Results 81 to 90 of about 163,984 (309)
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Advanced Science, EarlyView.The study identifies a NIPAL1‐driven metabolic‐epigenetic circuit in esophageal squamous cell carcinoma that promotes glycolysis, lactate accumulation, and H3K18 histone lactylation, forming a self‐sustaining loop that suppresses CD8+ T cell immunity.
Ri‐Xin Chen +15 more
wiley +1 more source
Plasma diagnostic experiments on board of the Brazilian scientific microsatellite SACI-1
Geofísica Internacional, 2000 Se proponen tres experimentos de diagnósticos de plasma conocidos como PLASMEX para investigar el fenómeno de las burbujas de plasma ionosféricas que se sabe existen en la región ionosférica en un amplio rango de latitudes. Se intentarán hacer mediciones
P. Muralikrishna +3 more
doaj +1 more source
Temperature dependence of the Power law exponent of relaxation in a supercooled Liquid
, 2001 The dynamics of Lennard-Jones fluid is studied through extended mode coupling theory (MCT) with the inclusion of the slow mode of defect density. Inclusion of defect density facilitates the liquid like state for temperatures much lower than predicted ...
Das, Shankar P., Srivastava, Sudha
core +2 more sources
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
The shadows cast by buildings and towers in cities and by montains in the countryside
Revista Brasileira de Ensino de FísicaOften astronomers of the Observatório Nacional are asked about how the shadow cast from a building or a tower to be built will impact crowded areas; in which way they would interfere with the wellfare by depriving population from sunlight.
João Luiz Kohl Moreira
doaj +1 more source
Tijdschrift voor GeneeskundeThe number of elderly in our society is increasing. Psychiatric problems are common in this population. For adults aged 18 to 65, there already is psychiatric crisis home treatment for patients experiencing a psychiatric crisis at home. However, this did not yet exist in Belgium for adults over the age of 65. Since the 1st of November 2021, people over
Stoop, Simon +2 more
openaire +2 more sources
Dynamics of simulated water under pressure
, 1999 We present molecular dynamics simulations of the SPC/E model of water to probe the dynamic properties at temperatures from 350 K down to 190 K and pressures from 2.5GPa (25kbar) down to -300MPa (-3kbar).
Sciortino, Francesco +2 more
core +1 more source
Advanced Science, EarlyView.A bifunctional lactate oxidase‐like and catalase‐like artificial enzyme (Metazyme) is integrated into a rod‐shaped microgel (MetaRgel) to enable cascade lactate oxidation and oxygen regeneration. By reprogramming the wound metabolic microenvironment, MetaRgel alleviates excessive lactate accumulation, oxidative stress, hypoxia, and inflammation ...
Yongyuan Kang +9 more
wiley +1 more source
Characterization and snubbing of a bidirectional MCT in a resonant ac link converter [PDF]
The MOS-Controlled Thyristor (MCT) is emerging as a powerful switch that combines the better characteristics of existing power devices. A study of switching stresses on an MCT switch under zero voltage resonant switching is presented.
Elbuluk, Malik E. +2 more
core +1 more source