Results 31 to 40 of about 18,708 (168)
Physiological Roles of Corticotropin-Releasing Hormone Receptor Type 2.
Endocrine Journal, 2001 Recent investigations of the physiological roles of CRH-R2 are reviewed and summarized in Fig. 5. VMH CRH-R2 is more important than CRH-R1 in mediating anorexic effect of CRH or urocortin (UCN) and stress-induced reduction of food intake. CRH-R2 mediates a central anxiolytic response, opposing the anxiogenic effect of CRH mediated by CRH-R1 ...
K, Hashimoto +3 more
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Frontiers in Endocrinology, 2022 Hypothalamus-pituitary-adrenal (HPA) axis plays critical roles in stress responses under challenging conditions such as hypoxia, via regulating gene expression and integrating activities of hypothalamus-pituitary-targets cells.
Tong Ying Wang +23 more
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Addiction and corticotropin‐releasing hormone type 1 receptor antagonist medications
Annals of the New York Academy of Sciences, 2013 Derangements in corticotropin‐releasing hormone (CRH) through its type 1 receptor (CRHR1) have been identified in many pathologic conditions. Preclinical models of addiction find that small‐molecule antagonists of CRHR1 can limit induction, maintenance, and relapse to drugs of abuse.
Contoreggi, Carlo +2 more
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Cells, 2020 No organ in the body is impervious to the effects of stress, and a coordinated response from all organs is essential to deal with stressors. A dysregulated stress response that fails to bring systems back to homeostasis leads to compromised function and ...
Lahari Vuppaladhadiam +3 more
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Applied Biological Chemistry, 2023 Anorexia means loss of appetite and is a state whereby a desire to eat is either reduced or eliminated resulting in reducing or stopping food intake.
Ji Hwan Lee +6 more
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Insights into mechanisms of corticotropin‐releasing hormone receptor signal transduction [PDF]
British Journal of Pharmacology, 2012 During evolution, mammals have developed remarkably similar molecular mechanisms to respond to external challenges and maintain survival. Critical regulators of these mechanisms are the family of ‘stress’‐peptides that consists of the corticotropin‐releasing hormone (CRH) and urocortins (Ucns).
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Frontiers in Physiology, 2019 Urotensin I (UI), a fish corticotropin-releasing hormone (CRH) like peptide, has been found throughout vertebrate species that has great effects on adaptive physiology comprising stress-related responses, and osmotic regulation by binding with CRH type I
Hong Zhou +8 more
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Psychological Stress Increases Hippocampal Mineralocorticoid Receptor Levels: Involvement of Corticotropin-Releasing Hormone [PDF]
The Journal of Neuroscience, 2001 We investigated whether acute stressors regulate functional properties of the hippocampal mineralocorticoid receptor (MR), which acts inhibitory on hypothalamic-pituitary-adrenocortical activity. Exposure of rats to forced swimming or novelty evoked a significant rise in density of MR immunoreactivity in all hippocampal subfields after 24 hr, whereas ...
Gesing, A +5 more
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The reciprocal regulation of stress hormones and GABAA receptors
Frontiers in Cellular Neuroscience, 2012 Stress-derived steroid hormones regulate the expression and function of GABAA receptors (GABAARs). Changes in GABAAR subunit expression have been demonstrated under conditions of altered steroid hormone levels, such as stress, as well as following ...
Istvan eMody, Jamie eMaguire
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A novel role of peripheral corticotropin-releasing hormone (CRH) on dermal fibroblasts. [PDF]
PLoS ONE, 2011 Corticotropin-releasing hormone, or factor, (CRH or CRF) exerts important biological effects in multiple peripheral tissues via paracrine/autocrine actions.
Olga Rassouli +8 more
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