Results 31 to 40 of about 34,268 (231)

MOLECULAR EVOLUTION OF GPCRS: Melanocortin/melanocortin receptors [PDF]

Journal of Molecular Endocrinology, 2014
The melanocortin receptors (MCRs) are a family of G protein-coupled receptors that are activated by melanocortin ligands derived from the proprotein, proopiomelanocortin (POMC). During the radiation of the gnathostomes, the five receptors have become functionally segregated (i.e.
Robert M, Dores, Richard L, Londraville, Jeremy, Prokop, Perry, Davis, Nathan, Dewey, Natalie, Lesinski   +5 more
openaire   +2 more sources

Observations on the evolution of the melanocortin receptor gene family: distinctive features of the melanocortin-2 receptor

Frontiers in Neuroscience, 2013
The melanocortin receptors are a gene family in the rhodopsin class of G protein-coupled receptors. Based on the analysis of several metazoan genome databases it appears that the melanocortin receptors are only found in chordates.
Robert Michael Dores
doaj   +1 more source

The melanocortin pathway and energy homeostasis: From discovery to obesity therapy

Molecular Metabolism, 2021
Background: Over the past 20 years, insights from human and mouse genetics have illuminated the central role of the brain leptin-melanocortin pathway in controlling mammalian food intake, with genetic disruption resulting in extreme obesity, and more ...
Giles S.H. Yeo, Daniela Herrera Moro Chao, Anna-Maria Siegert, Zoe M. Koerperich, Mark D. Ericson, Stephanie E. Simonds, Courtney M. Larson, Serge Luquet, Iain Clarke, Shubh Sharma, Karine Clément, Michael A. Cowley, Carrie Haskell-Luevano, Lex Van Der Ploeg, Roger A.H. Adan   +14 more
doaj   +1 more source

Melanocortin Regulation of Inflammation

Frontiers in Endocrinology, 2019
Adrenocorticotropic hormone (ACTH), and α-, β-, and γ-melanocyte-stimulating hormones (α-, β-, γ-MSH), collectively known as melanocortins, together with their receptors (melanocortin receptors), are components of an ancient modulatory system.
Wei Wang, Dong-Yu Guo, Yue-Jun Lin, Ya-Xiong Tao   +3 more
doaj   +1 more source

Modulation of Canine Melanocortin-3 and -4 Receptors by Melanocortin-2 Receptor Accessory Protein 1 and 2

Biomolecules, 2022
The neural melanocortin receptors (MCRs), melanocortin-3 and -4 receptors (MC3R and MC4R), have crucial roles in regulating energy homeostasis. The melanocortin-2 receptor accessory proteins (MRAPs, MRAP1 and MRAP2) have been shown to regulate neural ...
Ren-Lei Ji, Shan-Shan Jiang, Ya-Xiong Tao   +2 more
doaj   +1 more source

G-Protein-Coupled Receptors in Rheumatoid Arthritis: Recent Insights into Mechanisms and Functional Roles

Frontiers in Immunology, 2022
Rheumatoid arthritis (RA) is a chronic inflammatory disease that leads to joint damage and even disability. Although there are various clinical therapies for RA, some patients still have poor or no response.
Jianan Zhao, Jianan Zhao, Jianan Zhao, Kai Wei, Kai Wei, Kai Wei, Ping Jiang, Ping Jiang, Ping Jiang, Cen Chang, Cen Chang, Cen Chang, Lingxia Xu, Lingxia Xu, Lingxia Xu, Linshuai Xu, Linshuai Xu, Linshuai Xu, Yiming Shi, Yiming Shi, Yiming Shi, Shicheng Guo, Shicheng Guo, Dongyi He, Dongyi He, Dongyi He, Dongyi He   +26 more
doaj   +1 more source

Melanocortin regulation of histaminergic neurons via perifornical lateral hypothalamic melanocortin 4 receptors

Molecular Metabolism, 2020
Objective: Histaminergic neurons of the tuberomammillary nucleus (TMN) are wake-promoting and contribute to the regulation of energy homeostasis. Evidence indicates that melanocortin 4 receptors (MC4R) are expressed within the TMN.
Natalie J. Michael, Alexandre Caron, Charlotte E. Lee, Carlos M. Castorena, Syann Lee, Jeffrey M. Zigman, Kevin W. Williams, Joel K. Elmquist   +7 more
doaj   +1 more source

Multiple sclerosis, relapses, and the mechanism of action of adrenocorticotropic hormone (ACTH)

Frontiers in Neurology, 2013
Relapses in multiple sclerosis (MS) are disruptive and frequently disabling for patients, and their treatment is often a challenge to clinicians. Despite progress in the understanding of the pathophysiology of MS and development of new treatments for ...
Amy ePerrin Ross, Aliza eBen-Zacharia, Colleen J Harris, Jennifer eSmrtka   +3 more
doaj   +1 more source

Lateral septum as a melanocortin downstream site in obesity development

Cell Reports, 2023
Summary: The melanocortin pathway is well established to be critical for body-weight regulation in both rodents and humans. Despite extensive studies focusing on this pathway, the downstream brain sites that mediate its action are not clear.
Yuanzhong Xu, Zhiying Jiang, Hongli Li, Jing Cai, Yanyan Jiang, Joshua Otiz-Guzman, Yong Xu, Benjamin R. Arenkiel, Qingchun Tong   +8 more
doaj   +1 more source

Remapping the Synthetic Landscape of α‐Tertiary Alkylamines via Dual‐Functional Catechol

Angewandte Chemie, EarlyView.
A three‐component assembly strategy has been developed for the modular synthesis of hindered α‐tertiary aliphatic amines from readily available precursors through unlocking the dual role of catechol. The practicality of this methodology has been demonstrated in over 90 examples, including compounds that are otherwise difficult to access, along with ...
Chen‐Yan Cai, Yuzuru Kanda, Tian Qin
wiley   +2 more sources