Results 31 to 40 of about 46,881 (189)

Remapping the Synthetic Landscape of α‐Tertiary Alkylamines via Dual‐Functional Catechol

Angewandte Chemie, EarlyView.
A three‐component assembly strategy has been developed for the modular synthesis of hindered α‐tertiary aliphatic amines from readily available precursors through unlocking the dual role of catechol. The practicality of this methodology has been demonstrated in over 90 examples, including compounds that are otherwise difficult to access, along with ...
Chen‐Yan Cai, Yuzuru Kanda, Tian Qin
wiley   +2 more sources

MC4R gene polymorphism and its association with meat traits of Karachai sheep grown in Russian Federation

Journal of Applied Animal Research, 2021
This paper presents the results on the study of melanocortin-4 receptor (MC4R) gene polymorphisms in sheep of the Karachai breed. AA, AG, and GG genotypes were determined to have allele frequencies of 47%, 37%, and 16%, respectively, indicating that ...
Ivan Fiodorovich Gorlov, Nadezhda Vasilievna Shirokova, Elena Yurievna Anisimova, Marina Ivanovna Slozhenkina, Yuriy Anatolievich Kolosov, Arkadiy Kanurovich Natyrov, Anatoliy Yurievich Kolosov, Natalia Ivanovna Mosolova, Maria Anatolievna Kolosova, Timur Tazretovich Tarchokov, Aleksandr Anatolievich Mosolov, Daria Aleksandrovna Mosolova, Ekaterina Vladimirovna Karpenko   +12 more
doaj   +1 more source

Peripheral actions and direct central–local communications of melanocortin 4 receptor signaling

Journal of Sport and Health Science, 2023
Melanocortin 4 receptor (MC4R), the most important monogenetic cause of human metabolic disorders, has been of great interest to many researchers in the field of energy homeostasis and public health.
Lei Li, Jinye Liang, Cong Zhang, Tiemin Liu, Chao Zhang   +4 more
doaj   +1 more source

Setmelanotide, a Novel, Selective Melanocortin Receptor-4 Agonist Exerts Anti-inflammatory Actions in Astrocytes and Promotes an Anti-inflammatory Macrophage Phenotype

Frontiers in Immunology, 2019
To date, available treatment strategies for multiple sclerosis (MS) are ineffective in preventing or reversing progressive neurologic deterioration, creating a high, and unmet medical need. One potential way to fight MS may be by limiting the detrimental
Alwin Kamermans, Tom Verhoeven, Bert van het Hof, Jasper J. Koning, Lauri Borghuis, Maarten Witte, Jack van Horssen, Helga E. de Vries, Merel Rijnsburger   +8 more
doaj   +1 more source

Melanocortin-4 receptor–regulated energy homeostasis [PDF]

Nature Neuroscience, 2016
The melanocortin system provides a conceptual blueprint for the central control of energetic state. Defined by four principal molecular components--two antagonistically acting ligands and two cognate receptors--this phylogenetically conserved system serves as a prototype for hierarchical energy balance regulation.
Michael J, Krashes, Bradford B, Lowell, Alastair S, Garfield   +2 more
openaire   +2 more sources

Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency

Molecular Metabolism, 2017
Objective: Pro-opiomelanocortin (POMC)-derived peptides act on neurons expressing the Melanocortin 4 receptor (MC4R) to reduce body weight. Setmelanotide is a highly potent MC4R agonist that leads to weight loss in diet-induced obese animals and in obese
Tinh-Hai Collet, Béatrice Dubern, Jacek Mokrosinski, Hillori Connors, Julia M. Keogh, Edson Mendes de Oliveira, Elana Henning, Christine Poitou-Bernert, Jean-Michel Oppert, Patrick Tounian, Florence Marchelli, Rohia Alili, Johanne Le Beyec, Dominique Pépin, Jean-Marc Lacorte, Andrew Gottesdiener, Rebecca Bounds, Shubh Sharma, Cathy Folster, Bart Henderson, Stephen O'Rahilly, Elizabeth Stoner, Keith Gottesdiener, Brandon L. Panaro, Roger D. Cone, Karine Clément, I. Sadaf Farooqi, Lex H.T. Van der Ploeg   +27 more
doaj   +1 more source

Melanocortin 4 receptors switch reward to aversion [PDF]

Journal of Clinical Investigation, 2018
The ability to recognize and avoid noxious stimuli is essential for survival. The factors that determine whether a given stimulus is considered positive or negative are complex and not fully understood. In this issue of the JCI, Klawonn and colleagues demonstrate that melanocortin 4 receptor (MC4R) signaling is critical for proper responses to negative
Alexandra G, DiFeliceantonio, Paul J, Kenny   +1 more
openaire   +2 more sources

The melanocortin receptors as targets for general obesity: contextualizing clinical failures and analyzing future perspectives

Frontiers in Endocrinology
The melanocortin system is a genetically conserved and clinically validated target for the treatment of obesity. Hundreds of studies establish the role of the melanocortin receptors, particularly the melanocortin-4 receptor, in food intake, weight ...
Claudia R. Prindle, Thomas L. Bennett, Benjamin H. Rajewski, Kade J. Kelley, Anna C. Impastato, Russell Potterfield, Daniel L. Marks, Jordan Y. Delev   +7 more
doaj   +1 more source

Ring finger protein 11 inhibits melanocortin 3 and 4 receptor signaling

Frontiers in Endocrinology, 2016
Intact melanocortin signaling via the G protein-coupled receptors (GPCRs) melanocortin receptor 4 (MC4R) and melanocortin receptor 3 (MC3R) is crucial for body weight maintenance.
Anne Müller, Lars Niederstadt, Wenke Jonas, Wenke Jonas, Chun-Xia Yi, Franziska Meyer, Petra Wiedmer, Jana Fischer, Carsten Grötzinger, Annette Schürmann, Annette Schürmann, Matthias Tschöp, Matthias Tschöp, Gunnar Kleinau, Annette Grüters, Heiko Krude, Heike Biebermann   +16 more
doaj   +1 more source

Functional Characterization of the Internal Symmetry of MRAP2 Antiparallel Homodimer

Frontiers in Endocrinology, 2021
The melanocortin receptors are defined as a series of vital pharmaceutical targets to regulate neuronal appetite and maintain controllable body weight for mammals and teleosts.
Meng Wang, Linyu Pi, Xiaowei Lei, Lei Li, Jing Xu, Zhe Kuang, Cong Zhang, Liang Li, Chao Zhang   +8 more
doaj   +1 more source