Results 31 to 40 of about 29,028 (227)
Nature Communications, 2016 Innate animal behaviours can be negatively regulated by environmental stressors. Jee et al. show that suppression of male C. eleganscopulation behaviour by noxious light can be overcome by activation of SEB-3, a homologue of the stress-associated ...
Changhoon Jee +3 more
doaj +1 more source
Advanced Science, EarlyView.Early life adversity triggers persistent social subordination and brain‐wide molecular dysregulation. Pharmacological inhibition of the stress‐mediator FKBP51 during the adversity period prevents these long‐term deficits and restores normative social hierarchy.
Joeri Bordes +15 more
wiley +1 more source
Hypothalamic Control of Liver Health and Disease: From Circuits to Pathophysiology and Therapies
Advanced Science, EarlyView.This review delineates the hypothalamic circuits that control liver homeostasis via autonomic and neuroendocrine pathways. Dysregulation of this hypothalamus–liver axis drives disease progression across a spectrum including steatotic liver disease, liver inflammation and injury, fibrosis, cirrhosis, and hepatocellular carcinoma.
Qin Tang +7 more
wiley +1 more source
Frontiers in Behavioral Neuroscience, 2017 The ability of many drugs of abuse, including cocaine, to mediate reinforcement and drug-seeking behaviors is in part mediated by the corticotropin-releasing hormone (CRH) system, in which CRH exerts its effects partly via the CRH receptor subtype 1 ...
Rick E. Bernardi +6 more
doaj +1 more source
POEMS Syndrome: 2026 Update on Diagnosis, Risk‐Stratification, and Management
American Journal of Hematology, EarlyView.ABSTRACT Disease Overview POEMS syndrome is a life‐threatening syndrome due to an underlying plasma cell neoplasm. The major criteria for the syndrome are polyneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and the presence of Castleman disease.
Angela Dispenzieri
wiley +1 more source
Short-Term Sleep Fragmentation Dysregulates Autophagy in a Brain Region-Specific Manner
Life, 2021 In this study, we investigated autophagy, glial activation status, and corticotropin releasing factor (CRF) signaling in the brains of mice after 5 days of sleep fragmentation (SF).
Yan Cheng +4 more
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley +1 more source
The role of CRF family peptides in the regulation of food intake and anxiety-like behavior
Biomolecular Concepts, 2011 Corticotropin-releasing factor (CRF) and the urocortins (UCN1, UCN2, and UCN3) belong to the CRF family of peptides and are the major regulators of the adaptive response to internal and external stresses.
Nakayama Naoko +7 more
doaj +1 more source
Altered maternal profiles in corticotropin-releasing factor receptor 1 deficient mice
BMC Neuroscience, 2007 Background During lactation, the CNS is less responsive to the anxiogenic neuropeptide, corticotropin-releasing factor (CRF). Further, central injections of CRF inhibit maternal aggression and some maternal behaviors, suggesting decreased CRF ...
Bethea Emily D +2 more
doaj +1 more source
Translational Psychiatry, 2021 Biological responses to stress are complex and highly conserved. Corticotropin-releasing factor (CRF) plays a central role in regulating these lifesaving physiological responses to stress.
Dorien Vandael +7 more
doaj +1 more source