Results 11 to 20 of about 46,881 (189)

Current Mechanistic and Pharmacodynamic Understanding of Melanocortin-4 Receptor Activation

Molecules, 2019
In this work we summarize our understanding of melanocortin 4 receptor (MC4R) pathway activation, aiming to define a safe and effective therapeutic targeting strategy for the MC4R.
Shubh Sharma, Alastair S. Garfield, Bhavik Shah, Patrick Kleyn, Ilia Ichetovkin, Ida Hatoum Moeller, William R. Mowrey, Lex H.T. Van der Ploeg   +7 more
doaj   +3 more sources

CREB coactivator CRTC1 in melanocortin‐4 receptor‐expressing cells regulate dietary fat intake [PDF]

FASEB BioAdvances
Cyclic adenosine monophosphate‐response element‐binding protein‐1‐regulated transcription coactivator‐1 (CRTC1), a cytoplasmic coactivator that translocates to the nucleus in response to cAMP, is associated with obesity. We previously reported that CRTC1
Shigenobu Matsumura, Miyu Fujisawa, Mizuki Fujiwara, Houko Okayama, Miona Marutani, Eri Nousou, Tsutomu Sasaki, Naoki Harada   +7 more
doaj   +2 more sources

Melanocortin-4 receptor and leptin as genes for the selection of superior Madrasin cattle [PDF]

Veterinary World, 2021
Background and Aim: The genetic improvement of cattle through livestock section is based on quantitative, qualitative, and molecular characteristics. This study examined polymorphisms of the melanocortin-4 receptor (MC4R) and leptin genes as a reference ...
Budi Utomo, Rimayanti Rimayanti, Indah Norma Triana, Amaq Fadholly   +3 more
doaj   +1 more source

Genetic obesity: an update with emerging therapeutic approaches [PDF]

Annals of Pediatric Endocrinology & Metabolism, 2022
Based on the genetic contribution, childhood obesity can be classified into 3 groups: common polygenic obesity, syndromic obesity, and monogenic obesity.
Young Bae Sohn
doaj   +1 more source

Melanocortin 4 Receptor Becomes an ACTH Receptor by Coexpression of Melanocortin Receptor Accessory Protein 2 [PDF]

Molecular Endocrinology, 2013
Melanocortin 2 receptor (MC2R) is the only canonical ACTH receptor. Its functional expression requires the presence of an accessory protein, known as melanocortin receptor 2 accessory protein 1 (MRAP1). The vertebrate genome exhibits a paralogue gene called MRAP2, which is duplicated in zebrafish (MRAP2a and MRAP2b), although its function remains ...
Agulleiro Gozalbo, Maria Josep, Cortés, Raúl, Fernández-Durán, Begoña, Navarro, Sandra, Guillot, Raúl, Meimaridou, E., Clark, A. J. L., Cerdá-Reverter, José Miguel   +7 more
openaire   +3 more sources

The complicated clinical course in a case of atypical lipodystrophy after development of neutralizing antibody to metreleptin: treatment with setmelanotide

Endocrinology, Diabetes & Metabolism Case Reports, 2020
A patient with atypical partial lipodystrophy who had a transient initial response to metreleptin experienced acute worsening of her metabolic state when neutralizing antibodies against metreleptin appeared.
Baris Akinci, Rasimcan Meral, Diana Rus, Rita Hench, Adam H Neidert, Frank DiPaola, Maria Westerhoff, Simeon I Taylor, Elif A Oral   +8 more
doaj   +1 more source

Melanocortin 4 receptor distribution in the human hypothalamus [PDF]

European Journal of Endocrinology, 2013
ObjectiveThe melanocortin 4 receptor (MC4R) is an essential regulator of energy homeostasis and metabolism, andMC4Rmutations represent the most prevalent monogenetic cause of obesity in humans known to date. Hypothalamic MC4Rs in rodents are well characterized in neuroanatomical and functional terms, but their expression pattern in the human ...
Siljee, J.E., Unmehopa, U.A., Kalsbeek, A., Swaab, D.F., Fliers, E., Alkemade, A.   +5 more
openaire   +6 more sources

Melanocortin Pathways: Suppressed and Stimulated Melanocortin-4 Receptor (MC4R)

Physiological Research, 2020
Leptin-melanocortin pathway plays an essential role in the body weight regulation. Enhanced melanocortin signaling in the hypothalamus results in both decreased food intake and increased energy expenditure. The discovery of monogenic obesities with dysfunction of melanocortin-4 receptor (MC4R) greatly contributed to understanding of energy balance ...
V, Hainer, I, Aldhoon Hainerová, M, Kunešová, R, Taxová Braunerová, H, Zamrazilová, B, Bendlová   +5 more
openaire   +2 more sources

Melanocortin-4 Receptors (MC4R)

AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh, 2023
Melanocortin 4 Receptors (MC4R) merupakan turunan senyawa G protein coupled-receptors (GPCRs). MC4R berperan dalam homeostasis energi, fungsi kardiovaskular, dan sistem reproduksi. Gen MC4R ini menyandi sekitar 332 asam amino dan terkespresi pada hipotalamus. MC4R salah satu protein transmembran dengan memiliki tujuh subtipe protein.
Liza Arieska Saiful, Nuraiza Meutia
openaire   +1 more source

Anti-Melanocortin-4 Receptor Autoantibodies in Obesity [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2009
The melanocortin-4 receptor (MC4R) is part of an important pathway regulating energy balance. Here we report the existence of autoantibodies (autoAbs) against the MC4R in sera of obese patients.The autoAbs were detected after screening of 216 patients' sera by using direct and inhibition ELISA with an N-terminal sequence of the MC4R.
Peter, Jean-Christophe, Bekel, Akkiz, Lecourt, Anne-Catherine, Zipfel, Géraldine, Eftekhari, Pierre, Nesslinger, Maya, Breidert, Matthias, Muller, Sylviane, Kessler, Laurence, Hofbauer, Karl G   +9 more
openaire   +5 more sources