Results 11 to 20 of about 60,346 (220)
Anti-melanocortin-4 receptor autoantibodies in obesity [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2009 Background: The melanocortin-4 receptor (MC4R) is part of an important pathway regulating energy balance. Here we report the existence of autoantibodies (autoAbs) against the MC4R in sera of obese patients.
Bekel, A. +9 more
core +8 more sources
Molecular Metabolism, 2020 Objective: Histaminergic neurons of the tuberomammillary nucleus (TMN) are wake-promoting and contribute to the regulation of energy homeostasis. Evidence indicates that melanocortin 4 receptors (MC4R) are expressed within the TMN.
Natalie J. Michael +7 more
doaj +3 more sources
The Melanocortin-4 Receptor: Physiology, Pharmacology, and Pathophysiology [PDF]
Endocrine Reviews, 2010 The melanocortin-4 receptor (MC4R) was cloned in 1993 by degenerate PCR; however, its function was unknown. Subsequent studies suggest that the MC4R might be involved in regulating energy homeostasis. This hypothesis was confirmed in 1997 by a series of seminal studies in mice. In 1998, human genetic studies demonstrated that mutations in the MC4R gene
Ya-Xiong Tao
openaire +4 more sources
Astrocytes: New Targets of Melanocortin 4 Receptor Actions [PDF]
Journal of Molecular Endocrinology, 2013 Astrocytes exert a wide variety of functions with paramount importance in brain physiology. After injury or infection, astrocytes become reactive and they respond by producing a variety of inflammatory mediators that help maintain brain homeostasis. Loss
Carniglia, Lila +4 more
core +5 more sources
Proopiomelanocortin Deficiency Treated with a Melanocortin-4 Receptor Agonist
New England Journal of Medicine, 2016 Patients with rare defects in the gene encoding proopiomelanocortin (POMC) have extreme early-onset obesity, hyperphagia, hypopigmentation, and hypocortisolism, resulting from the lack of the proopiomelanocortin-derived peptides melanocyte-stimulating hormone and corticotropin. In such patients, adrenal insufficiency must be treated with hydrocortisone
Peter, Kühnen +9 more
openaire +4 more sources
Melanocortin-4 receptor and leptin as genes for the selection of superior Madrasin cattle [PDF]
Veterinary World, 2021 Background and Aim: The genetic improvement of cattle through livestock section is based on quantitative, qualitative, and molecular characteristics. This study examined polymorphisms of the melanocortin-4 receptor (MC4R) and leptin genes as a reference ...
Budi Utomo +3 more
doaj +1 more source
Melanocortin 4 receptor mutation in obesity. [PDF]
World J Exp MedObesity is increasingly prevalent worldwide, with genetic factors contributing to its development. The hypothalamic leptin-melanocortin pathway is central to the regulation of appetite and weight; leptin activates the proopiomelanocortin neurons, leading to the production of melanocortin peptides; these in turn act on melanocortin 4 receptors (MC4R ...
Sridhar GR, Gumpeny L.
europepmc +3 more sources
Genetic obesity: an update with emerging therapeutic approaches [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2022 Based on the genetic contribution, childhood obesity can be classified into 3 groups: common polygenic obesity, syndromic obesity, and monogenic obesity.
Young Bae Sohn
doaj +1 more source
Biomolecules, 2022 The neural melanocortin receptors (MCRs), melanocortin-3 and -4 receptors (MC3R and MC4R), play essential non-redundant roles in the regulation of energy homeostasis. Interaction of neural MCRs and melanocortin-2 receptor accessory proteins (MRAPs, MRAP1
Ren-Lei Ji, Ya-Xiong Tao
doaj +1 more source
Biomolecules, 2022 The neural melanocortin receptors (MCRs), melanocortin-3 and -4 receptors (MC3R and MC4R), have crucial roles in regulating energy homeostasis. The melanocortin-2 receptor accessory proteins (MRAPs, MRAP1 and MRAP2) have been shown to regulate neural ...
Ren-Lei Ji +2 more
doaj +1 more source