Results 41 to 50 of about 18,708 (168)

Repeated exposure to kairomone-containing coffee odor improves abnormal olfactory behaviors in heterozygous oxytocin receptor knock-in mice

Frontiers in Behavioral Neuroscience, 2023
The oxytocin receptor (OXTR) knockout mouse is a model of autism spectrum disorder, characterized by abnormalities in social and olfactory behaviors and learning. Previously, we demonstrated that OXTR plays a crucial role in regulating aversive olfactory
Kazumi Osada, Riyuki Kujirai, Akira Hosono, Masato Tsuda, Motoko Ohata, Tohru Ohta, Katsuhiko Nishimori   +6 more
doaj   +1 more source

Noise stress changes mRNA expressions of corticotropin-releasing hormone, its receptors in amygdala, and anxiety-related behaviors

Noise and Health, 2015
Noise is a psychological, environmental stressor that activates limbic sites in the brain. Limbic sites such as the amygdala and the amygdaloid corticotropin-releasing hormone (CRH) system play an important role in integrating stress response.
Evren Eraslan, Ibrahim Akyazi, Elif Ergül-Ekiz, Erdal Matur   +3 more
doaj   +1 more source

The expression and possible role of corticotropin-releasing hormone family peptides and their corresponding receptors in gynaecological malignancies and premalignant conditions: a systematic review

Menopause Review, 2023
The aim of this systematic review is to investigate the impact of corticotropin-releasing hormone (CRH) family peptides and their corresponding receptors on human physiology and disease onset, with a specific focus on gynaecological malignancies such as ...
Angelos Dimas, Chrysoula Margioula-Siarkou, Anastasia Politi, Alexandros Sotiriadis, Alexios Papanikolaou, Konstantinos Dinas, Stamatios Petousis   +6 more
doaj   +1 more source

Structural and Functional Insights into CRF Peptides and Their Receptors

Biology
Corticotropin-releasing factor or hormone (CRF or CRH) and the urocortins regulate a plethora of physiological functions and are involved in many pathophysiological processes.
Minos-Timotheos Matsoukas, Vasilis Panagiotopoulos, Vlasios Karageorgos, George P. Chrousos, Maria Venihaki, George Liapakis   +5 more
doaj   +1 more source

Role of the nuclear receptor subfamily 4a in mast cells in the development of irritable bowel syndrome

Computational and Structural Biotechnology Journal, 2022
The activation of mast cells (MCs) and mediator release are closely related to the pathophysiology of irritable bowel syndrome (IBS). However, the exact underlying mechanisms are still not completely understood.
Ruidi Li, Shuhui Chen, Xinpei Gu, Shuhong An, Zhaojin Wang   +4 more
doaj   +1 more source

Neuro-allergology: Mast cell–nerve cross-talk

Allergology International, 2022
Mast cells (MCs) are derived from hematopoietic stem cells in the bone marrow, and their maturation is regulated by the tissue environment, such as the skin, lung and gut, leading to host defense.
Shota Toyoshima, Yoshimichi Okayama
doaj   +1 more source

Molecular Imaging Targeting Corticotropin-releasing Hormone Receptor for Corticotropinoma: A Changing Paradigm

The Journal of Clinical Endocrinology & Metabolism, 2020
Abstract Background Corticotrophin-releasing hormone (CRH) is the major regulator of adrenocorticotrophic hormone (ACTH) secretion from the anterior pituitary and acts via CRH-1 receptors (CRH-1R).
Rama Walia, Rahul Gupta, Anil Bhansali, Rosario Pivonello, Rajender Kumar, Harmandeep Singh, Chirag Ahuja, Rajesh Chhabra, Apinderpreet Singh, Sivashanmugam Dhandapani, Sushant Sahoo, Nivedita Rana, Rakhee Vatsa, Pinaki Dutta, Sanjay Kumar Bhadada, Naresh Sachdeva, B R Mittal, Uma Nahar, Jaya Shukla   +18 more
openaire   +3 more sources

Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells

Annals of Medicine
Background Stress-related hair loss is on the rise, largely due to escalating levels of stress-related corticotropin-releasing hormone (CRH) through poorly defined mechanisms.
Wenzi Liang, Xiuwen Chen, Na Ni, Chutong Zhuang, Zhiying Yu, Ziqing Xu, Yingshi Li, Changmin Lin, Keng Huang   +8 more
doaj   +1 more source

Pharmacogenetics of antidepressants

Frontiers in Pharmacology, 2011
Up to 60% of depressed patients do not respond completely to antidepressants (AD) and up to 30% do not respond at all. Genetic factors contribute for about 50% of the AD response. During the recent years the possible influence of a set of candidate genes
Concetta eCrisafulli, Chiara eFabbri, Stefano ePorcelli, Antonio eDrago, Edoardo eSpina, Diana eDe Ronchi, Alessandro eSerretti   +6 more
doaj   +1 more source

Corticotropin-Releasing Hormone Receptor 2 Gene Variants in Irritable Bowel Syndrome

PLOS ONE, 2016
Corticotropin-releasing hormone (CRH) plays an important role in the pathophysiology of irritable bowel syndrome (IBS) and regulates the stress response through two CRH receptors (R1 and R2). Previously, we reported that a CRHR1 gene polymorphism (rs110402, rs242924, and rs7209436) and haplotypes were associated with IBS.
Hazuki Komuro, Naoko Sato, Ayaka Sasaki, Naoki Suzuki, Michiko Kano, Yukari Tanaka, Yumi Yamaguchi-Kabata, Motoyori Kanazawa, Hitoshi Warita, Masashi Aoki, Shin Fukudo   +10 more
openaire   +4 more sources