Results 41 to 50 of about 56,895 (205)

The onset of labor alters corticotropin-releasing hormone type 1 receptor variant expression in human myometrium : putative role of interleukin-1ß [PDF]

open access: yes, 2007
CRH targets the human myometrium during pregnancy. The efficiency of CRH actions is determined by expression of functional receptors (CRH-R), which are dynamically regulated.
Grammatopoulos, Dimitris   +6 more
core   +1 more source

Effects of loperamide on the human hypothalamo-pituitary-adrenal axis in vivo and in vitro. [PDF]

open access: yes, 1992
Loperamide, an opiate agonist of high specificity for p-receptors, was recently reported to suppress ACTH and cortisol levels in normal subjects, but not in patients with proven ACTH-dependent Cushing’s disease. However, there is little information on
Auernhammer, Christoph J.   +4 more
core   +1 more source

Maternal corticotropin-releasing hormone is associated with LEP DNA methylation at birth and in childhood: an epigenome-wide study in Project Viva [PDF]

open access: yes, 2018
BackgroundCorticotropin-releasing hormone (CRH) plays a central role in regulating the secretion of cortisol which controls a wide range of biological processes. Fetuses overexposed to cortisol have increased risks of disease in later life.
A Cardenas   +72 more
core   +1 more source

Stress-Induced Reinstatement of Drug Seeking: 20 Years of Progress [PDF]

open access: yes, 2015
In human addicts, drug relapse and craving are often provoked by stress. Since 1995, this clinical scenario has been studied using a rat model of stress-induced reinstatement of drug seeking.
A Cippitelli   +291 more
core   +2 more sources

Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats. [PDF]

open access: yes, 2019
The activation of a neuronal ensemble in the central nucleus of the amygdala (CeA) during alcohol withdrawal has been hypothesized to induce high levels of alcohol drinking in dependent rats.
Crawford, Elena   +8 more
core   +2 more sources

Corticotropin-releasing hormone interacts with interleukin-1 to regulate prostaglandin H synthase-2 expression in human myometrium during pregnancy and labor [PDF]

open access: yes, 2013
Context: The onset of labor appears to involve the activation of myometrial inflammatory pathways, and transcription factors such as nuclear factor-κB (NF-κB) control expression of the contraction-associated proteins required to induce a procontractile ...
Bari, Muhammad F.   +4 more
core   +1 more source

CRF-like receptor SEB-3 in sex-common interneurons potentiates stress handling and reproductive drive in C. elegans

open access: yesNature Communications, 2016
Innate animal behaviours can be negatively regulated by environmental stressors. Jee et al. show that suppression of male C. eleganscopulation behaviour by noxious light can be overcome by activation of SEB-3, a homologue of the stress-associated ...
Changhoon Jee   +3 more
doaj   +1 more source

Short-Term Sleep Fragmentation Dysregulates Autophagy in a Brain Region-Specific Manner

open access: yesLife, 2021
In this study, we investigated autophagy, glial activation status, and corticotropin releasing factor (CRF) signaling in the brains of mice after 5 days of sleep fragmentation (SF).
Yan Cheng   +4 more
doaj   +1 more source

Orexin-Corticotropin-Releasing Factor Receptor Heteromers in the Ventral Tegmental Area as Targets for Cocaine [PDF]

open access: yes, 2015
Release of the neuropeptides corticotropin-releasing factor (CRF) and orexin-A in the ventral tegmental area (VTA) play an important role in stress-induced cocaine-seeking behavior.
Aguinaga, David   +17 more
core   +1 more source

Dissociable Role of Corticotropin Releasing Hormone Receptor Subtype 1 on Dopaminergic and D1 Dopaminoceptive Neurons in Cocaine Seeking Behavior

open access: yesFrontiers in Behavioral Neuroscience, 2017
The ability of many drugs of abuse, including cocaine, to mediate reinforcement and drug-seeking behaviors is in part mediated by the corticotropin-releasing hormone (CRH) system, in which CRH exerts its effects partly via the CRH receptor subtype 1 ...
Rick E. Bernardi   +6 more
doaj   +1 more source

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