Results 11 to 20 of about 42,487 (284)

Corticotropin-releasing hormone receptor antagonists [PDF]

open access: yesEuropean Journal of Endocrinology, 2006
Corticotropin-releasing hormone (CRH), CRH-related peptides, and CRH receptors play major roles in coordinating the behavioral, endocrine, autonomic, and immune responses to stress. The wide influence of the CRH system on physiological processes in both brain and periphery implicates the respective peptides in the pathophysiology of numerous disorders ...
Zoumakis, E.   +2 more
openaire   +2 more sources

Transcriptional regulation of corticotropin-releasing hormone gene in stress response

open access: yesIBRO Reports, 2018
As a central player of the hypothalamic-pituitary-adrenal (HPA) axis, the corticotropin -releasing hormone (CRH) neurons in the hypothalamic paraventricular nucleus (PVN) determine the state of HPA axis and play a key role in stress response.
Jiang-Ning Zhou, Hui Fang
doaj   +1 more source

Actin cytoskeleton-dependent regulation of corticotropin-releasing factor receptor heteromers [PDF]

open access: yes, 2017
Stress responses are highly nuanced and variable, but how this diversity is achieved by modulating receptor function is largely unknown. Corticotropin-releasing factor receptors (CRFRs), class B G protein–coupled receptors, are pivotal in mediating ...
Bhargava, Aditi   +7 more
core   +1 more source

Conditioned Aversion and Neuroplasticity Induced by a Superagonist of Extrasynaptic GABAA Receptors: Correlation With Activation of the Oval BNST Neurons and CRF Mechanisms

open access: yesFrontiers in Molecular Neuroscience, 2019
THIP (gaboxadol), a superagonist of the δ subunit-containing extrasynaptic GABAA receptors, produces persistent neuroplasticity in dopamine (DA) neurons of the ventral tegmental area (VTA), similarly to rewarding drugs of abuse. However, unlike them THIP
Elena de Miguel   +6 more
doaj   +1 more source

CRHR1 mediates the transcriptional expression of pituitary hormones and their receptors under hypoxia

open access: yesFrontiers in Endocrinology, 2022
Hypothalamus-pituitary-adrenal (HPA) axis plays critical roles in stress responses under challenging conditions such as hypoxia, via regulating gene expression and integrating activities of hypothalamus-pituitary-targets cells.
Tong Ying Wang   +23 more
doaj   +1 more source

Corticotropin-releasing factor receptors couple to multiple g-proteins to activate diverse intracellular signaling pathways in mouse hippocampus: role in neuronal excitability and associative learning [PDF]

open access: yes, 2003
Corticotropin-releasing factor (CRF) exerts a key neuroregulatory control on stress responses in various regions of the mammalian brain, including the hippocampus.
Blank, T. (Thomas)   +5 more
core   +2 more sources

Photoaffinity labeling of corticotropin receptors. [PDF]

open access: yesProceedings of the National Academy of Sciences, 1980
A photoaffinity label for corticotropin (ACTH) receptors was prepared by selective chemical modification of the single tryptophan residue in the hormone by reaction with 2-nitro-5-azidophenylsulfenyl chloride. The photoreactive derivative, [(2-nitro-5-azidophenylsulfenyl)-Trp9]ACTH (2,5-NAPS-ACTH), stimulated corticosterone synthesis to 60% of the ...
J, Ramachandran   +4 more
openaire   +2 more sources

Neurobiological Mechanisms That Contribute to Stress-related Cocaine Use [PDF]

open access: yes, 2014
The ability of stressful life events to trigger drug use is particularly problematic for the management of cocaine addiction due to the unpredictable and often uncontrollable nature of stress.
Ahmed   +149 more
core   +2 more sources

Corticotropin-releasing hormone as the homeostatic rheostat of feto-maternal symbiosis and developmental programming In utero and neonatal life [PDF]

open access: yes, 2017
A balanced interaction between the homeostatic mechanisms of mother and the devel- oping organism during pregnancy and in early neonatal life is essential in order to ensure optimal fetal development, ability to respond to various external and internal ...
Alcantara-Alonso   +114 more
core   +3 more sources

Stress-Induced Reinstatement of Drug Seeking: 20 Years of Progress [PDF]

open access: yes, 2015
In human addicts, drug relapse and craving are often provoked by stress. Since 1995, this clinical scenario has been studied using a rat model of stress-induced reinstatement of drug seeking.
A Cippitelli   +291 more
core   +2 more sources

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