Results 31 to 40 of about 21,979 (167)
Agonist bias and agonist‐dependent antagonism at corticotrophin releasing factor receptors
Pharmacology Research & Perspectives, 2020 The corticotropin‐releasing factor (CRF) receptors represent potential drug targets for the treatment of anxiety, stress, and other disorders. However, it is not known if endogenous CRF receptor agonists display biased signaling, how effective CRF ...
Zoe Tasma +3 more
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Corticotropin-releasing hormone receptor antagonists [PDF]
European Journal of Endocrinology, 2006 Corticotropin-releasing hormone (CRH), CRH-related peptides, and CRH receptors play major roles in coordinating the behavioral, endocrine, autonomic, and immune responses to stress. The wide influence of the CRH system on physiological processes in both brain and periphery implicates the respective peptides in the pathophysiology of numerous disorders ...
Zoumakis, E. +2 more
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eLife, 2017 The activation mechanism of class B G-protein-coupled receptors (GPCRs) remains largely unknown. To characterize conformational changes induced by peptide hormones, we investigated interactions of the class B corticotropin-releasing factor receptor type ...
Lisa Seidel +4 more
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Characterization of corticotropin receptors on adrenocortical cells. [PDF]
Proceedings of the National Academy of Sciences, 1981 The binding of corticotropin (ACTH) to receptors on isolated rat adrenocortical cells was investigated with the aid of [[125I]ITyr23, Phe2, Nle4]ACTH-(1-38) (125I-ACTH analog) which retained full biological potency and had a specific radioactivity of 1800 +/- 75 Ci/mmol.
D I, Buckley, J, Ramachandran
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Neurobiology of Stress, 2018 Early-life adversity is associated with increased risk for substance abuse in later life, with women more likely to report past and current stress as a mediating factor in their substance use and relapse as compared to men. Preclinical models of neonatal
Gina L. Forster +4 more
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Biomedicines, 2020 Peripheral nociceptors and their synaptic partners utilize neuropeptides for signal transmission. Such communication tunes the excitatory and inhibitory function of nociceptor-based circuits, eventually contributing to pain modulation.
Haiyan Zheng +3 more
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Receptor-mediated immunomodulation by corticotropin-releasing factor
Cellular Immunology, 1991 In both normal and adrenalectomized rats, exogenous corticotropin-releasing factor (CRF) suppresses immune function, and stress-induced immunosuppression can be partially reversed with either CRF antibody or CRF antagonist, suggesting a role for CRF in immunomodulation. We now report binding of CRF to human monocyte-macrophages and T-helper lymphocytes
T, Audhya, R, Jain, C S, Hollander
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Structural and Functional Insights into CRF Peptides and Their Receptors
BiologyCorticotropin-releasing factor or hormone (CRF or CRH) and the urocortins regulate a plethora of physiological functions and are involved in many pathophysiological processes.
Minos-Timotheos Matsoukas +5 more
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Etiopathogenesis of Acne Vulgaris
Van Tıp Dergisi, 2018 Acne vulgaris is a disease of pilosebase unity which is seen generally in adolesans. Clinically lesions may appear chest, back and face and they can be mild comedonal form to cystic acne. The primary lesions of acne is comedon.
Sema Elibüyük Aksaç +3 more
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Applied Biological Chemistry, 2023 Anorexia means loss of appetite and is a state whereby a desire to eat is either reduced or eliminated resulting in reducing or stopping food intake.
Ji Hwan Lee +6 more
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