Results 1 to 10 of about 37,590 (151)

Interaction of central kisspeptin with melanocortin, GABAergic, corticotrophin, and NPY systems on food intake in chickens [PDF]

The Iranian Journal of Veterinary Science and Technology, 2022
Kisspeptin is a key component of reproduction that can directly affect food intake in mammals. There is evidence suggesting that melanocortin, GABA, corticotrophin, and neuropeptide Y (NPY), have a mediatory role in reward; however, how these substances ...
Ahmadreza Kord, Bita Vazir, Morteza Zendedel kheybari, Vahab Babapour, Ahmad Asghari   +4 more
doaj   +1 more source

Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis [PDF]

The FASEB Journal, 2010
ABSTRACT The development of biological therapies has improved management of rheumatoid arthritis. However, costs and unresponsiveness to therapy in a sizeable proportion of patients limit their use, making it imperative to identify new targets for drug development programs.
Hetal B, Patel, Michele, Bombardieri, André L F, Sampaio, Fulvio, D'Acquisto, Mohini, Gray, Paolo, Grieco, Stephen J, Getting, Costantino, Pitzalis, Mauro, Perretti   +8 more
openaire   +4 more sources

Allelic variants of melanocortin 3 receptor gene (MC3R) and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets. [PDF]

PLoS ONE, 2011
INTRODUCTION: The melanocortin system plays an important role in energy homeostasis. Mice genetically deficient in the melanocortin-3 receptor gene have a normal body weight with increased body fat, mild hypophagia compared to wild-type mice.
José L Santos, Rolando De la Cruz, Claus Holst, Katrine Grau, Carolina Naranjo, Alberto Maiz, Arne Astrup, Wim H M Saris, Ian MacDonald, Jean-Michel Oppert, Torben Hansen, Oluf Pedersen, Thorkild I A Sorensen, J Alfredo Martinez, NUGENOB Consortium   +14 more
doaj   +1 more source

Association between Periodontal Disease and Inflammatory Arthritis Reveals Modulatory Functions by Melanocortin Receptor Type 3 [PDF]

The American Journal of Pathology, 2014
Because there is clinical evidence for an association between periodontal disease and rheumatoid arthritis, it is important to develop suitable experimental models to explore pathogenic mechanisms and therapeutic opportunities. The K/BxN serum model of inflammatory arthritis was applied using distinct protocols, and modulation of joint disruption ...
Montero-Melendez, T, Madeira, MFM, Norling, LV, Alsam, A, Curtis, MA, da Silva, TA, Perretti, M   +6 more
openaire   +3 more sources

Next Generation Antiobesity Medications: Setmelanotide, Semaglutide, Tirzepatide and Bimagrumab: What do They Mean for Clinical Practice?

Journal of Obesity & Metabolic Syndrome, 2021
There is a new generation of antiobesity drugs in development or just arriving on the scene. First, setmelanotide has been approved for three of the ultrarare genetic conditions that cause obesity–#8211;pro-opiomelanocortin deficiency, proprotein ...
Donna H. Ryan
doaj   +1 more source

The regulation of food intake by selective stimulation of the type 3 melanocortin receptor (MC3R) [PDF]

Peptides, 2006
High levels of binding sites for melanocortin peptides exist within the arcuate nucleus, and a functional response to melanocortin peptides has been demonstrated in arcuate POMC neurons. Because the MC3R is thought to function as an inhibitory autoreceptor on POMC neurons, we reasoned that peripheral injections of MC3R-specific agonists would act ...
Daniel L, Marks, Victor, Hruby, Gregor, Brookhart, Roger D, Cone   +3 more
openaire   +2 more sources

GLP-1 Receptor Agonist Treatment in Morbid Obesity and Type 2 Diabetes Due to Pathogenic Homozygous Melanocortin-4 Receptor Mutation: A Case Report

Cell Reports Medicine, 2020
Summary: Individuals with obesity due to pathogenic heterozygous melanocortin 4 receptor (MC4R) mutations can be treated efficiently with the glucagon-like peptide-1 receptor agonist (GLP-1 RA) liraglutide.
Eva W. Iepsen, Christian T. Have, Simon Veedfald, Sten Madsbad, Jens J. Holst, Niels Grarup, Oluf Pedersen, Ivan Brandslund, Jens-Christian Holm, Torben Hansen, Signe S. Torekov   +10 more
doaj   +1 more source

Activation of melanocortin type 3 receptor as a molecular mechanism for adrenocorticotropic hormone efficacy in gouty arthritis [PDF]

Arthritis & Rheumatism, 2002
AbstractObjectiveTo test the hypothesis that local activation of melanocortin receptor(s) by adrenocorticotropic hormone (ACTH) could be responsible, at least in part, for its efficacy in human gouty arthritis.MethodsMonosodium urate monohydrate (MSU) crystals were administered into rat knee joints either alone or with ACTH or a selective melanocortin ...
Getting, S, Christian, H, Flower, R, Perretti, M   +3 more
openaire   +2 more sources

Nesfatin-1 induces the phosphorylation levels of cAMP response element-binding protein for intracellular signaling in a neural cell line. [PDF]

PLoS ONE, 2012
Nesfatin-1 is a novel anorexic peptide that reduces the food intake of rodents when administered either intraventricularly or intraperitoneally. However, the molecular mechanism of intracellular signaling via Nesfatin-1 is yet to be resolved.
Emi Ishida, Koshi Hashimoto, Hiroyuki Shimizu, Shuichi Okada, Tetsurou Satoh, Ikuo Kato, Masanobu Yamada, Masatomo Mori   +7 more
doaj   +1 more source

Effect of barodenervation on cardiovascular responses elicited from the hypothalamic arcuate nucleus of the rat. [PDF]

PLoS ONE, 2012
We have previously reported that chemical stimulation of the hypothalamic arcuate nucleus (ARCN) in the rat elicited increases as well as decreases in blood pressure (BP) and sympathetic nerve activity (SNA).
Tetsuya Kawabe, Kazumi Kawabe, Hreday N Sapru   +2 more
doaj   +1 more source