Results 211 to 220 of about 66,016 (261)
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Proceedings of the XIV Brazilian Symposium on Information Systems, 2018
Software measures are underused due to the difficulty of interpreting their results and associating them to software quality. Different environments, languages, and development methodologies require specific measures and range of values. Thus, this paper proposes MCL (Metrics-based Constraint Language), a language that allows to specify, for different ...
Christian Marlon Souza Couto +3 more
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Software measures are underused due to the difficulty of interpreting their results and associating them to software quality. Different environments, languages, and development methodologies require specific measures and range of values. Thus, this paper proposes MCL (Metrics-based Constraint Language), a language that allows to specify, for different ...
Christian Marlon Souza Couto +3 more
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Puma*Mcl-1 interaction is not sufficient to prevent rapid degradation of Mcl-1 [PDF]
Oncogene, 2005 Although Puma (p53 upregulated modulator of apoptosis) was known as a principal mediator of cell death in response to diverse apoptotic signals, the molecular mechanism underlying its proapoptotic regulation remains largely uncharacterized. Here we reported that myeloid cell leukemia-1 (Mcl-1), an anti-apoptotic member of the Bcl-2 family with a rapid ...
Yide Mei, Wenjing Du, Mian Wu
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Implementation of MCL for effective ICT
6th Joint IFIP Wireless and Mobile Networking Conference (WMNC), 2013In this contemporary world, many new digital technologies are introduced every day. Every field in this world is influenced by these technologies which changes the traditional way of functioning. Education field is also forced to undergo the modernization and digitization.
R. D. Balaji +3 more
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Blood, 2010
In this issue of Blood , Hartmann and colleagues report on the results of a high-resolution genomic profiling study in a large series of MCL. Copy number alteration and expression data are amalgamated with clinical outcome. Their data confirm the critical role of the cell-cycle and DNA damage-
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In this issue of Blood , Hartmann and colleagues report on the results of a high-resolution genomic profiling study in a large series of MCL. Copy number alteration and expression data are amalgamated with clinical outcome. Their data confirm the critical role of the cell-cycle and DNA damage-
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Blood, 2012
One of the major challenges in the evaluation of new therapies for lymphoma and other hematologic malignancies has been the ability to demonstrate changes in important biomarkers and pharmacodynamic end points in the tumor cell population.In this issue of Blood, Leonard et al provide an elegant evaluation of the cyclin-dependent kinase (cdk) inhibitor ...
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One of the major challenges in the evaluation of new therapies for lymphoma and other hematologic malignancies has been the ability to demonstrate changes in important biomarkers and pharmacodynamic end points in the tumor cell population.In this issue of Blood, Leonard et al provide an elegant evaluation of the cyclin-dependent kinase (cdk) inhibitor ...
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Blood, 2008
Although Mcl-1 has been established as a survival and maintenance protein during in vitro incubations of primary CLL cells, in this issue of Blood, Pepper and colleagues further demonstrate the association of Mcl-1 with other prognostic factors and the role of this antiapoptotic protein in disease progression and outcome for patients with CLL.
Varsha, Gandhi +2 more
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Although Mcl-1 has been established as a survival and maintenance protein during in vitro incubations of primary CLL cells, in this issue of Blood, Pepper and colleagues further demonstrate the association of Mcl-1 with other prognostic factors and the role of this antiapoptotic protein in disease progression and outcome for patients with CLL.
Varsha, Gandhi +2 more
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Treatment of MCL Injury in Combined ACL/MCL Injury
2017Combined ACL and MCL injuries are the most common combined ligament injuries of the knee. Traditional management of isolated MCL injuries has been conservative. However, grade III MCL injuries or those associated with the PMC can lead to rotational laxity that can significantly impact patient functionality.
Daniel Whelan +4 more
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Journal of Knee Surgery, 2010
Cigarette smoking has been shown to delay soft tissue healing and complicate musculoskeletal recovery. Its deleterious effects have been proven in bone and soft tissue, although to a much more limited fashion in ligament or tendon. We exposed 120 experimental mice to two cigarettes per day for 2 months and then induced a blunt medial collateral ...
Rick, Wright +3 more
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Cigarette smoking has been shown to delay soft tissue healing and complicate musculoskeletal recovery. Its deleterious effects have been proven in bone and soft tissue, although to a much more limited fashion in ligament or tendon. We exposed 120 experimental mice to two cigarettes per day for 2 months and then induced a blunt medial collateral ...
Rick, Wright +3 more
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Treatment of relapsed/refractory MCL
BloodAbstract Mantle cell lymphoma (MCL) is a rare subtype of B-cell non-Hodgkin lymphoma that is clinically characterized by its heterogeneous behavior, with courses ranging from indolent to highly aggressive cases with limited prognosis.
Elisabeth Silkenstedt, Martin Dreyling
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Cell Death & Differentiation, 2006
Department of Biochemistry, St. Jude Children’s Research Hospital, Memphis,TN 38105, USA* Corresponding author: JT Opferman, Department of Biochemistry, St. JudeChildren’s Research Hospital, 332 N. Lauderdale, Memphis, TN 38105, USA.Tel: þ1-901-495-5524; Fax: þ1-901-525-8025;E-mail: joseph.opferman@stjude ...
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Department of Biochemistry, St. Jude Children’s Research Hospital, Memphis,TN 38105, USA* Corresponding author: JT Opferman, Department of Biochemistry, St. JudeChildren’s Research Hospital, 332 N. Lauderdale, Memphis, TN 38105, USA.Tel: þ1-901-495-5524; Fax: þ1-901-525-8025;E-mail: joseph.opferman@stjude ...
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