Results 21 to 30 of about 19,155 (223)
Urocortins in the mammalian endocrine system
Acta Veterinaria Scandinavica, 2019 Urocortins (Ucns), peptides belonging to the corticotropin-releasing hormone (CRH) family, are classified into Ucn1, Ucn2, and Ucn3. They are involved in regulating several body functions by binding to two G protein-coupled receptors: receptor type 1 ...
Caterina Squillacioti +3 more
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Biomedicines, 2023 The aim of the present study was to determine the effects of alcohol intoxication and withdrawal on hypothalamic neurohormones such as corticotropin-releasing factor (CRF) and arginine vasopressin (AVP), and extrahypothalamic neurotransmitters such as ...
Balázs Simon +9 more
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Frontiers in Molecular Neuroscience, 2018 Based on pharmacological studies, corticotropin-releasing hormone (CRH) and its receptors play a leading role in the inhibition of the hypothalamic–pituitary–gonadal (HPG) axis during acute stress.
Androniki Raftogianni +11 more
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Frontiers in Neuroscience, 2021 The bed nuclei of the stria terminalis (BST) is a limbic region in the extended amygdala that is heavily implicated in anxiety processing and hypothalamic-adrenal-pituitary (HPA) axis activation.
Claire Emily Young +3 more
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Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors [PDF]
Molecular Cell, 2020 Corticotropin-releasing factor (CRF) and the three related peptides urocortins 1-3 (UCN1-UCN3) are endocrine hormones that control the stress responses by activating CRF1R and CRF2R, two members of class B G-protein-coupled receptors (GPCRs). Here, we present two cryoelectron microscopy (cryo-EM) structures of UCN1-bound CRF1R and CRF2R with the ...
Shanshan, Ma +15 more
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Pharmaceuticals, 2022 Mast cell (MC) plays a central role in intestinal permeability; however, few MC-targeting drugs are currently available for protection of the intestinal barrier in clinical practice.
Yueshan Sun +8 more
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Biomedicines, 2023 Sepsis is associated with dysregulated cortisol secretion, leading to abnormal levels of cortisol in the blood. In the early stages of the condition, cortisol levels are typically elevated due to increased secretion from the adrenal glands.
Ioannis Ilias +6 more
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On the role of corticotropin-releasing hormone receptors in anxiety and depression
Dialogues in Clinical Neuroscience, 2002 On the basis of extensive basic and clinical studies, corticotropin-releasing hormone (CRH) and its related family members are considered to play a pivotal role in stress-related disorders, such as anxiety and depression. CRH is regarded as the principal mediator in the brain of the stress response, as it mediates neuroendocrine, autonomic, and ...
Reul, Johannes M H M, Holsboer, Florian
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Brain corticotropin releasing hormone and stress reactivity
Интегративная физиология, 2021 The hypothalamic-pituitary-adrenocortical axis is one of the main components of stress adaptation. Corticotropin-releasing hormone (CRH) coming from the nucleus paraventricularis hypothalami (PVN) is the canonical central regulator of the axis.
Krisztina Bánrévi +6 more
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Corticotropin-Releasing Hormone Family and Their Receptors in the Cardiovascular System
Circulation Journal, 2019 The identification of corticotropin-releasing hormone (CRH) has led to the discovery of a growing family of ligands and receptors. CRH receptor 1 (CRHR1) and CRHR2 are mammalian G-protein coupled receptors (GPCRs) with high affinity for CRH and the CRH family of peptides.
Takefuji, Mikito, Murohara, Toyoaki
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