Modulation of Corticotropin-Releasing Hormone Receptor Expression During In Vitro Keratinocyte Differentiation [PDF]
Current Issues in Molecular BiologyCorticotropin-releasing hormone (CRH) and its receptors CRHR1 and CRHR2 are major actors in the stress response and are well established as components of the hypothalamic–pituitary–adrenal (HPA) axis.
Carole-Anne Martins +4 more
doaj +2 more sources
Neural Regeneration Research, 2021 Corticotropin-releasing hormone is a critical component of the hypothalamic–pituitary–adrenal axis, which plays a major role in the body’s immune response to stress.
Piplu Bhuiyan +4 more
doaj +1 more source
The newly developed CRF1-receptor antagonists, NGD 98-2 and NGD 9002, suppress acute stress-induced stimulation of colonic motor function and visceral hypersensitivity in rats. [PDF]
, 2013 Corticotropin releasing factor receptor 1 (CRF1) is the key receptor that mediates stress-related body responses. However to date there are no CRF1 antagonists that have shown clinical efficacy in stress-related diseases.
Czimmer, József +7 more
core +8 more sources
Corticotropin-Releasing Hormone: Biology and Therapeutic Opportunities
Biology, 2022 In 1981, Wylie Vale, Joachim Spiess, Catherine Rivier, and Jean Rivier reported on the characterization of a 41-amino-acid peptide from ovine hypothalamic extracts with high potency and intrinsic activity stimulating the secretion of adrenocorticotropic ...
Alessandra Caruso +2 more
doaj +1 more source
Expression and functional characterization of membrane-integrated mammalian corticotropin releasing factor receptors 1 and 2 in Escherichia coli. [PDF]
PLoS ONE, 2014 Corticotropin-Releasing Factor Receptors (CRFRs) are class B1 G-protein-coupled receptors, which bind peptides of the corticotropin releasing factor family and are key mediators in the stress response.
Roberto Jappelli +7 more
doaj +1 more source
Functional characterization of two corticotropin-releasing hormone receptors in Larimichthys crocea
Frontiers in Marine Science, 2023 In the neuroendocrine system, corticotropin-releasing hormone (CRH) plays an important role in the hypothalamic–pituitary–adrenal/interrenal (HPA/HPI) axis. It exerts its effects by activating CRHRs, which belong to the class B G protein-coupled receptor
Xue Liu +7 more
doaj +1 more source
Communications Biology, 2023 Light exposure can profoundly affect neurological functions and behaviors. Here, we show that short-term exposure to moderate (400 lux) white light during Y-maze test promoted spatial memory retrieval and induced only mild anxiety in mice.
MengJuan Shang +16 more
doaj +1 more source
Вавиловский журнал генетики и селекции, 2021 Stress is an essential part of everyday life. The neuropeptide corticotropin-releasing hormone (CRH, also called CRF and corticoliberin) plays a key role in the integration of neuroendocrine, autonomic and behavioral responses to stress.
E. V. Sukhareva
doaj +1 more source
Mechanism of Anticonvulsant Action of ACTH
Pediatric Neurology Briefs, 2001 The hypothesis that systemic or intraventricular administration of corticotropin (ACTH) acts directly on limbic neurons to modulate corticotropin-releasing hormone (CRH) gene expression, independently of adrenal stimulation, was tested and confirmed in ...
J Gordon Millichap
doaj +1 more source
CRF and urocortin peptides as modulators of energy balance and feeding behavior during stress. [PDF]
, 2014 Early on, corticotropin-releasing factor (CRF), a hallmark brain peptide mediating many components of the stress response, was shown to affect food intake inducing a robust anorexigenic response when injected into the rodent brain.
Stengel, Andreas, Taché, Yvette
core +3 more sources