Results 11 to 20 of about 21,979 (167)

Conditioned Aversion and Neuroplasticity Induced by a Superagonist of Extrasynaptic GABAA Receptors: Correlation With Activation of the Oval BNST Neurons and CRF Mechanisms

Frontiers in Molecular Neuroscience, 2019
THIP (gaboxadol), a superagonist of the δ subunit-containing extrasynaptic GABAA receptors, produces persistent neuroplasticity in dopamine (DA) neurons of the ventral tegmental area (VTA), similarly to rewarding drugs of abuse. However, unlike them THIP
Elena de Miguel, Olga Vekovischeva, Lauri V. Elsilä, Anne Panhelainen, Esko Kankuri, Teemu Aitta-aho, Esa R. Korpi   +6 more
doaj   +1 more source

CRHR1 mediates the transcriptional expression of pituitary hormones and their receptors under hypoxia

Frontiers in Endocrinology, 2022
Hypothalamus-pituitary-adrenal (HPA) axis plays critical roles in stress responses under challenging conditions such as hypoxia, via regulating gene expression and integrating activities of hypothalamus-pituitary-targets cells.
Tong Ying Wang, Tong Ying Wang, Tong Ying Wang, Fang Yuan Xia, Fang Yuan Xia, Jing Wen Gong, Xiao Kang Xu, Xiao Kang Xu, Min Chao Lv, Mahanand Chatoo, Mahanand Chatoo, Bilal Haider Shamsi, Bilal Haider Shamsi, Meng Chen Zhang, Meng Chen Zhang, Qian Ru Liu, Qian Ru Liu, Tian Xing Liu, Dan Dan Zhang, Xin Jiang Lu, Yang Zhao, Ji Zeng Du, Xue Qun Chen, Xue Qun Chen   +23 more
doaj   +1 more source

Photoaffinity labeling of corticotropin receptors. [PDF]

Proceedings of the National Academy of Sciences, 1980
A photoaffinity label for corticotropin (ACTH) receptors was prepared by selective chemical modification of the single tryptophan residue in the hormone by reaction with 2-nitro-5-azidophenylsulfenyl chloride. The photoreactive derivative, [(2-nitro-5-azidophenylsulfenyl)-Trp9]ACTH (2,5-NAPS-ACTH), stimulated corticosterone synthesis to 60% of the ...
J, Ramachandran, K, Muramoto, M, Kenez-Keri, G, Keri, D I, Buckley   +4 more
openaire   +2 more sources

CRF1/CRF2 and MC3/MC4 Receptors Affect Glutamate- Induced Food Intake in Neonatal Meat-Type Chicken

Brazilian Journal of Poultry Science, 2019
Central glutamate, melanocortin and corticotropin systems have mediatory role on several physiologic functions in the brain, but their interactions on appetite regulation are not fully elicited.
F Ahmadi, M Zendehdel, V Babapour, N Panahi   +3 more
doaj   +1 more source

Corticotropin-Releasing Factor Family: A Stress Hormone-Receptor System’s Emerging Role in Mediating Sex-Specific Signaling

Cells, 2020
No organ in the body is impervious to the effects of stress, and a coordinated response from all organs is essential to deal with stressors. A dysregulated stress response that fails to bring systems back to homeostasis leads to compromised function and ...
Lahari Vuppaladhadiam, Cameron Ehsan, Meghana Akkati, Aditi Bhargava   +3 more
doaj   +1 more source

Corticotropin-releasing factor receptor signaling and modulation: implications for stress response and resilience

Trends in Psychiatry and Psychotherapy, 2020
Introduction In addition to their role in regulation of the hypothalamic-pituitary-adrenal-axis, corticotropin-releasing factor (CRF) and its related peptides, the urocortins, are important mediators of physiological and pathophysiological processes of ...
Mailton Vasconcelos, Dirson J. Stein, Matheus Gallas-Lopes, Luane Landau, Rosa Maria M. de Almeida   +4 more
doaj   +1 more source

Corticotropin-releasing factor-related peptides, serotonergic systems, and emotional behavior

Frontiers in Neuroscience, 2013
Corticotropin-releasing factor (CRF) is a 41-amino acid neuropeptide that is involved in stress-related physiology and behavior, including control of the hypothalamic-pituitary-adrenal (HPA) axis.
James H Fox, Christopher A Lowry
doaj   +1 more source

HYPOTHALAMIC NEUROHORMONES AND IMMUNE RESPONSES

Frontiers in Integrative Neuroscience, 2013
The aim of this review is to provide a comprehensive examination of the current literature describing the neural-immune interactions, with emphasis on the most recent findings of the effects of neurohormones on immune system.
J. Luis eQuintanar, Irene eGuzmán-Soto
doaj   +1 more source

Determinants of Corticotropin Releasing Factor. Receptor Selectivity of Corticotropin Releasing Factor Related Peptides [PDF]

Journal of Medicinal Chemistry, 2004
The corticotropin-releasing factor (CRF) peptide family is an important target in pharmaceutical research. The CRF system consists of two receptors, corticotropin releasing factor receptor 1 (CRF1R) and corticotropin releasing factor receptor 2 (CRF2R), a nonreceptor binding protein, and the peptide agonists of these receptors.
Adam W, Mazur, Feng, Wang, Michelle, Tscheiner, Michelle, Tcheiner, Elizabeth, Donnelly, Robert J, Isfort   +5 more
openaire   +2 more sources

Effects of chronic noise on the corticotropin-releasing factor system in the rat hippocampus: relevance to Alzheimer’s disease-like tau hyperphosphorylation

Environmental Health and Preventive Medicine, 2017
Background Chronic noise exposure has been associated with tau hyperphosphorylation and Alzheimer’s disease (AD)-like pathological changes, but the underlying mechanism is unknown. In this study, we explored the effects of long-term noise exposure on the
Zhihui Gai, Donghong Su, Yawen Wang, Wenlong Li, Bo Cui, Kang Li, Xiaojun She, Rui Wang   +7 more
doaj   +1 more source