Results 41 to 50 of about 60,346 (220)

Charge Characteristics of Agouti-Related Protein Implicate Potent Involvement of Heparan Sulfate Proteoglycans in Metabolic Function. [PDF]

, 2019
The endogenous melanocortin peptide agouti-related protein (AgRP) plays a well-known role in foraging, but its contribution to metabolic regulation is less understood.
Chen, Jihuan, Chen, Valerie, Hoang, Ivy, Kawamura, Tomoya, McBride, Ryan, Millhauser, Glenn L, Repunte-Canonigo, Vez, Sanna, Pietro Paolo, Wong, Ashley Tess, Yang, Yang   +9 more
core   +1 more source

Melanocortin 4 receptors switch reward to aversion [PDF]

Journal of Clinical Investigation, 2018
The ability to recognize and avoid noxious stimuli is essential for survival. The factors that determine whether a given stimulus is considered positive or negative are complex and not fully understood. In this issue of the JCI, Klawonn and colleagues demonstrate that melanocortin 4 receptor (MC4R) signaling is critical for proper responses to negative
Alexandra G, DiFeliceantonio, Paul J, Kenny   +1 more
openaire   +2 more sources

Melanocortin Receptor Accessory Protein 2-Induced Adrenocorticotropic Hormone Response of Human Melanocortin 4 Receptor [PDF]

Journal of the Endocrine Society, 2018
Melanocortin 4 receptor (MC4R), a canonical melanocyte-stimulating hormone receptor, is the main responsible for monogenic obesity in humans. Previous studies in fish and avian species showed that MC4R becomes an ACTH receptor after interaction with the melanocortin receptor accessory protein 2 (MRAP2).
Lucia Soletto, Sergio Hernández-Balfagó, Ana Rocha, Patrick Scheerer, Gunnar Kleinau, José Miguel Cerdá-Reverter   +5 more
openaire   +3 more sources

MC4R gene polymorphism and its association with meat traits of Karachai sheep grown in Russian Federation

Journal of Applied Animal Research, 2021
This paper presents the results on the study of melanocortin-4 receptor (MC4R) gene polymorphisms in sheep of the Karachai breed. AA, AG, and GG genotypes were determined to have allele frequencies of 47%, 37%, and 16%, respectively, indicating that ...
Ivan Fiodorovich Gorlov, Nadezhda Vasilievna Shirokova, Elena Yurievna Anisimova, Marina Ivanovna Slozhenkina, Yuriy Anatolievich Kolosov, Arkadiy Kanurovich Natyrov, Anatoliy Yurievich Kolosov, Natalia Ivanovna Mosolova, Maria Anatolievna Kolosova, Timur Tazretovich Tarchokov, Aleksandr Anatolievich Mosolov, Daria Aleksandrovna Mosolova, Ekaterina Vladimirovna Karpenko   +12 more
doaj   +1 more source

Peripheral actions and direct central–local communications of melanocortin 4 receptor signaling

Journal of Sport and Health Science, 2023
Melanocortin 4 receptor (MC4R), the most important monogenetic cause of human metabolic disorders, has been of great interest to many researchers in the field of energy homeostasis and public health.
Lei Li, Jinye Liang, Cong Zhang, Tiemin Liu, Chao Zhang   +4 more
doaj   +1 more source

Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity. [PDF]

, 2018
Most monogenic cases of obesity in humans have been linked to mutations in genes encoding members of the leptin-melanocortin pathway. Specifically, mutations in MC4R, the melanocortin-4 receptor gene, account for 3-5% of all severe obesity cases in ...
A Hinney, A Marley, A Shalata, Aaron Marley, Adelaide A. Bernard, AS Garfield, BA Ersoy, Baran A. Ersoy, C Lubrano-Berthelier, C Lubrano-Berthelier, C Vaisse, C Vaisse, C Vaisse, Christian Vaisse, D Huszar, E Stergiakouli, F Hildebrandt, GA Bishop, GJ Morton, H Fenselau, JA Green, Jacqueline E. Siljee, Jeremy F. Reiter, JF Reiter, JR Davenport, KC Corbit, L Wu, M Calton, Mark Von Zastrow, MJ Krashes, N Balthasar, NF Berbari, P Aanstad, P Acs, SC Goetz, Sumei Zhang, Y Bromberg, Yi Wang, Z Wang   +38 more
core   +1 more source

Setmelanotide, a Novel, Selective Melanocortin Receptor-4 Agonist Exerts Anti-inflammatory Actions in Astrocytes and Promotes an Anti-inflammatory Macrophage Phenotype

Frontiers in Immunology, 2019
To date, available treatment strategies for multiple sclerosis (MS) are ineffective in preventing or reversing progressive neurologic deterioration, creating a high, and unmet medical need. One potential way to fight MS may be by limiting the detrimental
Alwin Kamermans, Tom Verhoeven, Bert van het Hof, Jasper J. Koning, Lauri Borghuis, Maarten Witte, Jack van Horssen, Helga E. de Vries, Merel Rijnsburger   +8 more
doaj   +1 more source

Melanocortin 4 receptor distribution in the human hypothalamus [PDF]

European Journal of Endocrinology, 2013
ObjectiveThe melanocortin 4 receptor (MC4R) is an essential regulator of energy homeostasis and metabolism, andMC4Rmutations represent the most prevalent monogenetic cause of obesity in humans known to date. Hypothalamic MC4Rs in rodents are well characterized in neuroanatomical and functional terms, but their expression pattern in the human ...
Siljee, J.E., Unmehopa, U.A., Kalsbeek, A., Swaab, D.F., Fliers, E., Alkemade, A.   +5 more
openaire   +6 more sources

Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency

Molecular Metabolism, 2017
Objective: Pro-opiomelanocortin (POMC)-derived peptides act on neurons expressing the Melanocortin 4 receptor (MC4R) to reduce body weight. Setmelanotide is a highly potent MC4R agonist that leads to weight loss in diet-induced obese animals and in obese
Tinh-Hai Collet, Béatrice Dubern, Jacek Mokrosinski, Hillori Connors, Julia M. Keogh, Edson Mendes de Oliveira, Elana Henning, Christine Poitou-Bernert, Jean-Michel Oppert, Patrick Tounian, Florence Marchelli, Rohia Alili, Johanne Le Beyec, Dominique Pépin, Jean-Marc Lacorte, Andrew Gottesdiener, Rebecca Bounds, Shubh Sharma, Cathy Folster, Bart Henderson, Stephen O'Rahilly, Elizabeth Stoner, Keith Gottesdiener, Brandon L. Panaro, Roger D. Cone, Karine Clément, I. Sadaf Farooqi, Lex H.T. Van der Ploeg   +27 more
doaj   +1 more source

Melanotan-II reverses autistic features in a maternal immune activation mouse model of autism [PDF]

, 2019
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by impaired social interactions, difficulty with communication, and repetitive behavior patterns. In humans affected by ASD, there is a male pre-disposition towards the
Gould, Georgianna G, Lang, Jordan, Mazarati, Andrey, Medel-Matus, Jesus-Servando, Minakova, Elena, Reynolds, Ashley, Sankar, Raman, Shin, Don   +7 more
core   +2 more sources