Results 1 to 10 of about 60,346 (220)

Melanocortin receptor accessory proteins in adrenal disease and obesity [PDF]

Frontiers in Neuroscience, 2015
Melanocortin receptor accessory proteins (MRAPs) are regulators of the melanocortin receptor family. MRAP is an essential accessory factor for the functional expression of the MC2R/ACTH receptor.
David eJackson, Shwetha eRamachandrappa, Adrian eClark, Li eChan   +3 more
doaj   +4 more sources

MRAP2 modifies the signaling and oligomerization state of the melanocortin-4 receptor [PDF]

Nature Communications
The melanocortin-4 receptor is a G protein-coupled receptor and a key regulator of appetite and metabolism. It can interact with the melanocortin-receptor accessory protein 2, a single transmembrane helix protein known to interact with several different ...
Iqra Sohail, Suli-Anne Laurin, Gunnar Kleinau, Vidicha Chunilal, Andrew Morton, Alfonso Brenlla, Zeynep Cansu Uretmen Kagiali, Marie-José Blouin, Javier A. Tello, Annette G. Beck-Sickinger, Martin J. Lohse, Patrick Scheerer, Michel Bouvier, Peter McCormick, Paolo Annibale, Heike Biebermann   +15 more
doaj   +2 more sources

Dimerization of melanocortin 4 receptor controls puberty onset and body size polymorphism [PDF]

Frontiers in Endocrinology, 2023
Xiphophorus fish exhibit a clear phenotypic polymorphism in puberty onset and reproductive strategies of males. In X. nigrensis and X. multilineatus, puberty onset is genetically determined and linked to a melanocortin 4 receptor (Mc4r) polymorphism of ...
Ruiqi Liu, Ruiqi Liu, Mike Friedrich, Katherina Hemmen, Kerstin Jansen, Mateus C. Adolfi, Manfred Schartl, Manfred Schartl, Katrin G. Heinze   +8 more
doaj   +2 more sources

Ring finger protein 11 inhibits melanocortin 3 and 4 receptor signaling [PDF]

Frontiers in Endocrinology, 2016
Intact melanocortin signaling via the G protein-coupled receptors (GPCRs) melanocortin receptor 4 (MC4R) and melanocortin receptor 3 (MC3R) is crucial for body weight maintenance.
Anne Müller, Lars Niederstadt, Wenke Jonas, Wenke Jonas, Chun-Xia Yi, Franziska Meyer, Petra Wiedmer, Jana Fischer, Carsten Grötzinger, Annette Schürmann, Annette Schürmann, Matthias Tschöp, Matthias Tschöp, Gunnar Kleinau, Annette Grüters, Heiko Krude, Heike Biebermann   +16 more
doaj   +8 more sources

Structure elucidation of a human melanocortin-4 receptor specific orthosteric nanobody agonist [PDF]

Nature Communications
The melanocortin receptor 4 (MC4R) belongs to the melanocortin receptor family of G-protein coupled receptors and is a key switch in the leptin-melanocortin molecular axis that controls hunger and satiety.
Thomas Fontaine, Andreas Busch, Toon Laeremans, Stéphane De Cesco, Yi-Lynn Liang, Veli-Pekka Jaakola, Zara Sands, Sarah Triest, Simonas Masiulis, Lies Dekeyzer, Noor Samyn, Nicolas Loeys, Lisa Perneel, Melanie Debaere, Murielle Martini, Charlotte Vantieghem, Richa Virmani, Kamila Skieterska, Stephanie Staelens, Rosa Barroco, Maarten Van Roy, Christel Menet   +21 more
doaj   +2 more sources

Targeting melanocortin 4 receptor to treat sleep-disordered breathing in mice [PDF]

The Journal of Clinical Investigation
Weight loss medications are emerging candidates for pharmacotherapy of sleep-disordered breathing (SDB). A melanocortin 4 receptor (MC4R) agonist, setmelanotide (Set), is used to treat obesity caused by abnormal melanocortin and leptin signaling.
Mateus R. Amorim, Noah R. Williams, O. Aung, Melanie Alexis Ruiz, Frederick Anokye-Danso, Junia L. de Deus, Jiali Xiong, Olga Dergacheva, Shannon Bevans-Fonti, Sean M. Lee, Jeffrey S. Berger, Mark N. Wu, Rexford S. Ahima, David Mendelowitz, Vsevolod Y. Polotsky   +14 more
doaj   +2 more sources

Binding, Thermodynamics, and Selectivity of a Non-peptide Antagonist to the Melanocortin-4 Receptor [PDF]

Frontiers in Pharmacology, 2018
The melanocortin-4 receptor (MC4R) is a potential drug target for treatment of obesity, anxiety, depression, and sexual dysfunction. Crystal structures for MC4R are not yet available, which has hindered successful structure-based drug design.
Noureldin Saleh, Noureldin Saleh, Gunnar Kleinau, Gunnar Kleinau, Nicolas Heyder, Nicolas Heyder, Timothy Clark, Peter W. Hildebrand, Peter W. Hildebrand, Peter W. Hildebrand, Patrick Scheerer, Patrick Scheerer   +11 more
doaj   +4 more sources

Melanocortin 4 receptor signaling in Sim1 neurons permits sexual receptivity in female mice [PDF]

Frontiers in Endocrinology, 2023
IntroductionFemale sexual dysfunction affects approximately 40% of women in the United States, yet few therapeutic options exist for these patients. The melanocortin system is a new treatment target for hypoactive sexual desire disorder (HSDD), but the ...
Erin A. Semple, Mitchell T. Harberson, Baijie Xu, Rebecca Rashleigh, Tori L. Cartwright, Jessica J. Braun, Amy C. Custer, Chen Liu, Jennifer W. Hill, Jennifer W. Hill   +9 more
doaj   +2 more sources

Regulation of lean mass, bone mass, and exercise tolerance by the central melanocortin system. [PDF]

PLoS ONE, 2012
Signaling via the type 4-melanocortin receptor (MC4R) is an important determinant of body weight in mice and humans, where loss of function mutations lead to significant obesity.
Theodore P Braun, Benjamin Orwoll, Xinxia Zhu, Peter R Levasseur, Marek Szumowski, My Linh T Nguyen, Mary L Bouxsein, Robert F Klein, Daniel L Marks   +8 more
doaj   +5 more sources

CREB coactivator CRTC1 in melanocortin‐4 receptor‐expressing cells regulate dietary fat intake [PDF]

FASEB BioAdvances
Cyclic adenosine monophosphate‐response element‐binding protein‐1‐regulated transcription coactivator‐1 (CRTC1), a cytoplasmic coactivator that translocates to the nucleus in response to cAMP, is associated with obesity. We previously reported that CRTC1
Shigenobu Matsumura, Miyu Fujisawa, Mizuki Fujiwara, Houko Okayama, Miona Marutani, Eri Nousou, Tsutomu Sasaki, Naoki Harada   +7 more
doaj   +2 more sources