Stress History Modulates Corticotropin-Releasing Factor Neurons to Establish Resilience [PDF]
Biological Psychiatry Global Open ScienceBackground: Cumulative stress is a major risk factor for developing major depressive disorder (MDD), but not everyone experiencing chronic stress develops MDD.
Sherod E. Haynes +14 more
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Corticotropin‐releasing factor is involved in acute stress‐induced analgesia and antipruritus [PDF]
Brain and Behavior, 2022 Background Under the condition of stress, the hypothalamic–pituitary–adrenal axis (HPA axis) is activated and causes the secretion of corticotropin‐releasing factor (CRF).
Xiao‐Dong Wang +8 more
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The effects of corticotropin-releasing factor on motor learning [PDF]
Scientific ReportsCorticotropin-releasing factor (CRF) is mainly secreted from the hypothalamic paraventricular nuclei and plays a crucial role in stress-related responses. Recent studies have reported that CRF is a neuromodulator in the central nervous system.
Eri Takeuchi +4 more
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Interactions between corticotropin releasing factor signaling and prophylactic antibiotics on measures of intestinal function in weaned and transported pigs [PDF]
Frontiers in Physiology, 2023 The study objective was to evaluate the interaction between corticotrophin releasing factor (CRF) receptor signaling and prophylactic antibiotic administration on intestinal physiology in newly weaned and transported pigs.
Betty R. McConn +7 more
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Вавиловский журнал генетики и селекции, 2021 Stress is an essential part of everyday life. The neuropeptide corticotropin-releasing hormone (CRH, also called CRF and corticoliberin) plays a key role in the integration of neuroendocrine, autonomic and behavioral responses to stress.
E. V. Sukhareva
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The newly developed CRF1-receptor antagonists, NGD 98-2 and NGD 9002, suppress acute stress-induced stimulation of colonic motor function and visceral hypersensitivity in rats. [PDF]
, 2013 Corticotropin releasing factor receptor 1 (CRF1) is the key receptor that mediates stress-related body responses. However to date there are no CRF1 antagonists that have shown clinical efficacy in stress-related diseases.
Czimmer, József +7 more
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Stress-Derived Corticotropin Releasing Factor Breaches Epithelial Endotoxin Tolerance. [PDF]
PLoS ONE, 2013 Loss of the endotoxin tolerance of intestinal epithelium contributes to a number of intestinal diseases. The etiology is not clear. Psychological stress is proposed to compromise the intestinal barrier function.
Yong Yu +8 more
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Inconsistent stimulation of plasma ACTH through corticotropin-releasing factor in a patient with central Cushing's disease due to pituitary adenoma [PDF]
, 1985 Three uncommon findings were observed in a case of Cushing's disease due to macroadenoma: no suppression of plasma ACTH during an 8-mg dexamethasone test, a negative corticotropin-releasing factor test, and a normal X-ray of the sella turcica.
Lüdecke, D. K. +2 more
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Trends in Psychiatry and Psychotherapy, 2020 Introduction In addition to their role in regulation of the hypothalamic-pituitary-adrenal-axis, corticotropin-releasing factor (CRF) and its related peptides, the urocortins, are important mediators of physiological and pathophysiological processes of ...
Mailton Vasconcelos +4 more
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Communications Biology, 2022 Viral retrograde tracing identifies input regions and patterns into the corticotropin releasing factor-expressing neurons in central amygdala, providing an important resource to disentangle the role of these cells in fear and anxiety.
Chuan Huang +7 more
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