Results 31 to 40 of about 19,155 (223)
Regulation of gonadotropins by corticotropin-releasing factor and urocortin
Frontiers in Endocrinology, 2013 While stress activates the hypothalamic-pituitary-adrenal (HPA) axis, it suppresses the hypothalamic-pituitary-gonadal (HPG) axis. Corticotropin-releasing factor (CRF) is a major regulatory peptide in the HPA axis during stress.
Kazunori eKageyama
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Insights into mechanisms of corticotropin‐releasing hormone receptor signal transduction [PDF]
British Journal of Pharmacology, 2012 During evolution, mammals have developed remarkably similar molecular mechanisms to respond to external challenges and maintain survival. Critical regulators of these mechanisms are the family of ‘stress’‐peptides that consists of the corticotropin‐releasing hormone (CRH) and urocortins (Ucns).
openaire +2 more sources
A Polymorphism of the Corticotropin-Releasing Hormone Receptor 2 (CRHR2) and Preterm Birth [PDF]
Disease Markers, 2010 Our aim was to investigate whether a genetic variation in the corticotropin-releasing hormone receptor 2 gene might be associated with preterm birth. In this case-control study we evaluated the G/A polymorphism (rs2267717) in intron 2 of the corticotropin-releasing hormone receptor 2 gene in one hundred women with preterm birth and one hundred healthy ...
Schmid, Maximilian +5 more
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Advanced Science, EarlyView.Early life adversity triggers persistent social subordination and brain‐wide molecular dysregulation. Pharmacological inhibition of the stress‐mediator FKBP51 during the adversity period prevents these long‐term deficits and restores normative social hierarchy.
Joeri Bordes +15 more
wiley +1 more source
Frontiers in Endocrinology, 2022 Hypothalamus-pituitary-adrenal (HPA) axis plays critical roles in stress responses under challenging conditions such as hypoxia, via regulating gene expression and integrating activities of hypothalamus-pituitary-targets cells.
Tong Ying Wang +23 more
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Corticotropin-releasing hormone receptor-1 in human endometrial cancer
Oncology Reports, 2006 We have previously shown that corticotrophin-releasing hormone (CRH) inhibits the proliferation of Ishikawa (IK) human endometrial carcinoma cell line through the activation of CRH-R1 receptors. Here, we have further investigated the role of CRH and its type-1 receptor in the control of IK cell function, and we carried out a pilot study in tumor ...
GRAZIANI, GRAZIA +8 more
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Corticotropin releasing hormone receptor 2 exacerbates chronic cardiac dysfunction [PDF]
Journal of Experimental Medicine, 2017 Heart failure occurs when the heart is unable to effectively pump blood and maintain tissue perfusion. Despite numerous therapeutic advancements over previous decades, the prognosis of patients with chronic heart failure remains poor, emphasizing the need to identify additional pathophysiological factors.
Takuma Tsuda +15 more
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Hypothalamic Control of Liver Health and Disease: From Circuits to Pathophysiology and Therapies
Advanced Science, EarlyView.This review delineates the hypothalamic circuits that control liver homeostasis via autonomic and neuroendocrine pathways. Dysregulation of this hypothalamus–liver axis drives disease progression across a spectrum including steatotic liver disease, liver inflammation and injury, fibrosis, cirrhosis, and hepatocellular carcinoma.
Qin Tang +7 more
wiley +1 more source
Cells, 2020 No organ in the body is impervious to the effects of stress, and a coordinated response from all organs is essential to deal with stressors. A dysregulated stress response that fails to bring systems back to homeostasis leads to compromised function and ...
Lahari Vuppaladhadiam +3 more
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Applied Biological Chemistry, 2023 Anorexia means loss of appetite and is a state whereby a desire to eat is either reduced or eliminated resulting in reducing or stopping food intake.
Ji Hwan Lee +6 more
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