Results 81 to 90 of about 19,155 (223)

Hypothesis of the neuroendocrine cortisol pathway gene role in the comorbidity of depression, type 2 diabetes, and metabolic syndrome

The Application of Clinical Genetics, 2014
Claudia Gragnoli1,21Center for Biotechnology and Department of Biology, College of Science and Technology, Temple University, Philadelphia, PA, USA; 2Molecular Biology Laboratory, Bios Biotech Multi-Diagnostic Health Center, Rome, ItalyAbstract ...
Gragnoli C
doaj  

Sex‐Specific Involvement of Gut Microbiota in Behavioral and Endocrine Responses to Chronic Predator Odor in Brandt's Voles

Integrative Zoology, EarlyView.
18 days of predator odor exposure altered gut microbiota, increased anxiety‐like behaviors, and elevated hypothalamic–pituitary–adrenal axis activity in Brandt's voles, with males showing behavioral habituation and females remaining sensitive. Cecal microbiota transplantation experiments confirmed that only female recipients of microbiota from predator‐
Chen Gu, Ruiping Xu, Baofa Yin, Ruiyong Wu, Youheng Wei, Dehua Wang, Wanhong Wei   +6 more
wiley   +1 more source

Expression of urocortin and corticotropin-releasing hormone receptors in the horse thyroid gland

Cell and Tissue Research, 2012
Urocortin (UCN) is a 40-amino-acid peptide and a member of the corticotropin-releasing hormone (CRH) family, which includes CRH, urotensin I, sauvagine, UCN2 and UCN3. The biological actions of CRH family peptides are mediated via two types of G-protein-coupled receptors, namely CRH type 1 receptor (CRHR1) and CRH type 2 receptor (CRHR2).
SQUILLACIOTI, CATERINA, DE LUCA, ADRIANA, ALI', SABRINA, Paino, S, LIGUORI, GIOVANNA, MIRABELLA, NICOLA   +5 more
openaire   +3 more sources

Amylin analogues as a novel perspective in anti‐obesity therapy

British Journal of Pharmacology, EarlyView.
Abstract Public health systems face a major challenge because of the worldwide obesity epidemic. The number of obese individuals has increased dramatically and, even in Switzerland which may be considered a relatively “lean” country, the numbers are alarmingly high and have reached almost 50% of the adult population.
Thomas A. Lutz
wiley   +1 more source

Atrial natriuretic peptide counteracts aldosterone secretion by preventing acute angiotensin II‐induced cAMP signalling

British Journal of Pharmacology, EarlyView.
Background and Purpose Aldosterone plays a key role in blood pressure and volume regulation. Enhanced aldosterone secretion contributes to cardiovascular and renal diseases. Therefore, inhibitors of aldosterone receptors and synthase are essential drugs for the treatment of hypertension and heart failure.
Sanika Mohagaonkar, Egor B. Skryabin, Bettina M. Buchholz, Michaela Kuhn, Celso E. Gomez‐Sanchez, Stepan Gambaryan, Viacheslav O. Nikolaev   +6 more
wiley   +1 more source

Gut microbiota as a novel therapeutic target for eating disorders and obesity

British Journal of Pharmacology, EarlyView.
The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė, Victor Mathis, Emmanuel Darcq, Aurelijus Burokas, Elena Martín‐García, Rafael Maldonado   +5 more
wiley   +1 more source

Role of the hypothalamic pituitary adrenal axis in the control of the response to stress and infection

Brazilian Journal of Medical and Biological Research, 2000
The release of adrenocorticotropin (ACTH) from the corticotrophs is controlled principally by vasopressin and corticotropin-releasing hormone (CRH). Oxytocin may augment the release of ACTH under certain conditions, whereas atrial natriuretic peptide ...
McCann S.M., Antunes-Rodrigues J., Franci C.R., Anselmo-Franci J.A., Karanth S., Rettori V.   +5 more
doaj  

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

Skin Corticotropin-Releasing Hormone Receptor Expression in Psoriasis [PDF]

Journal of Investigative Dermatology, 2007
Tagen, Michael, Stiles, Linsey, Kalogeromitros, Demetrios, Gregoriou, Stamatios, Kempuraj, Duraisamy, Makris, Michael, Donelan, Jill, Vasiadi, Magdalini, Staurianeas, Nikolaos G., Theoharides, Theoharis C.   +9 more
openaire   +3 more sources

Hypercortisolism: Causes, Consequences and Clinical Significance – A Review of Pathophysiology

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Hypercortisolism or Cushing syndrome is a heterogeneous clinical spectrum caused by chronic glucocorticoid excess, ranging from exogenous Cushing syndrome to rare endogenous aetiologies and the increasingly recognised entity of mild autonomous cortisol secretion (MACS). Physiological cortisol production is tightly regulated by the hypothalamic–
Mohamed Eldib, Francisco Emilio Fierro, Maria Ortega Abad, Ricardo Correa   +3 more
wiley   +1 more source