Results 1 to 10 of about 18,688 (148)

Modulation of Corticotropin-Releasing Hormone Receptor Expression During In Vitro Keratinocyte Differentiation [PDF]

Current Issues in Molecular Biology
Corticotropin-releasing hormone (CRH) and its receptors CRHR1 and CRHR2 are major actors in the stress response and are well established as components of the hypothalamic–pituitary–adrenal (HPA) axis.
Carole-Anne Martins, Sara Lesink, Angéline Roux, Guillaume Collet, Richard Daniellou   +4 more
doaj   +2 more sources

Neuroimmune connections between corticotropin-releasing hormone and mast cells: novel strategies for the treatment of neurodegenerative diseases

Neural Regeneration Research, 2021
Corticotropin-releasing hormone is a critical component of the hypothalamic–pituitary–adrenal axis, which plays a major role in the body’s immune response to stress.
Piplu Bhuiyan, Yi-Wei Wang, Huan-Huan Sha, Hong-Quan Dong, Yan-Ning Qian   +4 more
doaj   +1 more source

Corticotropin-Releasing Hormone: Biology and Therapeutic Opportunities

Biology, 2022
In 1981, Wylie Vale, Joachim Spiess, Catherine Rivier, and Jean Rivier reported on the characterization of a 41-amino-acid peptide from ovine hypothalamic extracts with high potency and intrinsic activity stimulating the secretion of adrenocorticotropic ...
Alessandra Caruso, Alessandra Gaetano, Sergio Scaccianoce   +2 more
doaj   +1 more source

Effects of Growth Hormone Receptor Ablation in Corticotropin-Releasing Hormone Cells [PDF]

International Journal of Molecular Sciences, 2021
Corticotropin-releasing hormone (CRH) cells are the dominant neuronal population responsive to the growth hormone (GH) in the paraventricular nucleus of the hypothalamus (PVH). However, the physiological importance of GH receptor (GHR) signaling in CRH neurons is currently unknown.
Willian O. dos Santos, Daniela O. Gusmao, Frederick Wasinski, Edward O. List, John J. Kopchick, Jose Donato Jr.   +5 more
openaire   +2 more sources

Functional characterization of two corticotropin-releasing hormone receptors in Larimichthys crocea

Frontiers in Marine Science, 2023
In the neuroendocrine system, corticotropin-releasing hormone (CRH) plays an important role in the hypothalamic–pituitary–adrenal/interrenal (HPA/HPI) axis. It exerts its effects by activating CRHRs, which belong to the class B G protein-coupled receptor
Xue Liu, Jiaqian Feng, Zhijing Jiang, Guangbo Zhang, Xiuwen Xu, Jixiu Wang, Jingwen Yang, Tianming Wang   +7 more
doaj   +1 more source

Corticotropin-releasing hormone receptor antagonists [PDF]

European Journal of Endocrinology, 2006
Corticotropin-releasing hormone (CRH), CRH-related peptides, and CRH receptors play major roles in coordinating the behavioral, endocrine, autonomic, and immune responses to stress. The wide influence of the CRH system on physiological processes in both brain and periphery implicates the respective peptides in the pathophysiology of numerous disorders ...
Zoumakis, E., Grammatopoulos, D. K., Chrousos, G. P.   +2 more
openaire   +2 more sources

Interaction between the hypothalamo-pituitary-adrenal and thyroid axes during immobilization stress

Frontiers in Physiology, 2022
The location of corticotropin-releasing hormone receptor 2 (CRH-R2) on thyrotropes within the avian anterior pituitary (APit) and its activation by different stressors indicate a possible communication between hypothalamo-pituitary-adrenal (HPA) and ...
Hakeem J. Kadhim, Wayne J. Kuenzel
doaj   +1 more source

Moderate white light exposure enhanced spatial memory retrieval by activating a central amygdala-involved circuit in mice

Communications Biology, 2023
Light exposure can profoundly affect neurological functions and behaviors. Here, we show that short-term exposure to moderate (400 lux) white light during Y-maze test promoted spatial memory retrieval and induced only mild anxiety in mice.
MengJuan Shang, MeiLun Shen, RuoTong Xu, JingYu Du, JiMeng Zhang, Ding OuYang, JunZe Du, JunFeng Hu, ZhiChuan Sun, BingXia Wang, Qian Han, Yang Hu, YiHong Liu, Yun Guan, Jing Li, GuoZhen Guo, JunLing Xing   +16 more
doaj   +1 more source

Chia seeds oil ameliorate chronic immobilization stress-induced neurodisturbance in rat brains via activation of the antioxidant/anti-inflammatory/antiapoptotic signaling pathways

Scientific Reports, 2023
Chronic immobilization stress plays a key role in several neuropsychiatric disorders. This investigation assessed the possible ameliorative effect of chia seed oil (CSO) against the neurodisturbance-induced in rats by chronic immobilization.
Norhan E. Khalifa, Ahmed E. Noreldin, Asmaa F. Khafaga, Mohamed El-Beskawy, Eman Khalifa, Ali H. El-Far, Abdel-Hasseb A. Fayed, Abdeldayem Zakaria   +7 more
doaj   +1 more source

Proopiomelanocortin, corticotropin releasing hormone and corticotropin releasing hormone receptor genes are expressed in human skin [PDF]

FEBS Letters, 1995
Evidence is provided that human skin, the largest body organ exposed to multiple stressors, expresses proopiomelanocortin (POMC), corticotropin releasing hormone (CRH) and CRH‐receptor (CRHR) genes in vivo. In vitro studies show that POMC and CRHR mRNAs are transcribed in melanocytes, cells derived from the neural crest, and in keratinocytes, cells ...
Slominski, A., Ermak, G., Hwang, J., Chakraborty, A., Mazurkiewicz, J.E., Mihm, M.   +5 more
openaire   +2 more sources