Results 51 to 60 of about 18,708 (168)

Immune Aspects and Myometrial Actions of Progesterone and CRH in Labor

Clinical and Developmental Immunology, 2012
Progesterone and corticotropin-releasing hormone (CRH) have a critical role in pregnancy and labor, as changes related to these hormones are crucial for the transition from myometrial quiescence to contractility.
Nikolaos Vrachnis, Fotodotis M. Malamas, Stavros Sifakis, Panayiotis Tsikouras, Zoe Iliodromiti   +4 more
doaj   +1 more source

A Corticotropin-Releasing Hormone Type I Receptor Antagonist Delays Parturition in Sheep [PDF]

Endocrinology, 1998
In sheep, corticotropin-releasing hormone (CRH) can stimulate the fetal release of ACTH to produce a cortisol surge which leads to the onset of parturition. We tested the hypothesis that fetal CRH is a primary factor in the onset of parturition in sheep by using a Type I CRH receptor antagonist, antalarmin, to block the endogenous action of CRH ...
E C, Chan, J, Falconer, G, Madsen, K C, Rice, E L, Webster, G P, Chrousos, R, Smith   +6 more
openaire   +2 more sources

Corticotropin-Releasing Hormone Family and Their Receptors in the Cardiovascular System

Circulation Journal, 2019
The identification of corticotropin-releasing hormone (CRH) has led to the discovery of a growing family of ligands and receptors. CRH receptor 1 (CRHR1) and CRHR2 are mammalian G-protein coupled receptors (GPCRs) with high affinity for CRH and the CRH family of peptides.
Mikito, Takefuji, Toyoaki, Murohara
openaire   +3 more sources

Corticotropin-Releasing Hormone Receptor-1 and Histidine Decarboxylase Expression in Chronic Urticaria [PDF]

Journal of Investigative Dermatology, 2005
Certain skin disorders, such as contact dermatitis and chronic urticaria, are characterized by inflammation involving mast cells and worsen by stress. The underlying mechanism of this effect, however, is not known. The skin appears to have the equivalent of a hypothalamic-pituitary-adrenal (HPA) axis, including local expression of corticotropin ...
Papadopoulou, Nikoletta, Kalogeromitros, Demetrios, Staurianeas, Nikolaos G., Tiblalexi, Despina, Theoharides, Theoharis C.   +4 more
openaire   +2 more sources

Corticotropin-Releasing Hormone Receptor 1 Gene Variants in Irritable Bowel Syndrome

PLoS ONE, 2012
Corticotropin-releasing hormone (CRH) acts mainly via the CRH receptor 1 (CRH-R1) and plays a crucial role in the stress-induced pathophysiology of irritable bowel syndrome (IBS). Several studies have demonstrated that variants of the CRH-R1 gene carry a potential risk for depression, but evidence for an association between CRH-R1 genotypes and IBS is ...
Naoko Sato, Naoki Suzuki, Ayaka Sasaki, Emiko Aizawa, Takeshi Obayashi, Motoyori Kanazawa, Tomoko Mizuno, Michiko Kano, Masashi Aoki, Shin Fukudo   +9 more
openaire   +4 more sources

Corticotropin-releasing hormone (CRH) alters mitochondrial morphology and function by activating the NF-kB-DRP1 axis in hippocampal neurons

Cell Death and Disease, 2020
Neuronal stress-adaptation combines multiple molecular responses. We have previously reported that thorax trauma induces a transient loss of hippocampal excitatory synapses mediated by the local release of the stress-related hormone corticotropin ...
Chiara R. Battaglia, Silvia Cursano, Enrico Calzia, Alberto Catanese, Tobias M. Boeckers   +4 more
doaj   +1 more source

The Role of Urocortins in Intracerebral Hemorrhage

Biomolecules, 2020
Intracerebral hemorrhage (ICH) causes an accumulation of blood in the brain parenchyma that disrupts the normal neurological function of the brain. Despite extensive clinical trials, no medical or surgical therapy has shown to be effective in managing ...
Ker Woon Choy, Andy Po-Yi Tsai, Peter Bor-Chian Lin, Meng-Yu Wu, Chihyi Lee, Aspalilah Alias, Cheng-Yoong Pang, Hock-Kean Liew   +7 more
doaj   +1 more source

Hypothesis of the neuroendocrine cortisol pathway gene role in the comorbidity of depression, type 2 diabetes, and metabolic syndrome

The Application of Clinical Genetics, 2014
Claudia Gragnoli1,21Center for Biotechnology and Department of Biology, College of Science and Technology, Temple University, Philadelphia, PA, USA; 2Molecular Biology Laboratory, Bios Biotech Multi-Diagnostic Health Center, Rome, ItalyAbstract ...
Gragnoli C
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Endocrinology and the brain: corticotropin-releasing hormone signaling

Endocrine Connections, 2017
Corticotropin-releasing hormone (CRH) is a key player of basal and stress-activated responses in the hypothalamic–pituitary–adrenal axis (HPA) and in extrahypothalamic circuits, where it functions as a neuromodulator to orchestrate humoral and behavioral
Carolina Inda, Natalia G Armando, Paula A dos Santos Claro, Susana Silberstein   +3 more
doaj   +1 more source

Role of the hypothalamic pituitary adrenal axis in the control of the response to stress and infection

Brazilian Journal of Medical and Biological Research, 2000
The release of adrenocorticotropin (ACTH) from the corticotrophs is controlled principally by vasopressin and corticotropin-releasing hormone (CRH). Oxytocin may augment the release of ACTH under certain conditions, whereas atrial natriuretic peptide ...
McCann S.M., Antunes-Rodrigues J., Franci C.R., Anselmo-Franci J.A., Karanth S., Rettori V.   +5 more
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