Results 151 to 160 of about 3,368,671 (295)

Chapter 05: Practicing Pathology at MD Anderson

open access: yes, 2012
In this chapter, Dr. Bruner traces how she became a faculty associate at MD Anderson in 1984 (becoming an assistant professor in 1985). She had already become familiar with MD Anderson\u27s electron microscopy service while at Baylor, working closely ...
Bruner, Janet M., MD   +1 more
core  

Threonine 348 regulates the subcellular localization of PTEN

open access: yesFEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

Chapter 1: MD Anderson Culture; and Faculty

open access: yes, 2014
Dr. Kleinerman begins this chapter by explaining that she came to MD Anderson from the NCI in the early eighties because she was interested in running clinical trials with children diagnosed with osteosarcoma and was unable to do so at the NCI.
Kleinerman, Eugenie S., MD   +1 more
core  

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

open access: yesFEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn   +2 more
wiley   +1 more source

Chapter 09: Defining the Mission that Shapes MD Anderson Growth

open access: yes, 2012
Dr. Mendelsohn explains how the unprecedented growth accomplished during his presidency was not growth for growth’s sake, but guided by the MD Anderson mission. First he explains the three factors enabling growth in the mid and late nineties. First the
Mendelsohn, John, MD   +1 more
core  

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

open access: yesFEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao   +10 more
wiley   +1 more source

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