Results 171 to 180 of about 3,703 (248)

Engineered Pericyte‐Targeted Extracellular Vesicles Protect Against Hypoperfusion‐Induced Cognitive Impairment and Vascular Demyelination

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
Schematic illustration on a therapeutic strategy wherein engineered extracellular vesicles (EVs) are delivered intranasally and specifically target pericytes. In a model of chronic cerebral hypoperfusion (BCAS), this targeted approach preserves cerebral blood flow, reinforces blood‐brain barrier (BBB) integrity, stabilizes the neurovascular unit (NVU),
Weiwei Shen, Weishi Liu, Min Guo, Tongyao You, Yingzhe Wang, Tiansiyu Wen, Suzhen Liang, Xiaodi Xie, Yanfeng Jiang, Qiang Dong, Jin‐Tai Yu, Mei Cui   +11 more
wiley   +1 more source

X-ray analysis of complexes of carbonic anhydrase II with 1,3-oxazole-containing sulfonamide derivatives elucidates the structural basis for their exceptionally high inhibitory potency. [PDF]

Acta Crystallogr F Struct Biol Commun
Stoliarskaia MY, Borisevich SS, Myaskov EO, Shetnev AA, Korsakov MK, Nikonov OS.   +5 more
europepmc   +1 more source

Impact of Socioeconomic Disparities Among Pediatric Airway and Otology Patients on Access to Care

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 3, June 2026.
Otology patients were more likely to be referred to the specialty clinic, have fewer no shows, and attend a higher number of follow up visits despite having minimal differences in social demographics. Future study targeting follow‐up and retention for airway clinic patients is needed.
Lauren A. Gardiner, Amber D. Shaffer, Nanki Hura, Nicholas R. Oberlies, Jennifer L. McCoy, David H. Chi, Jeffrey P. Simons   +6 more
wiley   +1 more source

Fire ant-venom anaphylaxis prevalence in the general population and patients with systemic mastocytosis. [PDF]

Front Allergy
McMurray JC, Schornack BJ, Adams KE, McCoy RL, Marshall AK, Brunader JA, Maric I, Metcalfe DD, Boggs NA.   +8 more
europepmc   +1 more source

Synthesis, Photophysical Characterization, and Anticancer Evaluation of Novel Furochromene Derivatives

ChemistryOpen, Volume 15, Issue 6, June 2026.
This is the first study on novel furochromene derivatives. A series of novel furochromen derivatives, namely (2E)‐1‐(6‐hydroxy‐4,7‐dimethoxy‐1‐benzofuran‐5‐yl)‐3‐arylprop‐2‐en‐1‐ones 4a–c, were synthesized via the Knoevenagel condensation of 6‐hydroxy‐4,7‐dimethoxybenzofuran‐5‐ylethanone 2 with various aromatic aldehydes.
Amal Rabahi, Mustapha Mounir Bouhenna, Hasnia Abdeldjebar, Massinissa Baymout, Malika Makhloufi‐Chebli, Walter Luyten, Hamdi Bendif, Anis Ahmad Chaudhary, Walid Elfalleh, Stefania Garzoli   +9 more
wiley   +1 more source

Cutibacterium Adaptation to Life on Humans Provides a Potential C acnes Infection Biomarker. [PDF]

J Invest Dermatol
Shafiuddin M, Huang WC, Prather GW, Anton JR, Martin AL, Sillart SB, Tang JZ, Vittori MR, Prinsen MJ, Ninneman JJ, Manithody C, Henderson JP, Aleem AW, Ilagan MXG, McCoy WH.   +14 more
europepmc   +1 more source

A pressure-jump EPR system to monitor millisecond conformational exchange rates of spin-labeled proteins. [PDF]

Protein Sci
Grosskopf JD, Sidabras JW, Altenbach C, Anderson JR, Mett RR, Strangeway RA, Hyde JS, Hubbell WL, Lerch MT.   +8 more
europepmc   +1 more source

Covalent drug rescue of multiple p53 mutants by stabilizing vinyl sulfone fragments hints to a specific refolding mechanism for R282W

Protein Science, Volume 35, Issue 6, June 2026.
Abstract The tumor suppressor protein p53 plays a crucial role in cell cycle regulation. In approximately 50% of all tumors, mutations in p53 are observed. Although the top hot spot mutations impair DNA binding, other mutations affect the thermal stability of the protein, leading to its rapid denaturation in physiological conditions.
Jason Stahlecker, Theresa Klett, Robert Spiegel, Martin Schwer, Finn Mier, Sven Aldea, Benedikt Masberg, Michael Lämmerhofer, Thilo Stehle, Frank M. Böckler   +9 more
wiley   +1 more source

Targeting BARD1 suppresses a Myc-dependent transcriptional program and tumor growth in pancreatic ductal adenocarcinoma. [PDF]

Neoplasia
Patel S, Jenkins E, Kusurkar RP, Lee S, Jiang W, Nevler A, McCoy M, Pishvaian MJ, Sears RC, Brody JR, Yeo CJ, Jain A.   +11 more
europepmc   +1 more source

Large Language Models for Explainable Medical Text Summarization: A Systematic Literature Review

WIREs Data Mining and Knowledge Discovery, Volume 16, Issue 2, June 2026.
The graphical abstract highlights the three key aspects addressed in this review: the technical background of medical text summarization methods relevant to clinical decision support; the LLM background in providing context for its diagnosis and clinical significance; and clinical decision support with summarization and explainability in patient care ...
Aleka Melese Ayalew, Md Rabiul Hasan, Tapio Seppänen, Mourad Oussalah   +3 more
wiley   +1 more source