Results 11 to 20 of about 46,735 (181)

Polymorphisms and mutations in the melanocortin-3 receptor and their relation to human obesity. [PDF]

Biochim Biophys Acta Mol Basis Dis, 2017
Inactivating mutations in the melanocortin 3 receptor (Mc3r) have been described as causing obesity in mice, but the physiologic effects of MC3R mutations in humans have been less clear. Here we review the MC3R polymorphisms and mutations identified in humans, and the in vitro, murine, and human cohort studies examining their putative effects.
Demidowich AP, Jun JY, Yanovski JA.
europepmc   +3 more sources

Cross-species studies implicate the melanocortin 3 receptor more strongly in the control of pubertal development than energy balance [PDF]

Molecular Metabolism
Hypothalamic neurons expressing either POMC or AGRP sense nutritional state directly and indirectly and transmit these neuropeptide signals to other brain centres through the melanocortin 3 and 4 receptors. MC4R is primarily concerned with the control of
Katie Duckett, Alyce McClellan, Laura J. Corbin, Irene Cimino, Ahmed Elhakeem, Ana Goncalves Soares, Alice Williamson, Eloise Cross, Zammy Fairhurst-Hunter, Slavé Petrovski, Debra Rimmington, Jesús Alegre-Díaz, Jaime Berumen, Pablo Kuri-Morales, Roberto Tapia-Conyer, Jacek Mokrosinski, I. Sadaf Farooqi, Asif Rasheed, Danish Saleheen, Adam S. Butterworth, Nicholas J. Timpson, Anthony P. Coll, Eleanor Raffan, Brian Y.H. Lam, Stephen O’Rahilly   +24 more
doaj   +2 more sources

Ring finger protein 11 inhibits melanocortin 3 and 4 receptor signaling [PDF]

Frontiers in Endocrinology, 2016
Intact melanocortin signaling via the G protein-coupled receptors (GPCRs) melanocortin receptor 4 (MC4R) and melanocortin receptor 3 (MC3R) is crucial for body weight maintenance.
Anne Müller, Lars Niederstadt, Wenke Jonas, Wenke Jonas, Chun-Xia Yi, Franziska Meyer, Petra Wiedmer, Jana Fischer, Carsten Grötzinger, Annette Schürmann, Annette Schürmann, Matthias Tschöp, Matthias Tschöp, Gunnar Kleinau, Annette Grüters, Heiko Krude, Heike Biebermann   +16 more
doaj   +4 more sources

Melanocortin 1 Receptor: Structure, Function and Regulation

Frontiers in Genetics, 2016
The melanocortin 1 receptor (MC1R) is a melanocytic Gs protein coupled receptor that regulates skin pigmentation, UV responses, and melanoma risk. It is a highly polymorphic gene, and loss of function correlates with a fair, UV-sensitive, and melanoma ...
Erin Marissa Wolf Horrell, Mary Catherine Boulanger, John August D'orazio   +2 more
doaj   +3 more sources

Glucose Intake during the Neonatal Period Modulates the Central Melanocortin System with Breed-Specific Differences [PDF]

The Journal of Poultry Science
Glucose is the primary substrate for cellular energy production, and its blood concentration is tightly regulated. This study investigated the effect of glucose supplementation during the first three days post-hatching on growth performance and ...
Kazuki Kimura, Yuuna Watanabe, Sachi Ashizawa, Koichi Matsushita, Nobuhiro Nakao, Yoshiyuki Ohta, Jun-ichi Shiraishi   +6 more
doaj   +2 more sources

Evaluation of hypothalamic murine and human melanocortin 3 receptor transcript structure. [PDF]

Biochem Biophys Res Commun, 2014
The melanocortin 3 receptor (MC3R) is involved in regulation of energy homeostasis. However, its transcript structure is not well understood. We therefore studied initiation and termination sites for hypothalamic murine Mc3r and human MC3R transcripts.
Taylor-Douglas DC, Basu A, Gardner RM, Aspelund S, Wen X, Yanovski JA.   +5 more
europepmc   +4 more sources

The melanocortin receptors as targets for general obesity: contextualizing clinical failures and analyzing future perspectives [PDF]

Frontiers in Endocrinology
The melanocortin system is a genetically conserved and clinically validated target for the treatment of obesity. Hundreds of studies establish the role of the melanocortin receptors, particularly the melanocortin-4 receptor, in food intake, weight ...
Claudia R. Prindle, Thomas L. Bennett, Benjamin H. Rajewski, Kade J. Kelley, Anna C. Impastato, Russell Potterfield, Daniel L. Marks, Jordan Y. Delev   +7 more
doaj   +2 more sources

Functions of DPLIY motif and helix 8 of human melanocortin-3 receptor. [PDF]

J Mol Endocrinol, 2015
The melanocortin-3 receptor (MC3R) is a member of the family A G protein-coupled receptors (GPCRs). The MC3R remains the most enigmatic of the melanocortin receptors with regard to its physiological functions, especially its role in energy homeostasis.
Yang Z, Huang ZL, Tao YX.
europepmc   +4 more sources

Dual activation of MC3R and MC4R drives weight loss and reduces food intake in male primates with obesity [PDF]

Nature Communications
The melanocortin system plays a central role in regulating hunger and satiety, making it an attractive target for treating metabolic disease. However, the limited clinical success of selective melanocortin-4 receptor (MC4R) agonists has prompted ...
Jillian L. Seiler, Anna C. Impastato, Emma Xiaoyu Zhang, Kade J. Kelley, Thomas L. Bennett, Bradley Studnitzer, Claudia R. Prindle, Benjamin H. Rajewski, Barry A. Badeau, Xinjian Jiang, Russell Potterfield, Jordan Y. Delev, Daniel L. Marks   +12 more
doaj   +2 more sources

Melanocortin‐3 receptors are involved in adaptation to restricted feeding [PDF]

Genes, Brain and Behavior, 2012
The central nervous melanocortin system forms a neural network that maintains energy homeostasis. Actions involving neural melanocortin‐3 receptors (MC3Rs) regulate the expression rhythms in ingestive behaviors and metabolism anticipating nutrient intake.
Begriche, K, Marston, O J, Rossi, J, Burke, L K, McDonald, P, Heisler, L K, Butler, A A   +6 more
openaire   +2 more sources