Results 1 to 10 of about 46,881 (189)

Motivational dysregulation with melanocortin 4 receptor haploinsufficiency. [PDF]

NeuroImmune Pharm Ther, 2022
Abstract Obesity, by any standard, is a global health crisis. Both genetic and dietary contributions to the development and maintenance of obesity were integral factors of our experimental design. As mutations of the melanocortin 4 receptors (MC4R) are the leading monogenetic cause of obesity, MC4R haploinsufficient rats were fed a ...
Steiner AM, Roscoe RF, Booze RM, Mactutus CF.   +3 more
europepmc   +3 more sources

MRAP2 modifies the signaling and oligomerization state of the melanocortin-4 receptor [PDF]

Nature Communications
The melanocortin-4 receptor is a G protein-coupled receptor and a key regulator of appetite and metabolism. It can interact with the melanocortin-receptor accessory protein 2, a single transmembrane helix protein known to interact with several different ...
Iqra Sohail, Suli-Anne Laurin, Gunnar Kleinau, Vidicha Chunilal, Andrew Morton, Alfonso Brenlla, Zeynep Cansu Uretmen Kagiali, Marie-José Blouin, Javier A. Tello, Annette G. Beck-Sickinger, Martin J. Lohse, Patrick Scheerer, Michel Bouvier, Peter McCormick, Paolo Annibale, Heike Biebermann   +15 more
doaj   +2 more sources

Regulation of Melanocortin-3 and -4 Receptors by Isoforms of Melanocortin-2 Receptor Accessory Protein 1 and 2

Biomolecules, 2022
The neural melanocortin receptors (MCRs), melanocortin-3 and -4 receptors (MC3R and MC4R), play essential non-redundant roles in the regulation of energy homeostasis. Interaction of neural MCRs and melanocortin-2 receptor accessory proteins (MRAPs, MRAP1
Ren-Lei Ji, Ya-Xiong Tao
doaj   +3 more sources

Melanocortin 4 receptor mutation in obesity. [PDF]

World J Exp Med
Obesity is increasingly prevalent worldwide, with genetic factors contributing to its development. The hypothalamic leptin-melanocortin pathway is central to the regulation of appetite and weight; leptin activates the proopiomelanocortin neurons, leading to the production of melanocortin peptides; these in turn act on melanocortin 4 receptors (MC4R ...
Sridhar GR, Gumpeny L.
europepmc   +3 more sources

Modulation of Canine Melanocortin-3 and -4 Receptors by Melanocortin-2 Receptor Accessory Protein 1 and 2

Biomolecules, 2022
The neural melanocortin receptors (MCRs), melanocortin-3 and -4 receptors (MC3R and MC4R), have crucial roles in regulating energy homeostasis. The melanocortin-2 receptor accessory proteins (MRAPs, MRAP1 and MRAP2) have been shown to regulate neural ...
Ren-Lei Ji, Shan-Shan Jiang, Ya-Xiong Tao   +2 more
doaj   +3 more sources

Dimerization of melanocortin 4 receptor controls puberty onset and body size polymorphism [PDF]

Frontiers in Endocrinology, 2023
Xiphophorus fish exhibit a clear phenotypic polymorphism in puberty onset and reproductive strategies of males. In X. nigrensis and X. multilineatus, puberty onset is genetically determined and linked to a melanocortin 4 receptor (Mc4r) polymorphism of ...
Ruiqi Liu, Ruiqi Liu, Mike Friedrich, Katherina Hemmen, Kerstin Jansen, Mateus C. Adolfi, Manfred Schartl, Manfred Schartl, Katrin G. Heinze   +8 more
doaj   +2 more sources

Structure elucidation of a human melanocortin-4 receptor specific orthosteric nanobody agonist [PDF]

Nature Communications
The melanocortin receptor 4 (MC4R) belongs to the melanocortin receptor family of G-protein coupled receptors and is a key switch in the leptin-melanocortin molecular axis that controls hunger and satiety.
Thomas Fontaine, Andreas Busch, Toon Laeremans, Stéphane De Cesco, Yi-Lynn Liang, Veli-Pekka Jaakola, Zara Sands, Sarah Triest, Simonas Masiulis, Lies Dekeyzer, Noor Samyn, Nicolas Loeys, Lisa Perneel, Melanie Debaere, Murielle Martini, Charlotte Vantieghem, Richa Virmani, Kamila Skieterska, Stephanie Staelens, Rosa Barroco, Maarten Van Roy, Christel Menet   +21 more
doaj   +2 more sources

Targeting melanocortin 4 receptor to treat sleep-disordered breathing in mice [PDF]

The Journal of Clinical Investigation
Weight loss medications are emerging candidates for pharmacotherapy of sleep-disordered breathing (SDB). A melanocortin 4 receptor (MC4R) agonist, setmelanotide (Set), is used to treat obesity caused by abnormal melanocortin and leptin signaling.
Mateus R. Amorim, Noah R. Williams, O. Aung, Melanie Alexis Ruiz, Frederick Anokye-Danso, Junia L. de Deus, Jiali Xiong, Olga Dergacheva, Shannon Bevans-Fonti, Sean M. Lee, Jeffrey S. Berger, Mark N. Wu, Rexford S. Ahima, David Mendelowitz, Vsevolod Y. Polotsky   +14 more
doaj   +2 more sources

Regulation of Melanocortin-4 Receptor Pharmacology by Two Isoforms of Melanocortin Receptor Accessory Protein 2 in Topmouth Culter (Culter alburnus)

Frontiers in Endocrinology, 2020
Melanocortin-4 receptor (MC4R) plays important roles in regulation of multiple physiological processes, and interaction of MC4R and melanocortin receptor accessory protein 2 (MRAP2) is suggested to play pivotal role in energy balance of vertebrates ...
Min Tao, Min Tao, Ren-Lei Ji, Lu Huang, Si-Yu Fan, Ting Liu, Shao-Jun Liu, Ya-Xiong Tao   +7 more
doaj   +3 more sources

Melanocortin 4 receptor signaling in Sim1 neurons permits sexual receptivity in female mice [PDF]

Frontiers in Endocrinology, 2023
IntroductionFemale sexual dysfunction affects approximately 40% of women in the United States, yet few therapeutic options exist for these patients. The melanocortin system is a new treatment target for hypoactive sexual desire disorder (HSDD), but the ...
Erin A. Semple, Mitchell T. Harberson, Baijie Xu, Rebecca Rashleigh, Tori L. Cartwright, Jessica J. Braun, Amy C. Custer, Chen Liu, Jennifer W. Hill, Jennifer W. Hill   +9 more
doaj   +2 more sources