Targeting the melanocortin receptor system for anti-stroke therapy [PDF]
, 2011 The melanocortin receptors are a subfamily of G-protein-coupled, rhodopsin-like receptors that are rapidly being acknowledged as an extremely promising target for pharmacological intervention in a variety of different inflammatory pathologies, including ...
Smith, H.K. +5 more
core +1 more source
Functional Characterization of the Internal Symmetry of MRAP2 Antiparallel Homodimer
Frontiers in Endocrinology, 2021 The melanocortin receptors are defined as a series of vital pharmaceutical targets to regulate neuronal appetite and maintain controllable body weight for mammals and teleosts.
Meng Wang +8 more
doaj +1 more source
Melanocortin-4 Receptors (MC4R) [PDF]
, 2023 Melanocortin 4 Receptors (MC4R) merupakan turunan senyawa G protein coupled-receptors (GPCRs). MC4R berperan dalam homeostasis energi, fungsi kardiovaskular, dan sistem reproduksi.
Meutia, Nuraiza, Saiful, Liza Arieska
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American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Bardet–Biedl syndrome (BBS) is a rare genetic condition with a broad phenotypic spectrum. Knowledge about quality of life, executive functioning, and eating behavior in adults with BBS remains limited. This study aimed to assess health‐related quality of life (HRQoL), everyday executive functioning, and eating behavior in adults with BBS and ...
Cecilie Fremstad Rustad +6 more
wiley +1 more source
5-ht inhibition of rat insulin 2 promoter cre recombinase transgene and proopiomelanocortin neuron excitability in the mouse arcuate nucleus [PDF]
, 2009 A number of anti-obesity agents have been developed that enhance hypothalamic 5-HT transmission. Various studies have demonstrated that arcuate neurons, which express proopiomelanocortin peptides (POMC neurons), and neuropeptide Y with agouti-related ...
Smith, M. A. +9 more
core +1 more source
Streamlining Diagnosis of Bardet–Biedl Syndrome: New Diagnostic Algorithm With Updated Criteria
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Considerable advances have been made in our understanding of Bardet–Biedl syndrome (BBS), particularly in its core clinical features and molecular genetics, warranting an update to the existing diagnostic criteria framework. Using a rigorous, evidence‐based, and consensus‐driven process, a multidisciplinary group of international experts and ...
Jeremy J. Pomeroy +16 more
wiley +1 more source
Translational research in rheumatoid arthritis: Exploiting melanocortin receptors [PDF]
, 2014 The copyright of this thesis rests with the author and no quotation from it or information derived from it may be published without the prior written consent of the authorRheumatoid arthritis (RA) is a chronic inflammatory disease affecting 1% of the ...
Ahmed, Tazeen Jahan
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Antifibrotic and Anti-Inflammatory Actions of α-Melanocytic Hormone: New Roles for an Old Player
Pharmaceuticals, 2021 The melanocortin system encompasses melanocortin peptides, five receptors, and two endogenous antagonists. Besides pigmentary effects generated by α-Melanocytic Hormone (α-MSH), new physiologic roles in sexual activity, exocrine secretion, energy ...
Roshan Dinparastisaleh, Mehdi Mirsaeidi
doaj +1 more source
Phenotypic characteristics of familial glucocorticoid deficiency (FGD) type 1 and 2 [PDF]
, 2010 Context: Familial glucocorticoid deficiency (FGD) is a rare autosomal recessive disorder as a result of mutation in genes encoding either the ACTH receptor [melanocortin 2 receptor (MC2R)] or its accessory protein [melanocortin 2 receptor accessory ...
Metherell, LA +5 more
core +1 more source
The neuropeptide alpha-melanocyte-stimulating hormone is critically involved in the development of cytotoxic CD8+ T cells in mice and humans. [PDF]
PLoS ONE, 2010 BACKGROUND: The neuropeptide alpha-melanocyte-stimulating hormone is well known as a mediator of skin pigmentation. More recently, it has been shown that alpha-melanocyte-stimulating hormone also plays pivotal roles in energy homeostasis, sexual function,
Karin Loser +10 more
doaj +1 more source