Results 41 to 50 of about 46,881 (189)

Inhibition of the central melanocortin system decreases brown adipose tissue activity[S]

Journal of Lipid Research, 2014
The melanocortin system is an important regulator of energy balance, and melanocortin 4 receptor (MC4R) deficiency is the most common monogenic cause of obesity.
Sander Kooijman, Mariëtte R. Boon, Edwin T. Parlevliet, Janine J. Geerling, Vera van de Pol, Johannes A. Romijn, Louis M. Havekes, Illiana Meurs, Patrick C.N. Rensen   +8 more
doaj   +1 more source

Melanocortin 4 Receptor and Dopamine D2 Receptor Expression in Brain Areas Involved in Food Intake [PDF]

Endocrinology and Metabolism, 2015
BackgroundThe melanocortin 4 receptor (MC4R) is involved in the regulation of homeostatic energy balance by the hypothalamus. Recent reports showed that MC4R can also control the motivation for food in association with a brain reward system, such as ...
Ye Ran Yoon, Ja-Hyun Baik
doaj   +1 more source

Reversion of MRAP2 Protein Sequence Generates a Functional Novel Pharmacological Modulator for MC4R Signaling

Biology, 2022
As a member of the melanocortin receptor family, melanocortin 4 receptor (MC4R) plays a critical role in regulating energy homeostasis and feeding behavior, and has been proven as a promising therapeutic target for treating severe obesity syndrome ...
Jing Xu, Meng Wang, Yanbin Fu, Cong Zhang, Zhe Kuang, Shan Bian, Rui Wan, Shen Qu, Chao Zhang   +8 more
doaj   +1 more source

Effects of Melanocortin Receptor Activation and Blockade on Ethanol Intake: A Possible Role for the Melanocortin-4 Receptor [PDF]

Alcoholism: Clinical & Experimental Research, 2005
The melanocortin (MC) system is composed of peptides that are cleaved from the polypeptide precursor proopiomelanocortin. A growing body of literature suggests that the MC system modulates neurobiological responses to drugs of abuse. Because ethanol has direct effects on central proopiomelanocortin activity, it is possible that MC neuropeptides ...
Montserrat, Navarro, Inmaculada, Cubero, Airu S, Chen, Howard Y, Chen, Darin J, Knapp, George R, Breese, Donald J, Marsh, Todd E, Thiele   +7 more
openaire   +2 more sources

Health‐Related Quality of Life, Everyday Executive Functioning, and Eating Behavior in Adults With Bardet–Biedl Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Bardet–Biedl syndrome (BBS) is a rare genetic condition with a broad phenotypic spectrum. Knowledge about quality of life, executive functioning, and eating behavior in adults with BBS remains limited. This study aimed to assess health‐related quality of life (HRQoL), everyday executive functioning, and eating behavior in adults with BBS and ...
Cecilie Fremstad Rustad, Charlotte von der Lippe, Hilde Nordgarden, Jeanette Ullmann Miller, Mina Susanne Weedon‐Fekjær, Ragnheidur Bragadottir, Solrun Sigurdardottir   +6 more
wiley   +1 more source

Pharmacological Evaluation of Melanocortin 2 Receptor Accessory Protein 2 on Axolotl Neural Melanocortin Signaling

Frontiers in Endocrinology, 2022
The Melanocortin-3 receptor (MC3R) and Melanocortin-4 receptor (MC4R), two members of the key hypothalamic neuropeptide signaling, function as complex mediators to control the central appetitive and energy homeostasis.
Xiaozhu Wang, Song Xue, Xiaowei Lei, Wenqi Song, Lei Li, Xuan Li, Yanbin Fu, Cong Zhang, Hailin Zhang, Hailin Zhang, Yao Luo, Meng Wang, Gufa Lin, Gufa Lin, Chao Zhang, Jing Guo   +15 more
doaj   +1 more source

Streamlining Diagnosis of Bardet–Biedl Syndrome: New Diagnostic Algorithm With Updated Criteria

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Considerable advances have been made in our understanding of Bardet–Biedl syndrome (BBS), particularly in its core clinical features and molecular genetics, warranting an update to the existing diagnostic criteria framework. Using a rigorous, evidence‐based, and consensus‐driven process, a multidisciplinary group of international experts and ...
Jeremy J. Pomeroy, Jesse Richards, Brooke R. Sweeney, Seema Kumar, Katie E. Queen, Joshua Zaritsky, Carl H. Cramer, Elias I. Traboulsi, Brittni A. Scruggs, Erica E. Davis, Ekaterina Keifer, Emma McGibbon, Timothy Ogden, Bendert De Graaf, Tonia Hymers, Elizabeth Forsythe, Philip Beales   +16 more
wiley   +1 more source

Loss of the melanocortin-4 receptor in mice causes dilated cardiomyopathy

eLife, 2017
Haploinsufficiency of the melanocortin-4 receptor, the most common monogenetic obesity syndrome in humans, is associated with a reduction in autonomic tone, bradycardia, and incidence of obesity-associated hypertension.
Michael J Litt, G Donald Okoye, Daniel Lark, Isin Cakir, Christy Moore, Mary C Barber, James Atkinson, Josh Fessel, Javid Moslehi, Roger D Cone   +9 more
doaj   +1 more source

The Melanocortin-4 Receptor: Physiology, Pharmacology, and Pathophysiology [PDF]

Endocrine Reviews, 2010
The melanocortin-4 receptor (MC4R) was cloned in 1993 by degenerate PCR; however, its function was unknown. Subsequent studies suggest that the MC4R might be involved in regulating energy homeostasis. This hypothesis was confirmed in 1997 by a series of seminal studies in mice. In 1998, human genetic studies demonstrated that mutations in the MC4R gene
openaire   +2 more sources

Development of a genetically encoded melanocortin sensor for high sensitivity in vivo imaging

Molecular Metabolism
Objective: The central melanocortin system, composed of peptides derived from pro-opiomelanocortin (POMC) such as the melanocyte-stimulating hormones (α-, β-, γ-MSH) and melanocortin 4 receptors (MC4R), along with the agouti-related protein (AgRP), plays
Yoon Namkung, Tal Slutzki, Joao Pedroso, Xiaohong Liu, Paul V. Sabatini, Maia V. Kokoeva, Stéphane A. Laporte   +6 more
doaj   +1 more source