Results 31 to 40 of about 3,784,520 (317)

Harvesting graphics power for MD simulations [PDF]

Molecular Simulation, 2008
12 pages, 5 figures.
van Meel, J.A., Arnold, A., Frenkel, D., Portegies Zwart, S.F., Belleman, R.G.   +4 more
openaire   +5 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Michael Keating, MD, Oral History Interview, May 20, 2014 [PDF]

, 2014
Major topics covered: The history of translational research at MD Anderson The Department of Developmental Therapeutics MD Anderson culture Changes at MD Anderson with growth The Moon Shots Program Leadership at MD Anderson Global Research ...
Keating, Michael, MD, Rosolowski, Tacey A., PhD   +1 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Structural exploration of the PfBLM Helicase-ATP Binding Domain and implications in the quest for antimalarial therapies

Journal of Vector Borne Diseases
Background & objectives: The battle against malaria has witnessed remarkable progress in recent years, characterized by increased funding, development of life-saving tools, and a significant reduction in disease prevalence.
Hattan S Gattan, Bassam M Al-ahmadi, Abdullah F Shater, Nizar H Saeedi, Mohammed H Alruhaili   +4 more
doaj   +1 more source

StandsSIM-MD: a Management Driven forest SIMulator

Forest Systems, 2016
Aim of the study: The existing stand level forest simulators available in Portugal were not developed with the aim of including up-to-date model versions and were limited in terms of accounting for forest management. The simulators’ platform, sIMfLOR was recently created to implement different growth models with a common philosophy.
Susana Barreiro, João Rua, Margarida Tomé   +2 more
openaire   +6 more sources

Alma Rodriguez, MD, Video Oral History Interview, April 17, 2017 [PDF]

, 2019
Major Topics Covered: The history of multidisciplinary care at MD Anderson MD Anderson algorithms of care MD Anderson culturehttps://openworks.mdanderson.org/mchv_interviewsessions/1046/thumbnail ...
Rodriguez, Alma, MD, Rosolowski, Tacey A., PhD   +1 more
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Robert Byers, MD, Oral History Interview, The First 50 Years of Surgery at MD Anderson (1945 – 1995), October 14, 2019 [PDF]

, 2019
Major Topics Covered: Recruitment to MD Anderson Evolution of the Head & Neck Surgery Department Portraits of key figures in surgery at MD Andersonhttps://openworks.mdanderson.org/surgeryhist_interviewsessions/1004/thumbnail ...
Balch, Charles M., MD, Byers, Robert, MD, Rosolowski, Tacey A., PhD   +2 more
core  

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source