Results 71 to 80 of about 11,016 (204)

SIGNS OF POSTEMBRYONAL DEVELOPMENT YOUNG PIGS OF DIFFERENT GENOTYPES BY MELANOCORTIN 4 (MC4R) RECEPTOR GENE AND THEIR PRODUCTIVITY

, 2022
В. І. Халак, B. V. Gutyj, О. М. Бордун, А. М. Саєнко   +3 more
openalex   +2 more sources

Targeting melanocortin 4 receptor to treat sleep-disordered breathing in mice

The Journal of Clinical Investigation
Weight loss medications are emerging candidates for pharmacotherapy of sleep-disordered breathing (SDB). A melanocortin 4 receptor (MC4R) agonist, setmelanotide (Set), is used to treat obesity caused by abnormal melanocortin and leptin signaling.
Mateus R. Amorim, Noah R. Williams, O. Aung, Melanie Alexis Ruiz, Frederick Anokye-Danso, Junia L. de Deus, Jiali Xiong, Olga Dergacheva, Shannon Bevans-Fonti, Sean M. Lee, Jeffrey S. Berger, Mark N. Wu, Rexford S. Ahima, David Mendelowitz, Vsevolod Y. Polotsky   +14 more
doaj   +1 more source

Maid gene dysfunction promotes hyperobesity via the reduction of adipose tissue inflammation in Mc4r gene-deficient mice

Scientific Reports
The onset and progression mechanisms of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) are being studied.
Kyutaro Koyama, Akira Sakamaki, Shinichi Morita, Itsuo Nagayama, Marina Kudo, Yuto Tanaka, Naruhiro Kimura, Yoshihisa Arao, Hiroyuki Abe, Kenya Kamimura, Shuji Terai   +10 more
doaj   +1 more source

Evaluation of MC4R [rs17782313, rs17700633], AGRP [rs3412352] and POMC [rs1042571] Polymorphisms with Obesity in Northern India

Oman Medical Journal, 2014
Objective: Genetic variants of the melanocortin-4 receptor gene (MC4R), agouti related protein (AGRP) and proopiomelanocortin (POMC) are reported to be associated with obesity.
Apurva Srivastava, Balraj Mittal, Jai Prakash, Varun Shanker Narain, S.M. Natu, Neena Srivastava   +5 more
doaj   +1 more source

Hypothalamic POMC neuron-specific knockout of MC4R affects insulin sensitivity by regulating Kir2.1

Molecular Medicine
Background Imbalance in energy regulation is a major cause of insulin resistance and diabetes. Melanocortin-4 receptor (MC4R) signaling at specific sites in the central nervous system has synergistic but non-overlapping functions.
Hengru Guo, Ying Xin, Saifei Wang, Xiaoning Zhang, Yanqi Ren, Bo Qiao, Hongjiang Li, Jing Wu, Xiao Hao, Lijun Xu, Yushan Yan, Haohao Zhang   +11 more
doaj   +1 more source

Evaluation of the Obesity Genes FTO and MC4R for Contribution to the Risk of Large Artery Atherosclerotic Stroke in a Chinese Population

Obesity Facts, 2016
Background: Obesity is a well-established risk factor for large artery atherosclerotic (LAA) stroke. The aim of the study was to explore whether obesity genes, such as MC4R and FTO, contribute to LAA stroke risk in the Chinese Han population.
Zhi Song, Lingling Qiu, Zhongyang Hu, Jia Liu, Ding Liu, Deren Hou   +5 more
doaj   +1 more source

Moderate voluntary exercise attenuates the metabolic syndrome in melanocortin-4 receptor-deficient rats showing central dopaminergic dysregulation

Molecular Metabolism, 2015
Objective: Melanocortin-4 receptors (MC4Rs) are highly expressed by dopamine-secreting neurons of the mesolimbic tract, but their functional role has not been fully resolved.
Silvana Obici, I. Jack Magrisso, Armen S. Ghazarian, Alireza Shirazian, Jonas R. Miller, Christine M. Loyd, Denovan P. Begg, Kimberly A. Krawczewski Carhuatanta, Michael K. Haas, Jon F. Davis, Stephen C. Woods, Darleen A. Sandoval, Randy J. Seeley, Laurie J. Goodyear, Emmanuel N. Pothos, Joram D. Mul   +15 more
doaj   +1 more source

Heterozygous versus homozygous phenotype caused by the same MC4R mutation: novel mutation affecting a large consanguineous kindred

BMC Medical Genetics, 2018
Background The hypothalamic G-protein-coupled-receptor melanocortin-4 receptor (MC4R) is a key player in the central circuit regulating energy expenditure and appetite.
Max Drabkin, Ohad S. Birk, Ruth Birk
doaj   +1 more source

Predisposition of the Common MC4R rs17782313 Female Carriers to Elevated Obesity and Interaction with Eating Habits [PDF]

, 2023
Danyel Chermon, Ruth Birk
openalex   +1 more source

MC4R Localizes at Excitatory Postsynaptic and Peri-Postsynaptic Sites of Hypothalamic Neurons in Primary Culture

Cells
The melanocortin-4 receptor (MC4R) is a G protein-coupled receptor (GPCR) that is expressed in several brain locations encompassing the hypothalamus and the brainstem, where the receptor controls several body functions, including metabolism.
Haven Griffin, Jude Hanson, Kevin D. Phelan, Giulia Baldini   +3 more
doaj   +1 more source