Results 111 to 120 of about 188,053 (286)

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

Wild meat consumption in changing rural landscapes of Indonesian Borneo

People and Nature, EarlyView.
Abstract Wild meat can play a crucial role in the food system of rural communities residing near tropical forests. Yet, socio‐ecological changes across tropical landscapes are impacting the patterns and sustainability of meat consumption. To understand the prevalence, frequency and drivers of wild meat, domestic meat and fish consumption in this ...
Katie L. Spencer, Daniel J. Ingram, Namrata B. Anirudh, Ardiantiono, Susan M. Cheyne, Leejiah J. Dorward, Abdul Kadir, Michaela G. Y. Lo, Courtney L. Morgans, Jatna Supriatna, Nurul L. Winarni, Freya A. V. St. John, Matthew J. Struebig   +12 more
wiley   +1 more source

Genomic structure and ex situ conservation of the North American grapevine Vitis labrusca

PLANTS, PEOPLE, PLANET, EarlyView.
The North American wild grapevine species Vitis labrusca is an important source of disease resistance and climate resilience traits for breeding new grapevine cultivars. To ensure its continued use in breeding, V. labrusca must be accurately identified and genetically diverse material must be conserved.
Zoë Migicovsky, Clay Elzinga, Mia C. Lauzon, Thomas Connor, Kylie DeViller, Claire Dinn, Grace M. Earle, Emma Hockley, Olivia Lennon, Lillian A. Ricker, Peter M. Roberts, Katrina M. Robinson, Aditi Sharma, Paris N. Spencer, Sammy Stockdale, Liam L. Tingley, Annelies Yates, Jason P. Londo, Peter Cousins   +18 more
wiley   +1 more source

EBV-Positive Pleomorphic Variant Transformation of CD5-Negative Mantle Cell Lymphoma: A Rare Case Report and Literature Review

Case Reports in Hematology
Mantle cell lymphoma (MCL) is a mature B-cell lymphoma associated with cyclin D family rearrangements and typically expresses CD5 and cyclin D1. Epstein–Barr virus- (EBV-) positive MCL is rare, and the role of EBV infection and its transformation in MCL ...
Amy Song, Julie Y. Li, Samuel G. Cockey, Richard Shao, Hailing Zhang   +4 more
doaj   +1 more source

Survey on AI‐Enabled Computer Vision Technologies and Applications for Space Robotic Missions

Journal of Field Robotics, EarlyView.
ABSTRACT This survey provides a comprehensive overview of recent advancements and challenges in Artificial Intelligence (AI)‐enabled computer vision (CV) techniques for space robotic missions, spanning critical phases such as Entry, Descent, and Landing (EDL), orbital operations, and planetary surface exploration.
Maciej Quoos, Steven Kay, Julia Wajoras, Robert Field, Evridiki V. Ntagiou, Fakher Mohammad, Yang Gao   +6 more
wiley   +1 more source

Influence of Temperature on the Reliability of Graphene‐Based Ozone Sensors

Small, EarlyView.
The reliability and stability of inkjet‐printed graphene flake sensors are evaluated. Stress assessments take place in ozone‐rich environments and at elevated temperatures, with the observation of a change in resistance. Surface‐sensitive techniques serve to investigate the failure and degradation mechanisms of printed graphene.
Archa Jain, Kathrin Ganzhorn, Aleksandr Baklanov, Tim Schaffus, Werner Breuer, Jasper Ruhkopf, Janio Venturini, Sebastian Troll, Annalisa Cappellani, Max C. Lemme   +9 more
wiley   +1 more source

Iowa Population Exposures to Metals and Metalloids in Well Water

Environmental Toxicology, EarlyView.
ABSTRACT Previous Iowa studies suggest low levels and chronic arsenic exposures are associated with prostate cancer. The rural Iowa population heavily relies on private wells for drinking water resources and thus is vulnerable to contaminants such as heavy metals found in well water.
Donald L. Simmons, Brian Wels, Alyssa Mattson, Elizabeth M. Miller, Zachary E. Hoggarth, Maya Sternberg, Susie Y. Dai, Dustin May, Michael Schueller, Michael Pentella   +9 more
wiley   +1 more source

Diving Deeper Into Mechanisms of Acrylamide‐Induced Toxicity: RNA Sequencing Reveals Transcriptomic Alteration and Retrotransposon Expression in Drosophila melanogaster

Environmental Toxicology, EarlyView.
ABSTRACT Given the inevitability of human and animal exposure to acrylamide, there is increasing concern regarding its potential health risks. While a number of molecular mechanisms have been proposed, the complexity of acrylamide toxicological pathways and interactions remains incompletely characterized.
Oluwabukola Mary Farodoye, Titilayomi Ayomide Otenaike, Daniela Moreira Mombach, Monica Medeiros Silva, Amos Olalekan Abolaji, Elgion Lucio Da Silva Loreto   +5 more
wiley   +1 more source

Cognitive Economy: The Economic Dimension of the Theory of Knowledge by Nicholas Rescher (University of Pittsburgh Press, Pittsburgh, 1989), pp. x +168, $US29.95, ISBN 0-8229-3617-8

Prometheus, 1991
D. McL. Lamberton
doaj   +1 more source

Does Sickle Cell Anaemia Have a Relationship With Avascular Pulp Necrosis? A Systematic Review

Australian Endodontic Journal, EarlyView.
ABSTRACT This systematic review examined the relationship between sickle cell disease (SCD), an inherited genetic hemoglobinopathy, and avascular pulp necrosis (APN) in intact teeth. A comprehensive search of eight electronic databases was performed up to December 2024.
Elidiane Elias Ribeiro, Karin Sá Fernandes, Erika Sales Joviano Pereira, Angelica Maria Cupertino Lopes Marinho, Jefferson R. Tenório, Márcia Pereira Alves dos Santos   +5 more
wiley   +1 more source