Results 11 to 20 of about 58,907 (217)

Cross-species studies implicate the melanocortin 3 receptor more strongly in the control of pubertal development than energy balance [PDF]

Molecular Metabolism
Hypothalamic neurons expressing either POMC or AGRP sense nutritional state directly and indirectly and transmit these neuropeptide signals to other brain centres through the melanocortin 3 and 4 receptors. MC4R is primarily concerned with the control of
Katie Duckett, Alyce McClellan, Laura J. Corbin, Irene Cimino, Ahmed Elhakeem, Ana Goncalves Soares, Alice Williamson, Eloise Cross, Zammy Fairhurst-Hunter, Slavé Petrovski, Debra Rimmington, Jesús Alegre-Díaz, Jaime Berumen, Pablo Kuri-Morales, Roberto Tapia-Conyer, Jacek Mokrosinski, I. Sadaf Farooqi, Asif Rasheed, Danish Saleheen, Adam S. Butterworth, Nicholas J. Timpson, Anthony P. Coll, Eleanor Raffan, Brian Y.H. Lam, Stephen O’Rahilly   +24 more
doaj   +2 more sources

Discovery of Novel Potent and Selective Agonists at the Melanocortin-3 Receptor. [PDF]

J Med Chem, 2015
The melanocortin receptors 3 and 4 control energy homeostasis, food-intake behavior, and correlated pathophysiological conditions. The melanocortin-4 receptor (MC4R) has been broadly investigated. In contrast, the knowledge related to physiological roles of the melanocortin-3 receptor (MC3R) is lacking because of the limited number of known MC3R ...
Carotenuto A, Merlino F, Cai M, Brancaccio D, Yousif AM, Novellino E, Hruby VJ, Grieco P.   +7 more
europepmc   +5 more sources

Evaluation of hypothalamic murine and human melanocortin 3 receptor transcript structure. [PDF]

Biochem Biophys Res Commun, 2014
The melanocortin 3 receptor (MC3R) is involved in regulation of energy homeostasis. However, its transcript structure is not well understood. We therefore studied initiation and termination sites for hypothalamic murine Mc3r and human MC3R transcripts.
Taylor-Douglas DC, Basu A, Gardner RM, Aspelund S, Wen X, Yanovski JA.   +5 more
europepmc   +4 more sources

Functions of DPLIY motif and helix 8 of human melanocortin-3 receptor. [PDF]

J Mol Endocrinol, 2015
The melanocortin-3 receptor (MC3R) is a member of the family A G protein-coupled receptors (GPCRs). The MC3R remains the most enigmatic of the melanocortin receptors with regard to its physiological functions, especially its role in energy homeostasis.
Yang Z, Huang ZL, Tao YX.
europepmc   +4 more sources

Structural Insights into Selective Ligand-Receptor Interactions Leading to Receptor Inactivation Utilizing Selective Melanocortin 3 Receptor Antagonists. [PDF]

Biochemistry, 2017
Systematic N-methylated derivatives of the melanocortin receptor ligand, SHU9119, lead to multiple binding and functional selectivity toward melanocortin receptors. However, the relationship between N-methylation-induced conformational changes in the peptide backbone and side chains and melanocortin receptor selectivity is still unknown.
Cai M, Marelli UK, Mertz B, Beck JG, Opperer F, Rechenmacher F, Kessler H, Hruby VJ.   +7 more
europepmc   +4 more sources

Biased signaling in naturally occurring mutations in human melanocortin-3 receptor gene. [PDF]

Int J Biol Sci, 2015
The melanocortin-3 receptor (MC3R) is primarily expressed in the hypothalamus and plays an important role in the regulation of energy homeostasis. Recently, some studies demonstrated that MC3R also signals through mitogen-activated protein kinases (MAPKs), especially extracellular signal-regulated kinases 1 and 2 (ERK1/2).
Yang F, Huang H, Tao YX.
europepmc   +3 more sources

N-Branched Tricyclic Guanidines as Novel Melanocortin-3 Receptor Agonists and Melanocortin-4 Receptor Antagonists. [PDF]

J Med Chem
The melanocortin receptors are a class of centrally and peripherally expressed G protein-coupled receptors, of which the MC3R and MC4R subtypes are implicated in the regulation of appetite and energy homeostasis and can serve as potential therapeutic targets for disorders such as obesity and cachexia.
Weirath NA, Zajac JWP, Donow HM, Lavoi TM, Pinilla C, Santos RG, Prajapati R, Speth R, Ericson MD, Sarupria S, Giulianotti MA, Haskell-Luevano C.   +11 more
europepmc   +3 more sources

Investigating the role of melanocortinergic, glutamatergic and neuropeptide Y systems on hypophagia caused by gastric inhibitory polypeptide (GIP) in broilers [PDF]

Poultry Science
: Appetite control and the metabolic rate of energy expenditure are under the influence of a broad suite of biochemical messengers, which include peptide-based signals, hormonal agents, and neurotransmitters.
Maryam Lotfi Gharaie, Morteza Zendehdel, Hamed Zarei, Kimia Mahdavi   +3 more
doaj   +2 more sources

Regulation of Melanocortin-3 and -4 Receptors by Isoforms of Melanocortin-2 Receptor Accessory Protein 1 and 2

Biomolecules, 2022
The neural melanocortin receptors (MCRs), melanocortin-3 and -4 receptors (MC3R and MC4R), play essential non-redundant roles in the regulation of energy homeostasis. Interaction of neural MCRs and melanocortin-2 receptor accessory proteins (MRAPs, MRAP1
Ren-Lei Ji, Ya-Xiong Tao
doaj   +1 more source

Modulation of Canine Melanocortin-3 and -4 Receptors by Melanocortin-2 Receptor Accessory Protein 1 and 2

Biomolecules, 2022
The neural melanocortin receptors (MCRs), melanocortin-3 and -4 receptors (MC3R and MC4R), have crucial roles in regulating energy homeostasis. The melanocortin-2 receptor accessory proteins (MRAPs, MRAP1 and MRAP2) have been shown to regulate neural ...
Ren-Lei Ji, Shan-Shan Jiang, Ya-Xiong Tao   +2 more
doaj   +1 more source