Results 41 to 50 of about 19,155 (223)

Physiological Roles of Corticotropin-Releasing Hormone Receptor Type 2.

Endocrine Journal, 2001
Recent investigations of the physiological roles of CRH-R2 are reviewed and summarized in Fig. 5. VMH CRH-R2 is more important than CRH-R1 in mediating anorexic effect of CRH or urocortin (UCN) and stress-induced reduction of food intake. CRH-R2 mediates a central anxiolytic response, opposing the anxiogenic effect of CRH mediated by CRH-R1 ...
HASHIMOTO, KOZO, MAKINO, SHINYA, ASABA, KOICHI, NISHIYAMA, MITSURU   +3 more
openaire   +3 more sources

POEMS Syndrome: 2026 Update on Diagnosis, Risk‐Stratification, and Management

American Journal of Hematology, EarlyView.
ABSTRACT Disease Overview POEMS syndrome is a life‐threatening syndrome due to an underlying plasma cell neoplasm. The major criteria for the syndrome are polyneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and the presence of Castleman disease.
Angela Dispenzieri
wiley   +1 more source

Dynamic Expression and Regulation of Urotensin I and Corticotropin-Releasing Hormone Receptors in Ovary of Olive Flounder Paralichthys olivaceus

Frontiers in Physiology, 2019
Urotensin I (UI), a fish corticotropin-releasing hormone (CRH) like peptide, has been found throughout vertebrate species that has great effects on adaptive physiology comprising stress-related responses, and osmotic regulation by binding with CRH type I
Hong Zhou, Hong Zhou, Chunmei Ge, Chunmei Ge, Aqin Chen, Aqin Chen, Weiqun Lu, Weiqun Lu, Weiqun Lu   +8 more
doaj   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

The reciprocal regulation of stress hormones and GABAA receptors

Frontiers in Cellular Neuroscience, 2012
Stress-derived steroid hormones regulate the expression and function of GABAA receptors (GABAARs). Changes in GABAAR subunit expression have been demonstrated under conditions of altered steroid hormone levels, such as stress, as well as following ...
Istvan eMody, Jamie eMaguire
doaj   +1 more source

Repeated exposure to kairomone-containing coffee odor improves abnormal olfactory behaviors in heterozygous oxytocin receptor knock-in mice

Frontiers in Behavioral Neuroscience, 2023
The oxytocin receptor (OXTR) knockout mouse is a model of autism spectrum disorder, characterized by abnormalities in social and olfactory behaviors and learning. Previously, we demonstrated that OXTR plays a crucial role in regulating aversive olfactory
Kazumi Osada, Riyuki Kujirai, Akira Hosono, Masato Tsuda, Motoko Ohata, Tohru Ohta, Katsuhiko Nishimori   +6 more
doaj   +1 more source

Addiction and corticotropin‐releasing hormone type 1 receptor antagonist medications

Annals of the New York Academy of Sciences, 2013
Derangements in corticotropin‐releasing hormone (CRH) through its type 1 receptor (CRHR1) have been identified in many pathologic conditions. Preclinical models of addiction find that small‐molecule antagonists of CRHR1 can limit induction, maintenance, and relapse to drugs of abuse.
Contoreggi, Carlo, Lee, Mary R., Chrousos, George   +2 more
openaire   +3 more sources

Cardioprotective and Vasoprotective Effects of Corticotropin-Releasing Hormone and Urocortins: Receptors and Signaling

Journal of Cardiovascular Pharmacology and Therapeutics, 2021
Despite the recent progress in research and therapy, cardiovascular diseases are still the most common cause of death worldwide, thus new approaches are still needed. The aim of this review is to highlight the cardioprotective potential of urocortins and corticotropin-releasing hormone (CRH) and their signaling.
Sergey V. Popov, Ekaterina S. Prokudina, Alexander V. Mukhomedzyanov, Natalia V. Naryzhnaya, Huijie Ma, Jitka M. Zurmanova, Peter F. M. van der Ven, Leonid N. Maslov   +7 more
openaire   +2 more sources

The diagnostic value of the circadian rhythm gene KLF10 in anxiety‐depressive disorders and its neuroimmune regulatory mechanisms

Animal Models and Experimental Medicine, EarlyView.
This graphical abstract illustrates the protective role and molecular mechanism of the circadian rhythm‐related gene KLF10, identified as a diagnostic biomarker and therapeutic target in anxiety‐depressive disorder. Model establishment and phenotypes: An anxiety‐depression model was successfully established by chronic restraint stress combined with ...
Anlan Liu, Weifeng Guo, Jianxiang Li, Tiange Zhang, Dan Xu   +4 more
wiley   +1 more source

A novel role of peripheral corticotropin-releasing hormone (CRH) on dermal fibroblasts. [PDF]

PLoS ONE, 2011
Corticotropin-releasing hormone, or factor, (CRH or CRF) exerts important biological effects in multiple peripheral tissues via paracrine/autocrine actions.
Olga Rassouli, George Liapakis, Iakovos Lazaridis, George Sakellaris, Kostas Gkountelias, Achille Gravanis, Andrew N Margioris, Katia P Karalis, Maria Venihaki   +8 more
doaj   +1 more source