Results 51 to 60 of about 29,028 (227)

Corticotropin-releasing Factor Receptor 2 Mediates Sex-Specific Cellular Stress Responses

Molecular Medicine, 2013
Although females suffer twice as much as males from stress-related disorders, sex-specific participating and pathogenic cellular stress mechanisms remain uncharacterized. Using corticotropin-releasing factor receptor 2-deficient (Crhr2−/−) and wild-type (
Eric Kubat, Shilpi Mahajan, Min Liao, Larry Ackerman, Peter T. Ohara, Eileen F. Grady, Aditi Bhargava   +6 more
doaj   +1 more source

Prenatal betamethasone–postnatal N‐methyl‐D‐aspartic acid model of spasms: Update on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Infantile epilepsy spasms syndrome (IESS), formerly known as infantile spasms or West Syndrome, is a severe epilepsy syndrome affecting about 3 in 10,000 newborns in the United States. Characterized by clusters of epileptic spasms, interictal hypsarrhythmia, and developmental delays, IESS has diverse causes, including structural‐metabolic ...
Kayla Vieira, Antonia Schonwald, Chian‐Ru Chern, Kamya Shah, Jana Velíšková, Libor Velíšek   +5 more
wiley   +1 more source

Dissecting the Roles of GABA and Neuropeptides from Rat Central Amygdala CRF Neurons in Anxiety and Fear Learning

Cell Reports, 2019
Summary: Central amygdala (CeA) neurons that produce corticotropin-releasing factor (CRF) regulate anxiety and fear learning. These CeACRF neurons release GABA and several neuropeptides predicted to play important yet opposing roles in these behaviors ...
Matthew B. Pomrenze, Simone M. Giovanetti, Rajani Maiya, Adam G. Gordon, Lauren J. Kreeger, Robert O. Messing   +5 more
doaj   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Cooperative CRF and α1 Adrenergic Signaling in the VTA Promotes NMDA Plasticity and Drives Social Stress Enhancement of Cocaine Conditioning

Cell Reports, 2018
Summary: Stressful events rapidly trigger activity-dependent synaptic plasticity, driving the formation of aversive memories. However, it remains unclear how stressful experience affects plasticity mechanisms to regulate appetitive learning, such as ...
Jorge Tovar-Díaz, Matthew B. Pomrenze, Russell Kan, Bahram Pahlavan, Hitoshi Morikawa   +4 more
doaj   +1 more source

Maternal and infant gut microbiome

iMeta, EarlyView.
The maternal–infant continuum involves critical windows of host–microbiota co‐adaptation. Preconception, maternal and paternal microbiomes modulate immunity and reproduction. During pregnancy, a gut–placenta axis emerges, where microbial metabolites influence fetal growth or contribute to complications like gestational diabetes mellitus (GDM ...
Huidi Wang, Felicia Tin, Hui Chen, Fuxin Jiao, Min Wu, Shanshan Sun, Lisha Lin, Die Li, Huimin Zheng, Zhenxin Niu, Mengyao Lan, Bahtiyar Yilmaz, Johan G. Eriksson, Mengjia Wang, Andrew Macpherson, Jose C. Clemente, Jia Xu, Ri‐hua Xie, Xiaojiao Zheng, Tao Zhou, Jinfeng Wang, Wei Shen, Bing Huang, Xia Chen, Hai Li, Yan He   +25 more
wiley   +1 more source

Potential Regulatory Effects of Corticotropin-Releasing Factor on Tight Junction-Related Intestinal Epithelial Permeability are Partially Mediated by CK8 Upregulation

Cellular Physiology and Biochemistry, 2017
Background/Aims: Intestinal permeability and stress have been implicated in the pathophysiology of irritable bowel syndrome (IBS). Cytokeratin 8 (CK8), for the first time, has been shown to mediate corticotropin-releasing factor (CRF)-induced changes in ...
Hu Yue, Lu  Bin, Chen Chaoying, Zhang Meng, Li Meng, Wang Xi   +5 more
doaj   +1 more source

Offspring Global DNA Methylation is not Affected by Parental Developmental Stress Experience in a Passerine Species

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT Rapid phenotypic change may be mediated by intergenerational transmission of early developmental experiences. In birds, exposure to glucocorticoids during early development can alter global DNA methylation and gene expression. However, DNA methylation is labile, and it is currently unclear whether the impacts of stress suffered during juvenile
Anna Miltiadous, Harrison J. F. Eyck, Ondi L. Crino, Lee A. Rollins, Damien Callahan, Katherine L. Buchanan   +5 more
wiley   +1 more source

CRF1 receptor activation increases the response of neurons in the basolateral nucleus of the amygdala to afferent stimulation

Frontiers in Behavioral Neuroscience, 2008
The basolateral nucleus (BLA) of the amygdala contributes to the consolidation of memories for emotional or stressful events. The nucleus contains a high density of CRF1 receptors that are activated by corticotropin-releasing factor (CRF).
doaj   +1 more source

Corticotropin-Releasing Factor and the Brain-Gut Motor Response to Stress

Canadian Journal of Gastroenterology, 1999
The characterization of corticotropin-releasing factor (CRF) and CRF receptors, and the development of specific CRF receptor antagonists selective for the receptor subtypes have paved the way to the understanding of the biochemical coding of stress ...
Yvette Taché, Vicente Martinez, Mulugeta Million, Jean Rivier   +3 more
doaj   +1 more source