Results 1 to 10 of about 29,732 (168)

Augmented Cocaine Seeking in Response to Stress or CRF Delivered into the Ventral Tegmental Area Following Long-Access Self-Administration Is Mediated by CRF Receptor Type 1 But Not CRF Receptor Type 2 [PDF]

The Journal of Neuroscience, 2011
Stressful events are determinants of relapse in recovering cocaine addicts. Excessive cocaine use may increase susceptibility to stressor-induced relapse through alterations in brain corticotropin-releasing factor (CRF) regulation of neurocircuitry involved in drug seeking. We previously reported that the reinstatement of cocaine seeking by a stressor (
Blacktop, Jordan M., Seubert, Chad, Baker, David A., Ferda, Nathan, Lee, Geng, Graf, Evan N., Mantsch, John R.   +6 more
openaire   +5 more sources

An anxiolytic role for CRF receptor type 1 in the globus pallidus. [PDF]

J Neurosci, 2011
Corticotropin-releasing factor receptor type 1 (CRFR1) plays a major role in the regulation of neuroendocrine and behavioral responses to stress and is considered a key mediator of anxiety behavior. The globus pallidus external (GPe), a main relay center within the basal ganglia that is primarily associated with motor and associative functions, is one ...
Sztainberg Y, Kuperman Y, Justice N, Chen A.   +3 more
europepmc   +4 more sources

Long-lasting mechanical hypersensitivity and CRF receptor type-1 neuron activation in the BNST following adolescent ethanol exposure. [PDF]

Alcohol Clin Exp Res (Hoboken), 2023
AbstractBackgroundAdolescent alcohol use can produce long‐lasting alterations in brain function, potentially leading to adverse health outcomes in adulthood. Emerging evidence suggests that chronic alcohol use can increase pain sensitivity or exacerbate existing pain conditions, but the potential neural mechanisms underlying these effects require ...
Bertagna NB, Wilson L, Bailey CK, Cruz FC, Albrechet-Souza L, Wills TA.   +5 more
europepmc   +3 more sources

Pharmacological Characterization of the Novel CRF1 Receptor Antagonist, Thiazolo[4,5-d] Pyrimidine Analog, M43 [PDF]

Biomolecules
The corticotropin-releasing factor (CRF) and its type 1 receptor (CRF1R) play a key role in the regulation of the hypothalamic–pituitary–adrenal (HPA) axis.
Spyridon Marios Giatro, George Komontachakis, Aikaterini Kalantidou, Nastazia Lesgidou, Vlasios Karageorgos, Mohamed Teleb, Md Rabiul Islam, Thomas Mavromoustakos, Hesham Fahmy, Maria Venihaki, Minos-Timotheos Matsoukas, George Liapakis   +11 more
doaj   +2 more sources

Mild chronic stress promotes female fertility via the ovarian CRF receptor [PDF]

Cell Communication and Signaling
Background In many species, including human, stress is accompanied by disruption of reproductive functions. The endocrine stress-response is activated and regulated by members of the corticotropin releasing factor (CRF) protein family. Stress stimuli may
Eran Gershon, Orna Issler, Mariana Schroeder, Yael Kuperman, Nava Nevo, Shlomi Lazar, Michal Elbaz, Nava Dekel, Alon Chen   +8 more
doaj   +2 more sources

BNST CRF receptor type 1 modulates mechanical hypersensitivity induced by adolescent alcohol exposure in adult female mice. [PDF]

Psychopharmacology (Berl)
Alcohol exposure during adolescence has been linked to long-lasting behavioral consequences, contributing to the development of alcohol use disorder. Negative affect and chronic pain during alcohol withdrawal are critical factors influencing problematic alcohol use and relapse.
Bertagna NB, Holmgren EB, Engi SA, Ha L, Cruz FC, Albrechet-Souza L, Wills TA.   +6 more
europepmc   +3 more sources

The Role of Corticotropin-Releasing Factor (CRF) and CRF-Related Peptides in the Social Behavior of Rodents

Biomedicines, 2023
Since the corticotropin-releasing factor (CRF) was isolated from an ovine brain, a growing family of CRF-related peptides has been discovered. Today, the mammalian CRF system consists of four ligands (CRF, urocortin 1 (Ucn1), urocortin 2 (Ucn2), and ...
Zsolt Bagosi, Kíra Megyesi, Jázmin Ayman, Hanna Rudersdorf, Maieda Khan Ayaz, Krisztina Csabafi   +5 more
doaj   +1 more source

CRF-R1 Antagonist Treatment Exacerbates Circadian Corticosterone Secretion under Chronic Stress, but Preserves HPA Feedback Sensitivity

Pharmaceutics, 2021
Despite promising initial reports, corticotropin-releasing factor receptor type-1 (CRF-R1) antagonists have mostly failed to display efficacy in clinical trials for anxiety or depression.
Yadira Ibarguen-Vargas, Samuel Leman, Rupert Palme, Catherine Belzung, Alexandre Surget   +4 more
doaj   +1 more source

The newly developed CRF1-receptor antagonists, NGD 98-2 and NGD 9002, suppress acute stress-induced stimulation of colonic motor function and visceral hypersensitivity in rats. [PDF]

, 2013
Corticotropin releasing factor receptor 1 (CRF1) is the key receptor that mediates stress-related body responses. However to date there are no CRF1 antagonists that have shown clinical efficacy in stress-related diseases.
Czimmer, József, Hoffman, Diane C, Kehne, John, Luckey, Andrew, Maynard, George D, Million, Mulugeta, Taché, Yvette, Zhao, Jing-Fang   +7 more
core   +8 more sources

Opposing actions of CRF-R1 and CB1 receptor on facial stimulation-induced MLI-PC plasticity in mouse cerebellar cortex

BMC Neuroscience, 2022
Background Corticotropin-releasing factor (CRF) is the major neuromodulator orchestrating the stress response, and is secreted by neurons in various regions of the brain.
Guang-Gao Li, Chun-Jian Piao, Peng Wan, Shu-Yu Li, Yu-Xuan Wei, Guo-Jun Zhao, Wen-Yuan Wu, Lan Hong, Chun-Ping Chu, De-Lai Qiu   +9 more
doaj   +1 more source