Results 61 to 70 of about 19,155 (223)

Epilepsy‐associated SCN2A‐L1342P mutation drives network hyperexcitability and widespread transcriptomic changes in human cortical organoids

Epilepsia, EarlyView.
Abstract Objective SCN2A pathogenic mutations, such as the recurrent heterozygous Nav1.2‐L1342P, are monogenic causes of epilepsy. In this human‐induced pluripotent stem cell–derived model system, we aim to investigate the molecular and cellular mechanisms underlying SCN2A‐L1342P‐associated pathology. Methods Using a human male induced pluripotent stem
Maria I. Olivero‐Acosta, Morgan Robinson, Zhefu Que, Zaiyang Zhang, Karen V. Salazar‐Salazar, Hope Elizabeth Harlow, Vinayak Shankar, Seoyeon Hong, Muhan Wang, Conrad M. Otterbacher, Hina Kadono, Manasi Halurkar, Harish Kothandaraman, Nadia Atallah Lanman, Trang Nguyen, Kyle Wettschurack, Benjamin Zirkle, Layan Yunis, Ningren Cui, Xiaoling Chen, Jingliang Zhang, Jiaxiang Wu, William C. Skarnes, Chongli Yuan, Feng Guo, Megan Abbott, Yang Yang   +26 more
wiley   +1 more source

Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells

Annals of Medicine
Background Stress-related hair loss is on the rise, largely due to escalating levels of stress-related corticotropin-releasing hormone (CRH) through poorly defined mechanisms.
Wenzi Liang, Xiuwen Chen, Na Ni, Chutong Zhuang, Zhiying Yu, Ziqing Xu, Yingshi Li, Changmin Lin, Keng Huang   +8 more
doaj   +1 more source

Pharmacogenetics of antidepressants

Frontiers in Pharmacology, 2011
Up to 60% of depressed patients do not respond completely to antidepressants (AD) and up to 30% do not respond at all. Genetic factors contribute for about 50% of the AD response. During the recent years the possible influence of a set of candidate genes
Concetta eCrisafulli, Chiara eFabbri, Stefano ePorcelli, Antonio eDrago, Edoardo eSpina, Diana eDe Ronchi, Alessandro eSerretti   +6 more
doaj   +1 more source

New insights into epileptic spasm generation and treatment from the TTX animal model

Epilepsia Open, EarlyView.
Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann, Carlos J. Ballester‐Rosado, Chih‐Hong Lee   +2 more
wiley   +1 more source

Expression of urocortin and corticotropin-releasing hormone receptors in the bovine adrenal gland

General and Comparative Endocrinology, 2011
Urocortin (UCN), a 40 amino acid peptide, is a corticotrophin-releasing hormone (CRH)-related peptide. The biological actions of CRH family peptides are mediated via two types of G protein-coupled receptors, CRH type 1 receptor (CRHR1) and CRH type 2 receptor (CRHR2).
SQUILLACIOTI, CATERINA, DE LUCA, ADRIANA, LIGUORI, GIOVANNA, S. PAINO, MIRABELLA, NICOLA   +4 more
openaire   +3 more sources

Prenatal betamethasone–postnatal N‐methyl‐D‐aspartic acid model of spasms: Update on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Infantile epilepsy spasms syndrome (IESS), formerly known as infantile spasms or West Syndrome, is a severe epilepsy syndrome affecting about 3 in 10,000 newborns in the United States. Characterized by clusters of epileptic spasms, interictal hypsarrhythmia, and developmental delays, IESS has diverse causes, including structural‐metabolic ...
Kayla Vieira, Antonia Schonwald, Chian‐Ru Chern, Kamya Shah, Jana Velíšková, Libor Velíšek   +5 more
wiley   +1 more source

Immune Aspects and Myometrial Actions of Progesterone and CRH in Labor

Clinical and Developmental Immunology, 2012
Progesterone and corticotropin-releasing hormone (CRH) have a critical role in pregnancy and labor, as changes related to these hormones are crucial for the transition from myometrial quiescence to contractility.
Nikolaos Vrachnis, Fotodotis M. Malamas, Stavros Sifakis, Panayiotis Tsikouras, Zoe Iliodromiti   +4 more
doaj   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Maternal and infant gut microbiome

iMeta, EarlyView.
The maternal–infant continuum involves critical windows of host–microbiota co‐adaptation. Preconception, maternal and paternal microbiomes modulate immunity and reproduction. During pregnancy, a gut–placenta axis emerges, where microbial metabolites influence fetal growth or contribute to complications like gestational diabetes mellitus (GDM ...
Huidi Wang, Felicia Tin, Hui Chen, Fuxin Jiao, Min Wu, Shanshan Sun, Lisha Lin, Die Li, Huimin Zheng, Zhenxin Niu, Mengyao Lan, Bahtiyar Yilmaz, Johan G. Eriksson, Mengjia Wang, Andrew Macpherson, Jose C. Clemente, Jia Xu, Ri‐hua Xie, Xiaojiao Zheng, Tao Zhou, Jinfeng Wang, Wei Shen, Bing Huang, Xia Chen, Hai Li, Yan He   +25 more
wiley   +1 more source

Offspring Global DNA Methylation is not Affected by Parental Developmental Stress Experience in a Passerine Species

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT Rapid phenotypic change may be mediated by intergenerational transmission of early developmental experiences. In birds, exposure to glucocorticoids during early development can alter global DNA methylation and gene expression. However, DNA methylation is labile, and it is currently unclear whether the impacts of stress suffered during juvenile
Anna Miltiadous, Harrison J. F. Eyck, Ondi L. Crino, Lee A. Rollins, Damien Callahan, Katherine L. Buchanan   +5 more
wiley   +1 more source