Results 11 to 20 of about 10,319 (179)
Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency [PDF]
Molecular Metabolism, 2017 Objective: Pro-opiomelanocortin (POMC)-derived peptides act on neurons expressing the Melanocortin 4 receptor (MC4R) to reduce body weight. Setmelanotide is a highly potent MC4R agonist that leads to weight loss in diet-induced obese animals and in obese
Tinh-Hai Collet +27 more
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The effects of MC4R activation on behavioral activity in mice
Translation, 2023 Joseph Dale +2 more
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MC4R mutant mice develop ovarian teratomas [PDF]
Scientific Reports, 2021 AbstractTeratomas in mice, composed of different tissue types, are derived from primordial germ cells (PGCs) in the foetal gonads. The strongest candidate gene in the testicular teratoma locus (Ter) responsible for testicular teratoma formation was identified as mutation in Dnd1, Dnd1R178*.
Abdullah An Naser +5 more
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The Relation between Childhood Obesity and MC4R Gene and Near MC4R Polymorphisms
Gazi Medical Journal, 2020 Childhood obesity, especially in the developed countries including all over the world has an increasing prevalence. Regarding the major impact on public health perspective, childhood obesity should be monitored closely. Many researchers reported MC4R gene and near MC4R region polymorphisms to predispose monogenic obesity both in children and adults. In
Erkal, Ozgur +4 more
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Frontiers in Endocrinology, 2020 Melanocortin-4 receptor (MC4R) plays important roles in regulation of multiple physiological processes, and interaction of MC4R and melanocortin receptor accessory protein 2 (MRAP2) is suggested to play pivotal role in energy balance of vertebrates ...
Min Tao +7 more
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Peripheral actions and direct central–local communications of melanocortin 4 receptor signaling
Journal of Sport and Health Science, 2023 Melanocortin 4 receptor (MC4R), the most important monogenetic cause of human metabolic disorders, has been of great interest to many researchers in the field of energy homeostasis and public health.
Lei Li +4 more
doaj +1 more source
Cell Regeneration, 2021 Background Expression of Mc4r in peripheral organs indicates it has broader roles in organ homeostasis and regeneration. However, the expression and function of Mc4r in the mouse limb and digit has not been fully investigated.
Hanqian Xu +6 more
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Melanocortin-4 Receptors (MC4R)
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh, 2023 Melanocortin 4 Receptors (MC4R) merupakan turunan senyawa G protein coupled-receptors (GPCRs). MC4R berperan dalam homeostasis energi, fungsi kardiovaskular, dan sistem reproduksi. Gen MC4R ini menyandi sekitar 332 asam amino dan terkespresi pada hipotalamus. MC4R salah satu protein transmembran dengan memiliki tujuh subtipe protein.
Liza Arieska Saiful, Nuraiza Meutia
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Selective Survival of Sim1/MC4R Neurons in Diet-Induced Obesity
iScience, 2020 Summary: In the melanocortin pathway, melanocortin-4 receptor (MC4R) functions to control energy homeostasis. MC4R is expressed in a sub-population of Sim1 neurons (Sim1/MC4R neurons) and functions in hypothalamic paraventricular nuclei (PVN) to control ...
Eugene Nyamugenda +7 more
doaj +1 more source
Melanocortin-4 receptor mutations and polymorphisms do not affect weight loss after bariatric surgery. [PDF]
PLoS ONE, 2012 Bariatric surgery is the most effective long term weight-loss therapy for severe and morbidly obese patients. Melanocortin-4 Receptor (MC4R) mutations, the most frequent known cause of monogenic obesity, affect the regulation of energy homeostasis.
Marion Valette +5 more
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