Results 21 to 30 of about 29,028 (227)

Regulation of gonadotropins by corticotropin-releasing factor and urocortin

Frontiers in Endocrinology, 2013
While stress activates the hypothalamic-pituitary-adrenal (HPA) axis, it suppresses the hypothalamic-pituitary-gonadal (HPG) axis. Corticotropin-releasing factor (CRF) is a major regulatory peptide in the HPA axis during stress.
Kazunori eKageyama
doaj   +1 more source

Detrimental Role of Corticotropin-Releasing Factor on the Decrease of CA1 Field Potential Induced by In Vitro Ischemia in Rat Hippocampal Slices

Journal of Pharmacological Sciences, 2004
This experiment was designed to test the hypothesis that endogenous corticotropin-releasing factor (CRF) contributes to the neurodegenerative process following an ischemic insult.
Yoshifumi Kagamiishi, Tsuneyuki Yamamoto, Shigenori Watanabe   +2 more
doaj   +1 more source

Corticotropin-releasing factor-related peptides, serotonergic systems, and emotional behavior

Frontiers in Neuroscience, 2013
Corticotropin-releasing factor (CRF) is a 41-amino acid neuropeptide that is involved in stress-related physiology and behavior, including control of the hypothalamic-pituitary-adrenal (HPA) axis.
James H Fox, Christopher A Lowry
doaj   +1 more source

Human fear acquisition deficits in relation to genetic variants of the corticotropin releasing hormone receptor 1 and the serotonin transporter. [PDF]

PLoS ONE, 2013
The ability to identify predictors of aversive events allows organisms to appropriately respond to these events, and failure to acquire these fear contingencies can lead to maladaptive contextual anxiety.
Ivo Heitland, Lucianne Groenink, Elisabeth Y Bijlsma, Ronald S Oosting, Johanna M P Baas   +4 more
doaj   +1 more source

Corticotropin-Releasing Hormone: Biology and Therapeutic Opportunities

Biology, 2022
In 1981, Wylie Vale, Joachim Spiess, Catherine Rivier, and Jean Rivier reported on the characterization of a 41-amino-acid peptide from ovine hypothalamic extracts with high potency and intrinsic activity stimulating the secretion of adrenocorticotropic ...
Alessandra Caruso, Alessandra Gaetano, Sergio Scaccianoce   +2 more
doaj   +1 more source

Transcriptional regulation of corticotropin-releasing hormone gene in stress response

IBRO Reports, 2018
As a central player of the hypothalamic-pituitary-adrenal (HPA) axis, the corticotropin -releasing hormone (CRH) neurons in the hypothalamic paraventricular nucleus (PVN) determine the state of HPA axis and play a key role in stress response.
Jiang-Ning Zhou, Hui Fang
doaj   +1 more source

Sex differences in corticotropin releasing factor regulation of medial septum-mediated memory formation

Neurobiology of Stress, 2019
Stress can disrupt memory and contribute to cognitive impairments in psychiatric disorders, including schizophrenia and attention deficit hyperactivity disorder.
Kimberly R. Wiersielis, Attilio Ceretti, Arron Hall, Sydney T. Famularo, Madeleine Salvatore, Alexandra S. Ellis, Harah Jang, Mathieu E. Wimmer, Debra A. Bangasser   +8 more
doaj   +1 more source

The physiology of corticotropin-releasing factor (CRF) [PDF]

Reproduction Nutrition Développement, 1985
Corticotropin-releasing factor (CRF) was characterized, purified and synthesized in 1981 by Vale. The composition of this 41 amino-acid peptide varies slightly from one species to another. Its principal origin is the paraventricular nucleus of the hypothalamus and, by the portal vessels, it reaches the adenohypophysis where it stimulates the ...
Raux-Demay, Marie-Charles, Girard, F.
openaire   +3 more sources

Conjugated Metal‐Organic Frameworks on Laser‐Induced‐Graphene Scaffold Enable Picomolar Sensitivity in Electrical Biosensors

Advanced Materials Interfaces, EarlyView.
A controlled layer‐by‐layer growth process integrates conjugated metal‐organic framework thin films onto a hierarchical 3D laser‐induced graphene scaffold. When incorporated into an extended‐gate field‐effect transistor configuration, this synergistic hybrid platform achieves robust aptamer immobilization, driving highly selective, picomolar‐level ...
Khanh T. M. Le, Tuan‐Khoa Nguyen, Nam‐Trung Nguyen   +2 more
wiley   +1 more source

Palatable‐Food–Driven Top‐Down Circuit Inhibits PVNCRF Activity to Mitigate Stress Via Peri‐PVNCRFR1 Neurons

Advanced Science, EarlyView.
Palatable food alleviates stress and prevents anxiety. This study uncovers a dedicated neural pathway: dopamine release in the PFC activates D1R neurons, whose projections to the peri‐PVN engage a population of anxiolytic CRFR1 neurons. These neurons then inhibit stress‐induced hyperactivity of PVNCRF neurons, providing a circuit‐level explanation for ...
Yuchuan Hong, Shirui Jun, Tianjiao Deng, Gaojie Shao, Dan Liu, Yi Sun, Yan Chen, Qian Xiao, Jie Shao, Sheng Wang, Tianwen Huang, Fan Yang, Jie Tu   +12 more
wiley   +1 more source