie, Haskell-Luevano   +12 more
openaire   +2 more sources

Role of the Melanocortin System in Gonadal Steroidogenesis of Zebrafish

Animals, 2022
In teleost, as in other vertebrates, stress affects reproduction. A key component of the stress response is the pituitary secretion of the adrenocorticotropic hormone (ACTH), which binds to the melanocortin 2 receptor (MC2R) in the adrenal glands and ...
Sandra Navarro, Diego Crespo, Rüdiger W. Schulz, Wei Ge, Josep Rotllant, José Miguel Cerdá-Reverter, Ana Rocha   +6 more
doaj   +1 more source

Identification of the Translation Start Site of the Human Melanocortin 3 Receptor [PDF]

Obesity Facts, 2012
<i>Background:</i> The melanocortin-3-receptor (MC3R) is a G-protein coupled receptor participating in hypothalamic energy metabolism. So far, it was assumed that the translation of the human MC3R starts at the non-conserved first ATG, however, a second evolutionary conserved ATG is located 37 amino acids downstream.
Patrick, Tarnow, Anne, Rediger, Angela, Schulz, Annette, Grüters, Heike, Biebermann   +4 more
openaire   +2 more sources

Genetic obesity: an update with emerging therapeutic approaches [PDF]

Annals of Pediatric Endocrinology & Metabolism, 2022
Based on the genetic contribution, childhood obesity can be classified into 3 groups: common polygenic obesity, syndromic obesity, and monogenic obesity.
Young Bae Sohn
doaj   +1 more source

Inhibition of the central melanocortin system decreases brown adipose tissue activity[S]

Journal of Lipid Research, 2014
The melanocortin system is an important regulator of energy balance, and melanocortin 4 receptor (MC4R) deficiency is the most common monogenic cause of obesity.
Sander Kooijman, Mariëtte R. Boon, Edwin T. Parlevliet, Janine J. Geerling, Vera van de Pol, Johannes A. Romijn, Louis M. Havekes, Illiana Meurs, Patrick C.N. Rensen   +8 more
doaj   +1 more source

Inhibitory effect of the melanocortin receptor agonist melanotan-II (MTII) on feeding depends on dietary fat content and not obesity in rats on free-choice diets

Frontiers in Behavioral Neuroscience, 2015
Introduction: Conflicting data exist on sensitivity changes of the melanocortin system during diet-induced obesity. We hypothesized that melanocortin sensitivity depends on diet composition, in particular on the fat content rather than the level of ...
José eVan Den Heuvel, Leslie eEggels, Andrea evan Rozen, Eric eFliers, Andries eKalsbeek, Andries eKalsbeek, Roger eAdan, Susanne E la Fleur   +7 more
doaj   +1 more source

Remapping the Synthetic Landscape of α‐Tertiary Alkylamines via Dual‐Functional Catechol

Angewandte Chemie, EarlyView.
A three‐component assembly strategy has been developed for the modular synthesis of hindered α‐tertiary aliphatic amines from readily available precursors through unlocking the dual role of catechol. The practicality of this methodology has been demonstrated in over 90 examples, including compounds that are otherwise difficult to access, along with ...
Chen‐Yan Cai, Yuzuru Kanda, Tian Qin
wiley   +2 more sources

Molecular cloning and pharmacological characterization of porcine melanocortin-3 receptor [PDF]

Journal of Endocrinology, 2007
Mouse gene targeting studies revealed that the melanocortin-3 receptor (MC3R) affected feeding efficiency and fat storage in mice. The functions of the MC3R in other mammalian species remain to be investigated. We are interested in exploring the functions of the porcine MC3R (pMC3R) in regulating fat storage because of the economical importance of ...
Zhen-Chuan, Fan, James L, Sartin, Ya-Xiong, Tao   +2 more
openaire   +2 more sources

The Melanocortin 3 Receptor: A Novel Mediator of Exercise-Induced Inflammation Reduction in Postmenopausal Women?

Journal of Aging Research, 2011
The purpose of this study was to determine whether resistance exercise training-induced reductions in inflammation are mediated via melanocortin 3 receptor expression in obese (BMI 32.7±3.7) women (65.6±2.8 yrs) randomized to either a control (𝑁=11) or ...
Tara M. Henagan, Melody D. Phillips, Dennis J. Cheek, K. Michelle Kirk, James J. Barbee, Laura K. Stewart   +5 more
doaj   +1 more source

Allelic variants of melanocortin 3 receptor gene (MC3R) and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets. [PDF]

PLoS ONE, 2011
INTRODUCTION: The melanocortin system plays an important role in energy homeostasis. Mice genetically deficient in the melanocortin-3 receptor gene have a normal body weight with increased body fat, mild hypophagia compared to wild-type mice.
José L Santos, Rolando De la Cruz, Claus Holst, Katrine Grau, Carolina Naranjo, Alberto Maiz, Arne Astrup, Wim H M Saris, Ian MacDonald, Jean-Michel Oppert, Torben Hansen, Oluf Pedersen, Thorkild I A Sorensen, J Alfredo Martinez, NUGENOB Consortium   +14 more
doaj   +1 more source