Results 71 to 80 of about 29,028 (227)
Environmental Health and Preventive Medicine, 2017 Background Chronic noise exposure has been associated with tau hyperphosphorylation and Alzheimer’s disease (AD)-like pathological changes, but the underlying mechanism is unknown. In this study, we explored the effects of long-term noise exposure on the
Zhihui Gai +7 more
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Purification of Hypothalamic Corticotropin Releasing Factor.
Experimental Biology and Medicine, 1960 SummaryFractionation of a crude extract of calf median eminence on carboxymethyl-cellulose columns yields a preparation which induces adrenal ascorbic acid depletion in the median eminence lesioned rat. This partially purified corticotropin releasing factor (CRF) is substantially free from corticotropic and pressor activities.
P C, ROYCE, G, SAYERS
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Developing an evidence‐based model to implement co‐governance
Australian Journal of Public Administration, EarlyView.Abstract Governments are seeking innovative ways to address complex policy issues in increasingly fragmented and fiscally constrained service contexts. Co‐governance is a relatively new mechanism for facilitating collective decision‐making between government and other stakeholders. Effective co‐governance can be difficult to establish and resource‐ and
Shona Marie Bates +4 more
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Calcitonin‐like diuretic hormone influences reproduction in adult female Rhodnius prolixus
Insect Science, EarlyView.Highlights • CT/DH‐like immunoreactivity is present in female reproductive tissues • CT/DH receptor transcripts are expressed in the fat body and ovaries • RNAi knockdown of CT/DH receptors reduces egg number and hatching rate • Rhopr‐CT/DH increases RhoprVg1 and RhoprVgR expression in ovaries in vitro • Rhopr‐CT/DH stimulates oviduct contractions in a
Areej N. Al‐Dailami +2 more
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Integrative Zoology, EarlyView.18 days of predator odor exposure altered gut microbiota, increased anxiety‐like behaviors, and elevated hypothalamic–pituitary–adrenal axis activity in Brandt's voles, with males showing behavioral habituation and females remaining sensitive. Cecal microbiota transplantation experiments confirmed that only female recipients of microbiota from predator‐
Chen Gu +6 more
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Integrative Zoology, EarlyView.Social rank in greater long‐tailed hamsters (Tscherskia triton) shapes gut microbiota composition and metabolite profiles. Dominant males exhibit a “high‐vigilance, metabolically activated” phenotype, with elevated aggression and specific gut microbiota enriched in energy‐harvesting taxa and fecal queuine.
Da Zhang, Xiaoming Xu, Zhibin Zhang
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Distribution of Urocortins and Corticotropin-Releasing Factor Receptors in the Cardiovascular System
International Journal of Endocrinology, 2012 Urocortins are human homologues of urotensin I, a fish corticotropin-releasing-factor- (CRF-) like peptide secreted from the urophysis. There are three urocortins: urocortin 1, urocortin 2, and urocortin 3 in mammals.
Kazuhiro Takahashi
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Amylin analogues as a novel perspective in anti‐obesity therapy
British Journal of Pharmacology, EarlyView.Abstract Public health systems face a major challenge because of the worldwide obesity epidemic. The number of obese individuals has increased dramatically and, even in Switzerland which may be considered a relatively “lean” country, the numbers are alarmingly high and have reached almost 50% of the adult population.
Thomas A. Lutz
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Corticotropin-releasing factor in antinociception and inflammation
European Journal of Pharmacology, 1997 Corticotropin-releasing factor (CRF) plays a major role at the level of the hypothalamus and pituitary to control the body's response mechanisms to stressful stimuli. The recent discovery of CRF outside the central nervous system suggests that CRF may well play a similar role in peripheral tissues, most likely in a paracrine manner.
M, Schäfer, S A, Mousa, C, Stein
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British Journal of Pharmacology, EarlyView.Background and Purpose Aldosterone plays a key role in blood pressure and volume regulation. Enhanced aldosterone secretion contributes to cardiovascular and renal diseases. Therefore, inhibitors of aldosterone receptors and synthase are essential drugs for the treatment of hypertension and heart failure.
Sanika Mohagaonkar +6 more
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