Results 11 to 20 of about 29,028 (227)

Central corticotropin releasing factor and social stress

Frontiers in Neuroscience, 2013
Social interactions are a main source of stress in vertebrates. Social stressors, as well as other stressors, activate the hypothalamic-pituitary-adrenal (HPA) axis resulting in glucocorticoid release.
Tobias eBackström, Svante eWinberg
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Pretreatment with a CRF antagonist amplifies feeding inhibition induced by fourth ventricular cocaine- and amphetamine-regulated transcript peptide

BMC Neuroscience, 2019
Background Pre-treatment with the corticotropin-releasing factor antagonist α-helical CRF9-41 prevents inhibition of gastric emptying by cocaine-and amphetamine-regulated transcript peptide at a dorsal hindbrain level, but its inhibition of sucrose ...
Ulrika Smedh, Karen A. Scott, Timothy H. Moran   +2 more
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Corticotropin releasing factor (CRF) systems: Promoting cocaine pursuit without distress via incentive motivation.

PLoS ONE, 2022
Corticotropin releasing factor (CRF) systems in limbic structures are posited to mediate stress-induced relapse in addiction, traditionally by generating distress states that spur drug consumption as attempts at hedonic self-medication.
Hannah M Baumgartner, Madeliene Granillo, Jay Schulkin, Kent C Berridge   +3 more
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Structure insights into selective coupling of G protein subtypes by a class B G protein-coupled receptor

Nature Communications, 2022
Here, the authors report structures of corticotropin releasing factor receptor 2 (CRF2R) bound to agonist Urocortin 1 (UCN1) and coupled to G proteins G11 and Go, offering insight into the structural basis for the ability of CRF2R to couple with multiple
Li-Hua Zhao, Jingyu Lin, Su-Yu Ji, X. Edward Zhou, Chunyou Mao, Dan-Dan Shen, Xinheng He, Peng Xiao, Jinpeng Sun, Karsten Melcher, Yan Zhang, Xiao Yu, H. Eric Xu   +12 more
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The paraventricular thalamus provides a polysynaptic brake on limbic CRF neurons to sex-dependently blunt binge alcohol drinking and avoidance behavior in mice

Nature Communications, 2021
Bed nucleus of the stria terminalis (BNST) neurons that synthesize and release the stress neuropeptide corticotropin-releasing factor drive binge alcohol drinking and anxiety.
Olivia B. Levine, Mary Jane Skelly, John D. Miller, Jean K. Rivera-Irizarry, Sydney A. Rowson, Jeffrey F. DiBerto, Jennifer A. Rinker, Todd E. Thiele, Thomas L. Kash, Kristen E. Pleil   +9 more
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Molecular Modeling of Structures and Interaction of Human Corticotropin-Releasing Factor (CRF) Binding Protein and CRF Type-2 Receptor

Frontiers in Endocrinology, 2018
The corticotropin-releasing factor (CRF) system is a key mediator of the stress response and addictive behavior. The CRF system includes four peptides: The CRF system includes four peptides: CRF, urocortins I–III, CRF binding protein (CRF-BP) that binds ...
Paula G. Slater, Sebastian E. Gutierrez-Maldonado, Katia Gysling, Carlos F. Lagos   +3 more
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Chia seeds oil ameliorate chronic immobilization stress-induced neurodisturbance in rat brains via activation of the antioxidant/anti-inflammatory/antiapoptotic signaling pathways

Scientific Reports, 2023
Chronic immobilization stress plays a key role in several neuropsychiatric disorders. This investigation assessed the possible ameliorative effect of chia seed oil (CSO) against the neurodisturbance-induced in rats by chronic immobilization.
Norhan E. Khalifa, Ahmed E. Noreldin, Asmaa F. Khafaga, Mohamed El-Beskawy, Eman Khalifa, Ali H. El-Far, Abdel-Hasseb A. Fayed, Abdeldayem Zakaria   +7 more
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Corticotropin Releasing Factor promotes breast cancer cell motility and invasiveness

Molecular Cancer, 2009
Introduction Cancer cells secrete bioactive peptides that act in an autocrine or paracrine fashion affecting tumor growth and metastasis. Corticotropin-releasing factor (CRF), a hypothalamic neuropeptide that controls the response to stress, has been ...
Stournaras Christos, Andreakou Erini, Rassouli Olga, Karagianni Effie, Venihaki Maria, Dermitzaki Erini, Androulidaki Ariadne, Margioris Andrew N, Tsatsanis Christos   +8 more
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Evaluation of Alcohol Preference and Drinking in msP Rats Bearing a Crhr1 Promoter Polymorphism

Frontiers in Psychiatry, 2018
Alcoholism is a pervasive societal problem, yet available pharmacotherapies fail to treat most sufferers. The type 1 corticotropin-releasing factor (CRF1) receptor has received much attention for its putative role in the progression to alcohol dependence,
Marian L. Logrip, Marian L. Logrip, John R. Walker, Lydia O. Ayanwuyi, Valentina Sabino, Valentina Sabino, Roberto Ciccocioppo, George F. Koob, Eric P. Zorrilla   +8 more
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Moderate white light exposure enhanced spatial memory retrieval by activating a central amygdala-involved circuit in mice

Communications Biology, 2023
Light exposure can profoundly affect neurological functions and behaviors. Here, we show that short-term exposure to moderate (400 lux) white light during Y-maze test promoted spatial memory retrieval and induced only mild anxiety in mice.
MengJuan Shang, MeiLun Shen, RuoTong Xu, JingYu Du, JiMeng Zhang, Ding OuYang, JunZe Du, JunFeng Hu, ZhiChuan Sun, BingXia Wang, Qian Han, Yang Hu, YiHong Liu, Yun Guan, Jing Li, GuoZhen Guo, JunLing Xing   +16 more
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