Results 111 to 120 of about 163,614 (287)

Cooperativity Beyond Caging: Generalized Mode Coupling Theory

, 2006
The validity of mode coupling theory (MCT) is restricted by an uncontrolled factorization approximation of density correlations. The factorization can be delayed and ultimately avoided, however, by explicitly including higher order correlations.
David R. Reichman, I. S. Gradshteyn, Kunimasa Miyazaki, Peter Mayer, U. Balucani, W. Götze   +5 more
core   +1 more source

From Natural Discovery to AI‐Guided Design: A Curated Collection of Compact Enhancers for Crop Engineering

Advanced Science, EarlyView.
ABSTRACT Precise transgene‐free gene upregulation remains a challenge in crop biotechnology, as conventional enhancers often exceed CRISPR‐mediated knock‐in size constraints and face regulatory hurdles. Here we establish a foundational cross‐species resource of compact transcriptional enhancers developed via STEM‐seq, a high‐throughput screening ...
Qi Yao, Jin Gao, Keling Wang, Yufeng Liu, Peijin Han, Hong Pan, Xiaofeng Yang, Qianlan Yin, Dating Zhong, Lu Ye, Qi Deng, Lingling Gao, Xiaoyu Tu, Dequan Wang, Yuming Lu   +14 more
wiley   +1 more source

On the Bauschinger effect in supercoooled melts under shear: results from mode coupling theory and molecular dynamics simulations

, 2012
We study the nonlinear rheology of a glass-forming binary mixture under the reversal of shear flow using molecular dynamics simulations and a schematic model of the mode-coupling theory of the glass transition (MCT).
Bhattacharjee, Amit Kumar, Frahsa, Fabian, Fuchs, Matthias, Horbach, Jürgen, Voigtmann, Thomas   +4 more
core   +1 more source

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

Advanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu, Ting He, Yu Qian, Jia Li, Bowei Ni, Xiaojie Xu, Huanbo Wang, Peng Wang, Guoqing Cao, Siqi Ying, Guangyu Ding, Rong Wang, Zenghui Gu, Wei Li, Zhentao Man, Houfeng Zheng, Zhaohua Zhu, Zhen Li, Qingjun Meng, Chao Zheng, Liu Yang   +20 more
wiley   +1 more source

Gamma radiation exposure of MCT diode arrays

, 2006
Investigations of electrical properties of long-wavelength infrared (LWIR) mercury cadmium telluride (MCT) arrays exposed to gamma-radiation have been performed.
F F Sizov, Gumenyuk-Sichevskaya J V, I O Lysiuk, J V Gumenjuk-Sichevska, Robinson H G, Rogalski A, S G Bunchuk, Sizov F F, Sizov F F, V V Zabudsky, Voitsekhovsky A V   +10 more
core   +1 more source

Universal Solvent Escape Strategies for Efficient Curing of Hydrogen‐Bond‐Rich 3D Printing Inks

Advanced Science, EarlyView.
This study developed a new 3D printing method for hydrogen‐bonded polymers by combining solvent replacement, nanoparticles, and optimized printing paths. This allows fast, precise scaffold fabrication. The scaffolds can be easily customized and release therapeutic agents slowly through protonation, enabling personalized bone, blood vessel, and nerve ...
Jie Chen, Qing Zhao, Wentao Fu, Weixian Chen, Xiaoqian Zhang, Gaiying Ye, Qinglei Meng, Liyuan Shao, Qian Ma, Lin Zhao, Ying Zhao, Weihua Guo   +11 more
wiley   +1 more source

Synthesis and QSAR Studies of Claramine Derivatives, a New Class of Broad-Spectrum Antimicrobial Agents

Molecules
The development of new antibiotics has been recognized for over two decades as a major challenge in combating multidrug-resistant bacteria. Herein, we report the synthesis and QSAR studies of claramine derivatives, a new class of broad-spectrum ...
Marine Blanchet, Carole Di Giorgio, Jean Michel Brunel   +2 more
doaj   +1 more source

Hepatocyte BPGM Induces RET Lactylation and Macrophage Reprogramming to Promote Tumorigenesis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Mechanistic schematic diagram.BPGM promotes the expression level of RET by increasing the lactylation of RET‐K549 and inhibiting its ubiquitination levels in HCC cells. Furthermore, BPGM in HCC cells could also promote M2 polarization in macrophages through lactate secretion. Both of the mechanisms could promote the progression of HCC. ABSTRACT Aerobic
Jiajia Zhang, Lu Shi, Liangliang Lin, Yang Zhang, Miao Zhang, Lili Wu, Yong Xia, Yaqiong Zhang, Peng Han, Likun Zhuang, Liang Shi   +10 more
wiley   +1 more source

Rib‐Reinforced Ultralight and Ultra‐Strong Shell Lattices

Advanced Science, EarlyView.
This study thoroughly reveals the relation between the curvature and stress direction of triply periodic minimal surface (TPMS) thin shell lattices and proposes a novel rib reinforcement design strategy to incorporate ribs along the line of asymptotes (LOA) and the line of principal curvatures (LOC) to enhance the strength of ultralight TPMS shell ...
Winston Wai Shing Ma, Lei Zhang, Junhao Ding, Shuo Qu, Michael Yu Wang, Xu Song, Ming Wang Fu   +6 more
wiley   +1 more source

Advances in methods and concepts provide new insight into antibiotic fluxes across the bacterial membrane

Communications Biology
The sophisticated envelope of Gram-negative bacteria modulates the uptake of small molecules in a side-chain-sensitive manner. Despite intensive theoretical and experimental investigations, a general set of pathways underpinning antibiotic uptake has not
Julia Vergalli, Matthieu Réfrégiers, Paolo Ruggerone, Mathias Winterhalter, Jean-Marie Pagès   +4 more
doaj   +1 more source