Results 11 to 20 of about 29,752 (188)

(3α,5α)3-Hydroxypregnan-20-one (3α,5α-THP) Regulation of the HPA Axis in the Context of Different Stressors and Sex

Biomolecules, 2022
Corticotropin-releasing factor (CRF) regulates the stress response in the hypothalamus and modulates neurotransmission across the brain through CRF receptors.
Giorgia Boero, Ryan E. Tyler, Todd K. O’Buckley, Irina Balan, Joyce Besheer, A. Leslie Morrow   +5 more
doaj   +1 more source

Promoter Analysis of Human Corticotropin-Releasing Factor (CRF) Type 1 Receptor and Regulation by CRF and Urocortin [PDF]

Endocrinology, 2004
AbstractWe report the full genomic organization of the human gene for the corticotropin-releasing factor (CRF) receptor type 1 (CRFR1), with complete mapping of exons 1–14. The 5′ flanking region (2.4 kb) of the gene encoding for human CRFR1 was isolated, sequenced, and characterized.
Kelly L, Parham, Sevasti, Zervou, Emmanouil, Karteris, Rob D, Catalano, Robert W, Old, Edward W, Hillhouse   +5 more
openaire   +2 more sources

G Protein-Coupled Receptor Kinase 2 Involvement in Desensitization of Corticotropin-Releasing Factor (CRF) Receptor Type 1 by CRF in Murine Corticotrophs [PDF]

Endocrinology, 2006
Hypothalamic CRF stimulates synthesis and secretion of ACTH via CRF receptor type 1 (CRFR1) in the anterior pituitary gland. After agonist-activated stimulation of receptor signaling, CRFR1 is down-regulated and desensitized. Generally, it is thought that G protein-coupled receptors may be desensitized by G protein-coupled receptor kinases (GRKs ...
Kazunori, Kageyama, Komaki, Hanada, Takako, Moriyama, Takeshi, Nigawara, Satoru, Sakihara, Toshihiro, Suda   +5 more
openaire   +2 more sources

CRF type 1 receptors in the dorsal periaqueductal gray modulate anxiety-induced defensive behaviors [PDF]

Hormones and Behavior, 2007
The dorsal periaqueductal gray (dPAG) is involved in defensive coping reactions to threatening stimuli. Corticotropin releasing factor (CRF) is substantially implicated as a direct modulator of physiological, endocrine and behavioral responses to a stressor.
Yoav, Litvin, Nathan S, Pentkowski, D Caroline, Blanchard, Robert J, Blanchard   +3 more
openaire   +2 more sources

Prior stress and vasopressin promote corticotropin-releasing factor inhibition of serotonin release in the central nucleus of the amygdala

Frontiers in Behavioral Neuroscience, 2023
Corticotropin-releasing factor (CRF) is essential for coordinating endocrine and neural responses to stress, frequently facilitated by vasopressin (AVP).
Patrick J. Ronan, Patrick J. Ronan, Patrick J. Ronan, Patrick J. Ronan, Wayne J. Korzan, Philip L. Johnson, Christopher A. Lowry, Kenneth J. Renner, Kenneth J. Renner, Cliff H. Summers, Cliff H. Summers, Cliff H. Summers   +11 more
doaj   +1 more source

The anxiolytic effect of environmental enrichment is mediated via amygdalar CRF receptor type 1 [PDF]

Molecular Psychiatry, 2010
Environmental enrichment (EE) is known to have an anxiolytic effect in several animal models; however, the molecular mechanisms underlying these behavioral changes are not understood. In this study, we have shown that the anxiolytic effect of EE is associated with alterations in the corticotropin-releasing factor receptor type 1 (CRFR1) expression ...
Y, Sztainberg, Y, Kuperman, M, Tsoory, M, Lebow, A, Chen   +4 more
openaire   +2 more sources

Musclin prevents depression-like behavior in male mice by activating urocortin 2 signaling in the hypothalamus

Frontiers in Endocrinology, 2023
IntroductionPhysical activity is recommended as an alternative treatment for depression. Myokines, which are secreted from skeletal muscles during physical activity, play an important role in the skeletal muscle-brain axis.
Koji Ataka, Koji Ataka, Akihiro Asakawa, Haruki Iwai, Ikuo Kato   +4 more
doaj   +1 more source

Corticotropin-releasing Factor (CRF) and Urocortin Promote the Survival of Cultured Cerebellar GABAergic Neurons Through the Type 1 CRF Receptor [PDF]

Journal of Korean Medical Science, 2006
Corticotropin releasing factor (CRF) is known to be involved in the stress response and in some degenerative brain disorders. In addition, CRF has a role as a neuromodulator in adult cerebellar circuits. Data from developmental studies suggest a putative role for CRF as a trophic factor during cerebellar development.
Choi, Jae-Sun, Pham, Thao Thi Hien, Jang, Yoon-Jin, Bui, Bao Chi, Lee, Bong-Hee, Joo, Kyeong-Min, Cha, Choong-Ik, Lee, Kyung-Hoon   +7 more
openaire   +2 more sources

Corticotropin-releasing factor receptor signaling and modulation: implications for stress response and resilience

Trends in Psychiatry and Psychotherapy, 2020
Introduction In addition to their role in regulation of the hypothalamic-pituitary-adrenal-axis, corticotropin-releasing factor (CRF) and its related peptides, the urocortins, are important mediators of physiological and pathophysiological processes of ...
Mailton Vasconcelos, Dirson J. Stein, Matheus Gallas-Lopes, Luane Landau, Rosa Maria M. de Almeida   +4 more
doaj   +1 more source

Regulation of Corticotropin-Releasing Factor(CRF) Type-1 Receptor Gene Expression by CRF in the Hypothalamus.

Endocrine Journal, 2003
We reported previously that acute stress and intracerebroventricular (i.c.v.) injection of corticotropin-releasing factor (CRF) increased neuronal activation and CRF type-1 receptor (CRFR-1) mRNA expression in the CRF-producing neurons of the parvocellular paraventricular nucleus (PVN) of the hypothalamus.
Shun-ichiro, Konishi, Yoko, Kasagi, Harumi, Katsumata, Shiro, Minami, Toshihiro, Imaki   +4 more
openaire   +3 more sources